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De GRACILA barnen

GRACILE-syndromet (Fellmans syndrom, MIM 603358) hör till det fi nländska genetiska sjukdomsarvet. Sjukdomen är orsakad av en missens mutation (S78G) i BCS1L, ett protein som fungerar som en “chaperon” eller sammankopplande länk vid bildning av komplex III i andningskedjan. Syndromet uttrycker sig som en grav tillväxthämning redan under fostertiden, och efter födseln utvecklar barnet en uttalad me

A methodology for estimation of mass transfer parameters in a detailed chromatography model based on frontal experiments

A methodology for estimation of the unknown physical parameters in a detailed model for chromatographic processes is proposed. The model describes the concentration of the solute in the mobile phase and considers external/internal mass transfer resistance. The external volume and its mixing effect are also considered. The unknown model parameters estimated are the bed void, the axial dispersion co

Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by Alpha-Synuclein Protofibrils

alpha-Synuclein (alpha-Syn) accounts, as a major component of Lewy bodies (LB), for the filamentous deposits in many cases of neurodegenerative diseases. Yet, little is known about the molecular mechanisms of neuronal loss in these diseases. The correlation between alpha-Syn oligomerization/aggregation and pathologies raises the key question of which molecular form of alpha-Syn (i.e. monomeric alp

Exploring experience of family relations by patients with anorexia nervosa and bulimia nervosa using a projective family test.

Elements of family dynamics have been shown to be related to onset, course, as well as prognosis of anorexia nervosa and bulimia nervosa. The goal was to explore the experience of family relations in a group of patients with eating disorders using a projective family test. The Patient group (anorexia=21, bulimia=16), as well as a healthy Control group, were given a projective family test, the Eati

Carrier-envelope phase stabilization of a multi-millijoule, regenerative-amplifier-based chirped-pulse amplifier system

This article reports on the successful stabilization of the carrier-envelope phase of a 1-kHz laser system that includes a large grating stretcher, a regenerative amplifier, a multipass amplifier and a grating compressor. Phase stability for pulse energies up to 6 mJ is demonstrated using electronic feedback to the oscillator locking electronics as well as feedback via an acousto-optic programmabl

Gruppdagbok i forskning och praktik – en metod för gruppstudier

A new method for collection of group data is described— Group Diary. Document studies in psychology are a background. Group members collect data as recorders and synthesize their notes. The method is a tool for learning, research and consultation. Methodological issues are elucidated. After presentation of five studies on group formation and development done by the authors, the pros and cons of th

Effects in vitro and in vivo by apomorphine in the rat corpus cavernosum.

1 The study was performed to clarify if apomorphine at the level of the rat corpus cavernosum can produce erectile responses or interfere with nerve-induced penile erection. 2 Apomorphine ( 10(-9) - 10(-4) M) exhibited a 10-fold higher potency to relax phenylephrine ( Phe)-than endothelin-1 ( ET-1)-induced contractions. Relaxant effects of apomorphine in Phe-activated corpus cavernosum did not cha

Evaluation of Systolic and Diastolic Hypotension in Dementia with Lewy Bodies and Alzheimer’s Disease.

BACKGROUND: Orthostatic hypotension (OH) can be seen in as many as 30% to 50% of the elderly population as well as in dementia. OH is part of the autonomic dysfunction in dementia with Lewy bodies (DLB) and prevalent in the majority of these patients. It is also suggested to be a negative prognostic factor for survival in DLB. A detailed interpretation of the 10-minute orthostatic blood pressure m

The ATLAS Experiment at the CERN Large Hadron Collider

The ATLAS detector as installed in its experimental cavern at point 1 at CERN is described in this paper. A brief overview of the expected performance of the detector when the Large Hadron Collider begins operation is also presented.

Complex Span Versus Updating Tasks of Working Memory: The Gap Is Not That Deep

How to best measure working memory capacity is an issue of ongoing debate. Besides established complex span tasks, which combine short-term memory demands with generally unrelated secondary tasks, there exists a set of paradigms characterized by continuous and simultaneous updating of several items in working memory, such as the n-back, memory updating, or alpha span tasks. With a latent variable

Diamonds or development? A structural assessment of Botswana's forty years of success

Due to its four decades of high long-term economic growth and democratic system, Botswana has been depicted as an exceptional success story in a region full of economic and political failures. In this article,,a structural analysis is applied, and it is argued that Botswana's success should be understood as one of pre-modern growth without development. It is claimed that although the country may b