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In clonal beta-cell lines and islets from different species, a variety of calcium channels are coupled to glucose-stimulated insulin secretion. The aim of this study was to identify the voltage-gated calcium channels that control insulin secretion in insulinoma (INS)-1 832/13 cells. The mRNA level of Ca(V)1.2 exceeded that of Ca(V)1.3 and Ca(V)2.3 two-fold. Insulin secretion, which rose tenfold in

The octahedral title complex, [PtI4(C2H6S)2] or trans PtI4(dms)2 (dms is dimethylsulfide), crystallizes in the monoclinic space group P21/n (Z=2) with molecular symmetry Ci, which is the most frequently occurring point group for trans-PtX4L2[56%, 28 structures in the Cambridge Structural Database (CSD) [Allen, 2002, Acta Cryst B58, 380-388]] followed by C1 (22%, 11 structures). The complexes form

A high intake of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been associated with reduced levels of blood pressure (BP). Their antihypertensive action may be due to the reduction of the ω-6/ω-3 ratio and the resulting competitive effect of ω-3 as compared to arachidonic acid (an ω-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators

This paper aims to provide a basis for renewed talk about "use" in computing. Four current "discourse arenas" are described. Different intentions manifest in each arena are linked to failures in "translation", different terminologies crossing disciplinary and national boundaries non-reflexively. Analysis of transnational use discourse dynamics shows much miscommunication. Conflicts like that betwe

Abstract in UndeterminedAn efficient lighting control systems (LCS) should take advantage of the natural light available, but this presents some technical challenges as well as user related issues. So far, the assessment of lighting energy consumption of LCS has been based on technical features rather than the occupants’ acceptance.This article presents the results of a monitoring study providing

Multiple myeloma is the most common indication for high-dose chemotherapy with autologous stem cell support (ASCT) in North America today. Stem cell procurement for ASCT has most commonly been performed with stem cell mobilization using colony-stimulating factors with or without prior chemotherapy. The target CD34+ cell dose to be collected as well as the number of apheresis performed varies throu

It has been suggested that intake of fatty fish may protect against both type 1 and type 2 diabetes. Hypotheses rest on the high marine omega-3 fatty acid eicosapentaenoic acid+docosahexaenoic acid (EPA+DHA) and vitamin D contents, with possible beneficial effects on immune function and glucose metabolism. Our aim was to investigate, for the first time, fatty fish consumption in relation to the ri

Purpose – The purpose of this paper is to systematically and critically review the extant literature on the design of global production and distribution networks to identify gaps in the literature and identify future research opportunities. The design aspects deal with strategic and structural decisions such as: opening or closing of manufacturing plants or distribution centres, selection of locat

The aim of this work was to study intermolecular interactions in systems containing charged polyion (polyacrylate, PA(-)), charged surfactant (C(16)TA(+)) and nonionic surfactant (C(12)E(5) or C(12)E(8)). To achieve this we have created four different phase diagrams using two different so-called complex salts, C(16)TAPA(25) and C(16)TAPA(6000), both consisting of positively charged surfactant (C(1

This article is part of the Twin Mother's Study, a study that examines influences on maternal adjustment. A number of studies have investigated the importance of genetic factors for mental health, but few of these examine how genes and the environment influence resiliency/salutogenic factors. This article investigates the relative importance of genetic and environmental influences on resiliency/sa

The fossil record is our only direct means for evaluating shifts in biodiversity through Earth's history. However, analyses of fossil marine invertebrates have demonstrated that geological megabiases profoundly influence fossil preservation and discovery, obscuring true diversity signals. Comparable studies of vertebrate palaeodiversity patterns remain in their infancy. A new species-level dataset

This paper is an attempt to solve the somewhat elusive polarity item licensing properties of wh-questions in Swedish. As has been observed by Klima (1964) for English, NPIs are gener¬ally not compatible with genuinely information seeking wh-questions, but tend to induce rhe¬torical interpretations. Distin-guishing between three types of wh-questions and the kind of information they request, I will

Analysis of in situ and satellite data shows evidence of different regional snow cover responses to the widespread warming and increasing winter precipitation that has characterized the Arctic climate for the past 40-50 years. The largest and most rapid decreases in snow water equivalent (SWE) and snow cover duration (SCD) are observed over maritime regions of the Arctic with the highest precipita

The ability of lyotropic liquid crystals to form intricate structures on a range of length scales can be utilized for the synthesis of structurally complex inorganic materials, as well as in devices for controlled drug delivery. Here we employ magnetic resonance imaging (MRI) for non-invasive characterization of nano-, micro-, and millimeter scale structures in liquid crystals. The structure is mi

In the present work, platinum and palladium nanoparticles (PtNPs and PdNPs) were decorated on the surface of multi-walled carbon nanotubes (MWCNTs) by a simple thermal decomposition method. The prepared nanohybrids, PtNPs-MWCNTs and PdNPs-MWCNTs, were cast on the surface of spectrographic graphite electrodes and then Phanerochaete chrysosporium cellobiose dehydrogenase (PcCDH) was adsorbed on the

Although COPD is a major disease worldwide there is a perplexing current uncertainty about the nature of this disease. COPI) is characterized at onset and prevalently by the involvement of the lungs and bronchi, but as the disease evolves abnormalities develop in other organs and systems and the question arises: what is the pathogenesis of these respiratory and systemic impairments? Are the altera