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Patient-Reported Outcomes (PROs) and PRO Remission Rates in 12,262 Biologic-Naïve Patients With Psoriatic Arthritis Treated With Tumor Necrosis Factor Inhibitors in Routine Care

Objective. To evaluate patient-reported outcomes (PROs) after initiation of tumor necrosis factor inhibitor (TNFi) treatment in European real-world patients with psoriatic arthritis (PsA). Further, to investigate PRO remission rates across treatment courses, registries, disease duration, sex, and age at disease onset. Methods. Visual analog scale or numerical rating scale scores for pain, fatigue,

Toward Accessible Biophotonics : Instrumentation for Insect and Vegetation Applications

Människors nyfikenhet och drivkraft att förstå och mäta vår värld har lett till många vetenskapliga framsteg. Vårt ständiga sökande efter kunskap har hjälpt oss att bland annat förhindra sjukdomar, förbättra skördar och förstå de ekosystem vi lever i. Dock varierar förutsättningar och utmaningar för forskning runt om i världen, och i många forskningsmiljöer saknas det tillgång till avancerad labor

Anticoagulation after liver transplantation: a retrospective audit and case-control study

Anticoagulation may in the future become a therapeutic option for the prevention of liver fibrosis, such as due to recurrent hepatitis C virus infection after liver transplantation. Currently, there are other indications for anticoagulation after liver transplantation but no data regarding its safety. The objective of the study was to audit the safety of anticoagulation after liver transplantation

Novel indices reveal that pollinator exposure to pesticides varies across biological compartments and crop surroundings

Declines in insect pollinators have been linked to a range of causative factors such as disease, loss of habitats, the quality and availability of food, and exposure to pesticides. Here, we analysed an extensive dataset generated from pesticide screening of foraging insects, pollen-nectar stores/beebread, pollen and ingested nectar across three species of bees collected at 128 European sites set i

Disease burden and unmet need for acute allergic reactions – A patient perspective

Background: Acute allergic reactions (AARs) occur shortly after exposure to an allergen, and the severity is on a continuum. Systemic corticosteroids (CS) are mainstay treatment of moderate to severe AARs, whereas those at risk of the most severe AARs (ie, anaphylaxis) are also recommended prescription of epinephrine autoinjectors. There is limited research on the impact of AARs not fulfilling the

Longitudinal ECG changes in tetralogy of Fallot and association with surgical repair

Background: ECG abnormalities have been linked to adverse changes in right ventricular (RV) morphology and poor clinical outcomes in repaired Tetralogy of Fallot (rTOF). Our aim was to describe how ECG changes progress in early and intermediate follow-up and whether types of surgical strategy at the time of primary repair affected these changes. Methods: We studied patients with rTOF born 2000–201

Pituitary Gonadotrophic Hormone Synthesis, Secretion, Subunit Gene Expression and Cell Structure in Normal and Follicle-Stimulating Hormone β Knockout, Follicle-Stimulating Hormone Receptor Knockout, Luteinising Hormone Receptor Knockout, Hypogonadal and Ovariectomised Female Mice

To investigate the relationship between gonadotroph function and ultrastructure, we have compared, in parallel in female mice, the effects of several different mutations that perturb the hypothalamic-pituitary-gonadal axis. Specifically, serum and pituitary gonadotrophin concentrations, gonadotrophin gene expression, gonadotroph structure and number were measured. Follicle-stimulating hormone β kn

Industrial policy for a circular industrial transition in Sweden: An exploratory analysis

Currently, both the US and the EU are pursuing industrial policies to support climate mitigation objectives. The climate transition will require increased use of material resources, but the envisioned industrial policies do not sufficiently address resource use, despite the current unsustainable global resource-use trajectory. The lack of industrial policy in this field is therefore relevant and t

Para sport and anti-doping: a study of Swedish Para athletes' experiences and perceptions

Introduction: A well-functioning anti-doping system relies on being perceived by athletes as effective, fair, and practically feasible to implement. While research has highlighted the views of Olympic athletes on anti-doping over the past decade, the experiences and perceptions of Para athletes have not been extensively explored. The purpose of this study was to examine Swedish elite Para athletes

Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition

Background: Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is associated with the aggressiveness of several types of solid cancers. This study investigated COMP's role in ovarian cancer, exploring clinicopathological links and mechanistic insights.Methods: To study the association of COMP exp

Facilitating clinically relevant skin tumor diagnostics with spectroscopy-driven machine learning

In the dawning era of artificial intelligence (AI), health care stands to undergo a significant transformation with the increasing digitalization of patient data. Digital imaging, in particular, will serve as an important platform for AI to aid decision making and diagnostics. A growing number of studies demonstrate the potential of automatic pre-surgical skin tumor delineation, which could have t

Brottsoffers yttrandefrihet och förtalsbrottet

Den här artikeln handlar om hur förtalsbrottet tillämpas på situa­tioner då en person berättar i sociala medier att hen har utsatts för våld eller sexuella övergrepp av en viss person. Inledningsvis diskuteras hur rättighets­skyddet enligt regeringsformen och Europakonventionen inverkar på tillämp­ningen av förtalsbrottet och de omständigheter som bör beaktas i avväg­ningen mellan rätten till resp

No evidence, no problem? A critical interpretive synthesis of the vulnerabilities to and experiences of sexual violence among young migrants in Europe : No evidence, no problem?

Background: Growing evidence indicates that young migrants are particularly vulnerable to sexual violence, however most research has focused on instances of sexual violence occurring in conflict zones and during transit. Much less attention has been given to the vulnerabilities to and experiences of sexual violence among young migrants in Europe.Objectives: To understand the scientific evidence re

Vocabulary development in the early school years. Association with demographic factors, formal schooling and summer vacation, and the effects of a teacher Continuing Professional Development program.

Background: Well-developed vocabulary skills are crucial for academic success. Students having the language of instruction as a second language and students from lower socioeconomic backgrounds often have lower performance on vocabulary assessments. Teachers play an important role in supporting the vocabulary development of all students, regardless of background and educational needs.Aims: To inve

Resilience through total defence : Towards a shared security culture in the Nordic–Baltic region?

This article investigates the defence policies of the Nordic and Baltic countries from the perspective of shared security culture. To that end, the article analyses conceptualisations of total defence and resilience in a comparative perspective and inquires into existing and prospective regional cooperation in this area, in order to determine to what degree there exists a common security culture b