Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rer

Alpha isoform of smooth muscle actin (SMA) expression has been reported in giant cell tumour of bone (GCTB) and other benign and malignant bone tumours, but the pattern of SMA expression and the precise nature of SMA-expressing cells in these lesions is uncertain. We determined by immunohistochemistry the expression of SMA and other muscle and vascular markers in normal bone, GCTB and a wide range

What conformations do protein molecules populate in solution? Crystallography provides a high-resolution description of protein structure in the crystal environment, while NMR describes structure in solution but using less data. NMR structures display more variability, but is this because crystal contacts are absent or because of fewer data constraints? Here we report unexpected insight into this

The common genetic variants associated with complex traits typically lie in noncoding DNA and may alter gene regulation in a cell type-specific manner. Consequently, the choice of tissue or cell model in the dissection of disease associations is important. We carried out an expression quantitative trait loci (eQTL) study of primary human osteoblasts (HOb) derived from 95 unrelated donors of Swedis

Breast cancer is the most common form of cancer in women. While the prognosis for breast cancer patients without local or distal dissemination is relatively favorable, the prognosis is considerably worse once distal metastasis has been established. It is therefore imperative to identify molecular targets and develop novel anti-metastatic therapies that will stop, reduce or delay the spread and gro

Background: Myeloid cells have been associated with physiological and pathological angiogenesis, but their exact functions in these processes remain poorly defined. Monocyte-derived tissue macrophages of the CNS, or microglial cells, invade the mammalian retina before it becomes vascularized. Recent studies correlate the presence of microglia in the developing CNS with vascular network formation,

The article argues for a greater attention to be given to discursive approaches to the leadership of innovation through proposing a variant of Potter and Wetherell’s concept of interpretative repertoires. Drawing upon empirical material from a case study of managers engaged in R & D activities at a multimedia company, the study illustrates how the talk and thought of leadership reveals the con

Background: Postprandial lipaemia varies with gender and the composition of dietary fat due to the partitioning of fatty acids between beta-oxidation and incorporation into triacylglycerols (TAGs). Increasing evidence highlights the importance of postprandial measurements to evaluate atherogenic risk. Postprandial effects of alpha-linolenic acid (ALA) in women are poorly characterized. We therefor

Very few principles have been unraveled that explain the relationship between soil properties and soil biota across large spatial scales and different land-use types. Here, we seek these general relationships using data from 52 differently managed grassland and forest soils in three study regions spanning a latitudinal gradient in Germany. We hypothesize that, after extraction of variation that is

We have studied the geometry and singlet-triplet energy difference of two mono-nuclear Ni2+ models related to the active site in [NiFe] hydrogenase. Multiconfigurational second-order perturbation theory based on a complete active-space wavefunction with an active space of 12 electrons in 12 orbitals, CASPT2(12,12), reproduces experimental bond lengths to within 1 pm. Calculated singlet-triplet ene

OBJECTIVES: Mental ill-health has become a large health problem and it is important for caregivers to provide effective treatment alternatives. REGASSA is a randomized controlled study performed in primary care to study the effects of 12 weeks of Internet-based cognitive behaviour therapy (ICBT) and physical exercise (PE) compared with treatment as usual (TAU) in patients with mild-to-moderate men

Reconstructions of the geomagnetic field in the past represent a useful tool not only to investigate the geodynamo process, but also to estimate the effect of geomagnetic shielding for any studies on cosmogenic radionuclides and galactic cosmic rays. A number of new millennial-scale geomagnetic field reconstructions have been published over the last years, based on improved global archeo- and pale

This paper presents a probabilistic approach to analyse evacuation movement data. The approach relies on a detailed video analysis of people movement and pattern reconstruction. Conditional probabilities for travel path trajectories, walking speeds, and physical area occupied on stair landings are calculated for the evacuee population. The approach has been applied as a case study using data from

This study addresses development of a content-valid cross-Nordic version of the Housing Enabler and investigation of its inter-rater reliability when used in occupational therapy rating situations, involving occupational therapists, clients, and their home environments. The instrument was translated from the original Swedish version of the Housing Enabler, and adapted according to accessibility no

The application of treated sewage sludge on farmland is a suggested method for recycling nutrients and reducing demand for commercial fertilizer. However sludge needs to be safe from possible contaminants which can cause acute and long-term health and environmental problems. Residual pharmaceuticals and organic contaminants are mentioned as emerging threats since wastewater treatment plants are no

Popular Abstract in Swedish Avhandlingen studerar flera olika algoritmiska problem inom grafteori och geometri, applikationerna sträcker sig från kretskortsdesign till matrismultiplikation. Vi börjar med att studera en grafteoretisk modell för det så kallade "firefigher problem". Målet med detta problemet är att rädda så mycket som möjligt av en given area genom att placera ut brandmän på relevaThis thesis studies several different algorithmic problems in graph theory and in geometry. The applications of the problems studied range from circuit design optimization to fast matrix multiplication. First, we study a graph-theoretical model of the so called ''firefighter problem''. The objective is to save as much as possible of an area by appropriately placing firefighters. We provide both n