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For hemophilia patients with inhibitors, immune tolerance induction (ITI) may help to restore clinical response to Factor (F) VIII or FIX concentrates. Several ITI regimens and protocols exist; however, despite 30 yr of progressive investigation, the ITI evidence base relies mainly on observational data. Expert opinion, experience, and interpretation of the available evidence are therefore valuabl

OBJECTIVE: To date, for detection of the absence of peristalsis in children with chronic constipation and a suspicion of Hirschsprung disease (HD), children have been investigated with a contrast enema. If the radiographic investigation is inconclusive, anometry and a rectal biopsy are performed. A new noninvasive real-time sonographic method for examination of the rectoanal inhibitory reflex (RAI

Interaural attenuation (IA) was evaluated for pure tones (frequency range 125 to 16000 Hz) using Sennheiser HDA 200 circumaural earphones and Telephonics TDH-39P earphones in nine unilaterally deaf subjects. Audiometry was conducted in 1-dB steps using the manual ascending technique in accordance with ISO 8253-1. For all subjects and for all tested frequencies, the lowest IA value for HDA 200 was

Despite that epidemiological studies did not indicate negative effects on neurological development of offspring when exposed to diagnostic ultrasound, possible association with nonright-handedness in males could not be excluded. In addition, an experimental study on fetal mice suggested that prolonged ultrasound exposure may cause mild disturbance in neuronal migration. No doubt, further studies a

The subject of study is the emission of Volatile Organic Compounds (VOC) during the drying of wood. Heartwood and sapwood from Scots pine were dried at different temperatures (50, 70 and 90°C) in a laboratory kiln. The sampling method, Solid Phase Microextraction was used to collect the different volatile organic compounds during the drying. The gas chromatograph and mass spectrometer was used to

Hepatoblastomas usually occur in children < 3 years of age, and only occasional adult cases have been described. To date, 20 cytogenetically abnormal childhood hepatoblastomas have been reported. Karyotypic investigations have shown that most hepatoblastomas are diploid or hyperdiploid, often displaying trisomies for chromosomes 2 and 20. We have cytogenetically investigated an adult hepatoblastom

Pseudomonas aeruginosa attracts research attention as a common opportunistic nosocomial pathogen causing severe health problems in humans. Nevertheless, its primary habitat is the natural environment. Here, we relate the genetic diversity of 381 environmental isolates from rivers in northern Germany to ecological factors such as river system, season of sampling and different levels of water qualit

Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) than with other kinds of wound management. We have recently shown that NPWT decreases the blood flow in the intestinal wall, and that the blood flow could be restored by inserting a protective disc over the intestines. The aim of the present study was to investigate whether layers of Jelonet™ (S

Nuclear structure information available to September 1979 has been reviewed. Results from reaction and decay studies are presented together with adopted level properties.

We study the intensity dependence of ionization and fragmentation of buckminsterfullerene (C-60) in strong laser fields. Our data provide strong evidence that at intensities less than or similar to 10(14) W/cm(2) these processes occur predominantly via multiphoton excitation of the 20 eV plasmon resonance of C-60 At least two plasmons have to be created to initiate fragmentation or multiple ioniza

Von Willebrand Disease (VWD) is the most common inherited bleeding disorder. Measurement of von Willebrand factor (VWF) activity in plasma is often based on platelet agglutination stimulated by the ristocetin cofactor activity. Novel assays, based on latex beads with recombinant glycoprotein Ib instead of platelets, have recently been developed but it is unclear whether these can improve the diagn