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Isoforms diversity and transcriptional regulation of floral meristem identity and pathway integrators, driving floral transition in mango under subtropics
Floral initiation in mango is intricately regulated by a complex genetic network that integrates diverse environmental and endogenous cues. The flowering patterns in different varieties contingent upon their genetic network and sensitivity to the environmental signals, culminating in the phenomenon of "alternate bearing in several mango varieties. In this study, we conducted a comprehensive molecu
Ibrutinib combined with immunochemotherapy with or without autologous stem-cell transplantation versus immunochemotherapy and autologous stem-cell transplantation in previously untreated patients with mantle cell lymphoma (TRIANGLE) : a three-arm, randomised, open-label, phase 3 superiority trial of the European Mantle Cell Lymphoma Network
Background: Adding ibrutinib to standard immunochemotherapy might improve outcomes and challenge autologous stem-cell transplantation (ASCT) in younger (aged 65 years or younger) mantle cell lymphoma patients. This trial aimed to investigate whether the addition of ibrutinib results in a superior clinical outcome compared with the pre-trial immunochemotherapy standard with ASCT or an ibrutinib-con
Magnon-mediated topological superconductivity in a quantum wire
Many emergent phases of matter stem from the intertwined dynamics of quasiparticles. Here we show that a topological superconducting phase emerges as the result of interactions between electrons and magnons in a quantum wire and a helical magnet. The magnon-mediated interaction favors triplet superconductivity over a large magnetic phase space region, and stabilizes topological superconductivity o
Aging-dependent mitochondrial bioenergetic impairment in the skeletal muscle of NNT-deficient mice
Overall health relies on features of skeletal muscle that generally decline with age, partly due to mechanisms associated with mitochondrial redox imbalance and bioenergetic dysfunction. Previously, aged mice genetically devoid of the mitochondrial NAD(P)+ transhydrogenase (NNT, encoded by the nicotinamide nucleotide transhydrogenase gene), an enzyme involved in mitochondrial NADPH supply, were sh
Single German centre experience with patient journey and care-relevant needs in amyloidosis : The German AMY-NEEDS research and care program
Background Amyloidosis is a rare multi-system disorder associated with frequently delayed diagnosis, enormous disease burden and psychosocial distress. Methods Systematic assessment of needs was performed by a subtype-spanning questionnairebased survey within the AMY-NEEDS research and care program. Results 118 patients with proven amyloidosis (62.7% ATTR, 22.0% AL, 15.3% other forms) were include
How do labour market conditions explain the development of mental health over the life-course? a conceptual integration of the ecological model with life-course epidemiology in an integrative review of results from the Northern Swedish Cohort
Background: The aim of this study was to contribute to the theoretical development within the field of labour market effects on mental health during life by integrating Bronfenbrenner’s ecological model with mainly earlier theoretical work on life-course theory. Methods: An integrative review was performed of all 52 publications about labour market conditions in relation to mental health from the
Zero-Shot Segmentation of Eye Features Using the Segment Anything Model (SAM)
The advent of foundation models signals a new era in artificial intelligence. The Segment Anything Model (SAM) is the first foundation model for image segmentation. In this study, we evaluate SAM's ability to segment features from eye images recorded in virtual reality setups. The increasing requirement for annotated eye-image datasets presents a significant opportunity for SAM to redefine the lan
Identified charged-hadron production in p+Al, He 3 +Au, and Cu+Au collisions at sNN =200 GeV and in U+ U collisions at sNN =193 GeV
The PHENIX experiment has performed a systematic study of identified charged-hadron (π±, K±, p, p¯) production at midrapidity in p+Al, He3+Au, and Cu+Au collisions at sNN=200GeV and U+U collisions at sNN=193GeV. Identified charged-hadron invariant transverse-momentum (pT) and transverse-mass (mT) spectra are presented and interpreted in terms of radially expanding thermalized systems. The particle
Digitalization and Retirement Contribution Behavior: Evidence from Administrative Data
Retirement savings decisions are increasingly mediated by digital technologies that promise to help individuals plan adequately for their retirement. We exploit a natural experiment to show that introducing a digital pension application increases the probability of making a voluntary retirement contribution by 1.8 percentage points, from an average pretreatment contribution rate of 2.8%. Men and h
Towards a resilient and resource-efficient local food system based on industrial symbiosis in Härnösand : a Swedish case study
The endeavour to align the goals of the Swedish food strategy with the national environmental quality objectives and the 17 global SDGs, presents an extraordinary challenge that calls for systemic innovation. Industrial symbiosis can potentially provide the means for increasing sustainable food production, using locally sub-exploited resources that can reduce the need for land, agrochemicals, tran
Neonatal healthcare professionals’ experiences of intact cord resuscitation in the mother´s bed- an interview study
Background: Intact cord resuscitation in the first three minutes of life improves oxygenation and Apgar scores. The practise of intact cord resuscitation implies the umbilical cord still being connected to the placenta for at least one minute while providing temperature control and equipment for resuscitation. Healthcare professionals described practical challenges in providing intact cord resusci
Estimating major merger rates and spin parameters ab initio via the clustering of critical events
We build a model to predict from first principles the properties of major mergers. We predict these from the coalescence of peaks and saddle points in the vicinity of a given larger peak, as one increases the smoothing scale in the initial linear density field as a proxy for cosmic time. To refine our results, we also ensure, using a suite of ∼400 power-law Gaussian random fields smoothed at ∼30 d
Dynamic anthropomorphic thorax phantom for quality assurance of motion management in radiotherapy
Background and purpose: Motion management techniques are important to spare the healthy tissue adequately. However, they are complex and need dedicated quality assurance. The aim of this study was to create a dynamic phantom designed for quality assurance and to replicate a patient's size, anatomy, and tissue density. Materials and methods: A computed tomography (CT) scan of a cancer patient was u
Input precision, output excellence : the importance of data quality control and method selection in disease risk mapping —authors’ reply
Periprosthetic Joint Infection After Total Knee Arthroplasty With or Without Antibiotic Bone Cement
Importance: Despite increased use of antibiotic-loaded bone cement (ALBC) in joint arthroplasty over recent decades, current evidence for prophylactic use of ALBC to reduce risk of periprosthetic joint infection (PJI) is insufficient. Objective: To compare the rate of revision attributed to PJI following primary total knee arthroplasty (TKA) using ALBC vs plain bone cement. Design, Setting, and Pa
Practical Guidance on Establishing a Molecular Testing Pathway for Alterations in Homologous Recombination Repair Genes in Clinical Practice for Patients with Metastatic Prostate Cancer
CONTEXT: Prostate cancer is a molecularly heterogeneous disease that is amenable to diagnostic testing to identify patients potentially eligible for personalised treatments inform familial risk and provide relevant information about potential prognosis. Several guidelines support the integration of genomic testing in a shared decision-making framework so that both health care professionals (HCPs)
How Little is Enough? : Sustainable Methods of Performance for Transformative Encounters
At the core of this artistic doctoral thesis are four performance projects designed to counter the consumer-driven nature of contemporary performance-making while also addressing the need to develop sustainable methods of performance. Guided by the question: how to construct sustainable methods of performance for transformative encounters? the inquiry transcends the different layers of performance
How Little is Enough? : Testimony of a Pilgrim
This book is a key component of a PhD thesis derived from the artistic researchproject; How Little is Enough? and contains the essay Testimony of a Pilgrim andmanuscripts from the four performances that are central to the research project. Theentire PhD thesis is mediated through an on-line exposition on Research Catalogueusing mixed formats. The exposition encompasses the complete researchoutput
Bactogram : Spatial Analysis of Bacterial Colonization in Epidermal Wounds
Skin barrier damage and subsequent development of harmful microbiota contribute to conditions such as wound infections, atopic dermatitis, and chronic wounds, which impact millions of people globally and pose a significant economic burden on healthcare systems. Established microbial sampling methods, such as swabs and tissue biopsies, provide limited information on the spatial distribution of bact