We present a high-resolution magnesium/calcium proxy record of Holocene sea surface temperature (SST) from off the west coast of Baja California Sur, Mexico, a region where interannual SST variability is dominated today by the influence of the El Nino-Southern Oscillation (ENSO). Temperatures were lowest during the early to middle Holocene, consistent with documented eastern equatorial Pacific coo

Loss of biodiversity in European farmland has been attributed to agricultural intensification and the resulting loss of ecological heterogeneity. To alleviate the effect of agricultural intensification, farmers are compensated via agri-environment schemes for carrying out farming in ways to preserve and restore biodiversity. However, the effectiveness of these schemes has been questioned and evalu

We present a detailed theoretical study of the electronic spectrum and Zeeman splitting in hole quantum wires. The spin-3/2 character of the topmost bulk-valence-band states results in a strong variation in subband-edge g factors between different subbands. We elucidate the interplay between quantum confinement and heavy-hole-light-hole mixing and identify a certain robustness displayed by low-lyi

Background: The transcription factor SOX11 is of diagnostic and prognostic importance in mantle cell lymphoma (MCL) and epithelial ovarian cancer (EOC), respectively. Thus, there is an unmet clinical and experimental need for SOX11-targeting assays with low background, high specificity and robust performance in multiple applications, including immunohistochemistry (IHC-P) and flow cytometry, which

Whereas fossil evidence indicates extensive treeless vegetation and diverse grazing megafauna in Europe and northern Asia during the last glacial, experiments combining vegetation models and climate models have to-date simulated widespread persistence of trees. Resolving this conflict is key to understanding both last glacial ecosystems and extinction of most of the mega-herbivores. Using a dynami

OBJECTIVETo identify the clinical and genetic factors that explain why the rate of diabetes progression is highly variable between idividuals following diagnosis of type 2 diabetes.RESEARCH DESIGN AND METHODSWe studied 5,250 patients with type 2 diabetes using comprehensive electronic medical records in Tayside, Scotland, from 1992 onward. We investigated the association of clinical, biochemical,

Adopting the hypothesis about the exact cancellation of vacuum condensates contributions to the ground state energy in particle physics to the leading order in graviton-mediated interactions, we argue that the observable cosmological constant can be dynamically induced by an uncompensated quantum gravity correction to them after the QCD phase transition epoch. To start with, we demonstrate a possi

Artikeln behandlar transatlantiskt slaveri från 1400-talet till 1800-talet.

Objective: Systemic lupus erythematosus (SLE) is a complex multi-organ disease, characterised by relapses and remissions. Designing a high-quality randomised controlled trial poses many challenges. We have developed evidenced-based recommendations for points to consider in conducting clinical trials in patients with SLE. Methods: The EULAR Task Force on SLE comprised 19 specialists and a clinical

Internal dynamics of dansylated poly(propyleneamine) dendrimers (POPAM, G1-G4) in solution and excitation energy transfer from dansyls to eosin in POPAM-eosin complexes have been studied by time-resolved fluorescence spectroscopy and molecular dynamics (MD) simulations. Combining the results from fluorescence anisotropy and the MD simulation studies suggests three time domains for the internal dyn

Early diagnosis of severe infectious diseases is essential for timely implementation of lifesaving therapies. In a search for novel biomarkers in sepsis diagnosis we focused on polymorphonuclear neutrophils (PMNs). Notably, PMNs have their protein cargo readily stored in granules and following systemic stimulation an immediate increase of neutrophil-borne proteins can be observed into the circulat

We present a deterministic algorithm that given any directed graph on n vertices computes the parity of its number of Hamiltonian cycles in O(1.619n) time and polynomial space. For bipartite graphs, we give a 1.5npoly(n) expected time algorithm. Our algorithms are based on a new combinatorial formula for the number of Hamiltonian cycles modulo a positive integer.

Zinc protoporphyrin is formed in pork homogenates in both enzymatic and non-enzymatic reactions. Ferrochelatase is active in formation of the highly fluorescent pigment known from Parma ham as demonstrated by inhibition with N-methylmesoporphyrin and by thermal inactivation. A non-enzymatic transmetallisation reaction, exchange of iron in myoglobin by zinc(II), is demonstrated by Pb(II) inhibition