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Founder events predict changes in genetic diversity during human-mediated range expansions

Intentional or accidental introduction of species to new locations is predicted to result in loss of genetic variation and increase the likelihood of inbreeding, thus reducing population viability and evolutionary potential. However, multiple introductions and large founder numbers can prevent loss of genetic diversity and may therefore facilitate establishment success and range expansion. Based o

Methodology for evaluating effects of material characteristics on machinability-theory and statistics-based modelling applied on Alloy 718

The potential machinability for Alloy 718 (Inconel 718) is examined in terms of five material characteristics considered to play a key role in the machinability: ductility (elongation to fracture), strain hardening (ultimate tensile strength over yield strength), thermal conductivity, yield strength and abrasiveness (amount of carbides). The material characteristics are simulated with the software

On the Analysis of the Cr-Cr Multiple Bond in Several Classes of Dichromium Compounds

Since the discovery of a formal quintuple bond in Ar'CrCrAr' (CrCr = 1.835 angstrom) by Power and co-workers in 2005, many efforts have been dedicated to isolating dichromium species featuring quintuple-bond character. In the present study we investigate the electronic configuration of several, recently synthesized dichromium species with ligands using nitrogen to coordinate the metal centers. The

Real-time use of instantaneous wave-free ratio: Results of the ADVISE in-practice: An international, multicenter evaluation of instantaneous wave-free ratio in clinical practice

Objectives To evaluate the first experience of real-time instantaneous wave-free ratio (iFR) measurement by clinicians. Background The iFR is a new vasodilator-free index of coronary stenosis severity, calculated as a trans-lesion pressure ratio during a specific period of baseline diastole, when distal resistance is lowest and stable. Because all previous studies have calculated iFR offline, the

Search for third generation scalar leptoquarks in pp collisions at root s=7 TeV with the ATLAS detector

A search for pair-produced third generation scalar leptoquarks is presented, using proton-proton collisions at root s = 7 TeV at the LHC. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 4.7 fb(-1). Each leptoquark is assumed to decay to a tau lepton and a b-quark with a branching fraction equal to 100%. No statistically significant excess above the Stan

Comparison of two commonly used reference materials for exercise bicycle tests with a Swedish clinical database of patients with normal outcome

Background: Reference values for working capacity, blood pressure, heart rate, perceived exertion, etc. during bicycle exercise tests have been sought after for many years. This is because earlier commonly used reference values for physical work capacity have been either too low or too high when compared to the clinical experience of several Swedish departments of clinical physiology. The aim of t

Transition in Yield and Azimuthal Shape Modification in Dihadron Correlations in Relativistic Heavy Ion Collisions

Hard-scattered parton probes produced in collisions of large nuclei indicate large partonic energy loss, possibly with collective produced-medium response to the lost energy. We present measurements of pi(0) trigger particles at transverse momenta p(T)(t) = 4-12 GeV/c and associated charged hadrons (p(T)(a) = 0.5-7 GeV/c) vs relative azimuthal angle Delta phi in Au + Au and p + p collisions at roo

New methods to identify conserved microsatellite loci and develop primer sets of high cross-species utility - as demonstrated for birds

We have developed a new approach to create microsatellite primer sets that have high utility across a wide range of species. The success of this method was demonstrated using birds. We selected 35 avian EST microsatellite loci that had a high degree of sequence homology between the zebra finch Taeniopygia guttata and the chicken Gallus gallus and designed primer sets in which the primer bind sites

Molecularly imprinted polymers for histamine recognition in aqueous environment

Molecularly imprinted polymers (MIP) for histamine using methacrylic acid were developed and recognition mechanisms were thoroughly characterized for the first time in this study. The binding affinity of imprinted polymer with structurally related compounds was studied in organic and aqueous media, at various conditions. In organic media, MIP was found to bind histamine two and six times more than

Impact of seeding on the start-up of one-stage deammonification MBBRs.

Treating nitrogen-rich reject water from anaerobically digested sludge with deammonification has become a very beneficial side stream process. One common technique is the one-stage moving bed bioreactors (MBBRs), which in comparison with the other deammonification techniques can be started up without seeding anammox bacteria. This study investigated the impact of biofilm seeding on the start-up of

Quantitative proteomics targeting classes of motif-containing peptides using immunoaffinity-based mass spectrometry.

The development of high-performance technology platforms for generating detailed protein expression profiles, or protein atlases, is essential. Recently, we presented a novel platform that we termed global proteome survey (GPS), where we combined the best features of affinity proteomics and mass spectrometry, to probe any proteome in a species independent manner while still using a limited set of

Semantic Holism and Language Learning

Holistic theories of meaning have, at least since Dummett’s Frege: The Philosophy of language, been assumed to be problematic from the perspective of the incremental nature of natural language learning. In this essay I argue that the general relationship between holism and language learning is in fact the opposite of that claimed by Dummett. It is only given a particular form of language learning,

Apolipoprotein B, the villain in the drama?

Low-density lipoprotein (LDL) is the major atherogenic lipoprotein and the primary target of lipid-lowering therapy for treating ischemic cardiovascular disease. Apolipoprotein B (apoB), an important structural component of LDL, plays a key role in cholesterol transport and removal in vascular wall. On the other hand, under pathological process, apoB interacts with the arterial wall to initiate th

Tourist Place-Making in Practice

Tourist attractions emerge in stakeholder negotiation processes, where a critical issue is how different notions of meaning and value are argued and expressed. This article investigates this process of meaning production in practice through four examples of tourist attraction developments in Southern Sweden. Instances where tourist attractiveness is defined by stakeholders are analyzed by showing

Construction and Characterization of Kilobasepair Densely Labeled Peptide-DNA

Directed assembly of biocompatible materials benefits from modular building blocks in which structural organization is independent of introduced functional modifications. For soft materials, such modifications have been limited. Here, long DNA is successfully functionalized with dense decoration by peptides. Following introduction of alkyne-modified nucleotides into kilobasepair DNA, measurements

Selective oxidation of trimethylolpropane to 2,2-bis(hydroxymethyl)butyric acid using growing cells of Corynebacterium sp. ATCC 21245.

Multifunctional chemicals including hydroxycarboxylic acids are gaining increasing interest due to their growing applications in the polymer industry. One approach for their production is a biological selective oxidation of polyols, which is difficult to achieve by conventional chemical catalysis. In the present study, trimethylolpropane (TMP), a trihydric alcohol, was subjected to selective oxida

Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study.

Gene-environment interactions need to be studied to better understand the obesity. We aimed at determining whether genetic susceptibility to obesity associates with diet intake levels and whether diet intakes modify the genetic susceptibility. In 29,480 subjects of the population-based Malmö Diet and Cancer Study (MDCS), we first assessed association between 16 genome-wide association studies iden

One Last Opportunity: Swedish Nurses' Experiences of Palliative Sedation

Palliative sedation is used as a form of treatment within palliative care in Sweden. Previous research shows that palliative sedation raises many ethical concerns for both physicians and nurses. The purpose of this study was to illuminate nurses' experiences of palliative sedation in specialist palliative care. Fourteen semistructured interviews were conducted and analyzed using Burnard's qualitat

Substrate-selective catalysis.

Substrate selectivity is an important output function for the validation of different enzyme models, catalytic cavity compounds, and reaction mechanisms as demonstrated in this review. In contrast to stereo-, regio-, and chemoselective catalysis, the field of substrate-selective catalysis is under-researched and has to date generated only a few, but important, industrial applications. This review