Increased PDGFRA signaling is an essential pathogenic factor in many subtypes of gliomas. In this context the cell surface expression of PDGFRA is an important determinant of ligand sensing in the glioma microenvironment. However, the regulation of spatial distribution of PDGFRA in glioma cells remains poorly characterized. Here, we report that cell surface PDGFRA expression in gliomas is negative

Our knowledge about acute promyelocytic leukemia (APL) patients is mainly based on data from clinical trials, whereas population-based information is scarce. We studied APL patients diagnosed between 1997 and 2006 in the population-based Swedish Adult Acute Leukemia Registry. Of a total of 3897 acute leukemia cases, 3205 (82%) had non-APL acute myeloid leukemia (AML) and 105 (2.7%) had APL. The in

Mammography screening can reduce breast cancer mortality. The aim of the present study was to investigate non-attendance in mammography screening in relation to different aspects of a women's social network, attitudes and cancer in close relations.

The serum PSA test still is the most important biomarker for the detection and follow-up of prostate cancer. PSA-based screening can reduce disease specific mortality but coinciding unnecessary testing and overdiagnosis warrant further research for more specific biomarkers. Numerous studies of both serum and urine-based prostate cancer biomarker candidates have been presented the last ten years. H

Context. Possible main formation sites of fluorine in the Universe include asymptotic giant branch (AGB) stars, the v-process in Type II supernova, and/or Wolf-Rayet stars. The importance of the Wolf-Rayet stars has theoretically been questioned and they are probably not needed in modeling the chemical evolution of fluorine in the solar neighborhood. It has, however, been suggested that Wolf-Rayet

Single-shaft gas turbines are sensitive to frequency changes which might affect the grid stability during large frequency drops. This paper presents a new control system that uses steam injection as an auxiliary input to improve the transient performance of the gas turbine during frequency drops. Steam injection is beneficial because it reduces the peak temperature in the combustion chamber and au

The leadership literature is full of stories of heroic self-sacrifice. Sacrificial leadership behaviour, some scholars conclude, is to be recommended. In this article we follow Keith Grint's conceptualization of leadership as necessarily pertaining to the sacred, butdrawing on Giorgio Agamben's notion of profanationwe highlight the need for organization scholars to profane the sacralizations embed

The need for reliable measurement of droplet velocities and droplet size has increased with the more widespread use of water mist systems. Two optical measuring techniques have been investigated, Particle Image Velocimetry (PIV) and phase Doppler anemometry (PDA). Measurements have been performed on two high-pressure nozzles, a hollow cone nozzle and a full cone nozzle. Both methods performed well

The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). (I and II) Autoantibodies to the C3 cleaving enzyme complex of the alternative pathway, C3 nephritic facto

Background Ischemic heart disease and stroke are two severe types of cardiovascular disease (CVD), a major contributor to the global burden of disease. The preventive framework currently includes promotion of both adequate cardiorespiratory and muscular fitness. Although muscle fitness is established as an indicator of health, it is currently unknown whether muscle strength is associated with lat

Naturligt urval som en drivande evolutionär kraft accepterades fullt under 1930- och 40-talen sedan darwinistisk selektionsteori kunnat förenas med Mendels ärftlighetslagar. Men modern evolutionsteori utvecklas kontinuerligt. Den darwinistiska evolutionsteorin med sina förgreningsmodeller förklarar mångfalden av levande organismer och deras anpassning till miljön. Moderna sammanslutningar som Tree

Background. There has been little research on how late-life frailty interrelates with sexual health. Our objective was to examine the association of frailty with sexual functioning and satisfaction among older men. Methods. The study population consisted of 1,504 men aged 60 to 79 years, participating in the European Male Aging Study. Self-report questionnaires measured overall sexual functioning,

A readily mass-producible, flip-chip assembled, and slot-coupled III-V compound semiconductor dielectric resonator antenna operating in the millimeter-wave spectrum has been fabricated and characterized. The antenna has a 6.1% relative bandwidth, deduced from its 10 dB return loss over 58.8-62.5 GHz, located around the resonance at 60.5 GHz. Gating in the delay-domain alleviated the analysis of th

Poisson's ratio of an isotropic and free elastic plate is estimated from the polarization of the first symmetric acoustic zero-group velocity Lamb mode. This polarization is interpreted as the ratio of the absolute amplitudes of the surface normal and surface in-plane components of the acoustic mode. Results from the evaluation of simulated datasets indicate that the presented relation, which link

Background The expression levels of LPL, ZAP70, TCL1A, CLLU1 and MCL1 have recently been proposed as prognostic factors in chronic lymphocytic leukemia. However, few studies have systematically compared these different RNA-based markers. Design and Methods Using real-time quantitative PCR, we measured the mRNA expression levels of these genes in unsorted samples from 252 newly diagnosed chronic ly

Introduction: Hypertensive encephalopathy is one cause of posterior reversible encephalopathy syndrome. Hypertensive encephalopathy and cerebral infarction have only been reported in a few individual case reports. Case description: A 51-year-old woman presented with hypertensive encephalopathy. T2-weighted images from magnetic resonance imaging showed hyperintense lesions in both occipital and par

Subcycle strong-field ionization (SFI) underlies many emerging spectroscopic probes of atomic or molecular attosecond electronic dynamics. Extending methods such as attosecond high harmonic generation spectroscopy to complex polyatomic molecules requires an understanding of multielectronic excitations, already hinted at by theoretical modeling of experiments on atoms, diatomics, and triatomics. He

Recently, the supersymmetry method was extended from Gaussian ensembles to arbitrary unitarily invariant matrix ensembles by generalizing the Hubbard-Stratonovich transformation. Here, we complete this extension by including arbitrary orthogonally and unitary-symplectically invariant matrix ensembles. The results are equivalent to, but the approach is different from, the superbosonization formula.