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While tau pathology is closely associated with neurodegeneration in Alzheimer's disease (AD), our prior work using multi-modality imaging revealed that mismatch between tau (T) and neurodegeneration (N) may reflect contributions from non-AD processes. The medial temporal lobe (MTL), an early site of AD pathology, is also a common target of co-pathologies such as limbic-predominant age-related TDP-
Abstract – Background: Cytological examination of a fine-needle aspirate (FNA) is a minimally invasive modality that is increasingly used in the diagnosis of lymphoma. Flow cytometry and other ancillary tests make an important contribution to the diagnostic value of FNAs of lymphoid lesions. This review follows the recent publication of the first edition of the WHO Reporting System for Lymph Node,
This pioneering volume explores complex local, global and digital contexts from the perspectives of Digital Theology.The use of and access to digital technology is highly contextual. It differs between regions, generations, classes, religious denominations, and gender. Which problems theologians claim to be important and which developments they ignore is contingent on their cultural, social, econo
This chapter gives an overview of the discussions on online preaching. It identifies and provides examples of three common approaches—message-oriented, media-oriented, and ontology-oriented. In addition, it points to a fourth approach that might be fruitful: the practice-oriented. The chapter also suggests four critical areas in which digital homiletics could benefit from being further developed:
Studies showing that large-scale public health interventions in early life have lastingconsequences are still scarce and rarely disclose the mechanisms. In 1931–1946, the Swedishstate reformed the childbirth institutional system that led to the openings of the new maternitywards and to the gradual decline in home deliveries assisted by midwives. Maternity wardsoffered improved conditions for a mot
Urban meteorology, the study of atmospheric phenomena in urban areas, is vital for understanding the dynamic interactions between rapid urbanization and environmental changes. Over the past two decades (2004–2024), urban heat islands (UHIs), extreme rainfall, pollution, and temperature anomalies have intensified, adversely affecting human health, infrastructure, and ecosystems worldwide. The prese
Breastfeeding confers a wide range of benefits to mothers and children, and in many contextsmay continue for several years after the birth of a child. As a result, breastfeeding duringpregnancy (BDP) is a common occurrence throughout low- and middle-income countries.Nevertheless, yet there has been little research into its association with the health of breastfedchildren or the outcomes of the pre
The high prevalence (>5%) of autoimmune hypothyroidism (AIHT) provides a unique opportunity to dissect genetic contributions to systemic and organ-specific autoimmunity. Here we performed a genome-wide association meta-analysis of 81,718 AIHT cases in FinnGen and the UK Biobank, identifying 418 independent signals (P < 5 × 10−8). At 48 of these loci, a protein-coding variant is, or is highly corre
BACKGROUND: Familial aggregation of stroke is well-documented, yet few studies have examined associations between stroke subtypes-particularly early-onset cryptogenic ischaemic stroke (eCIS)-and broader family history (FH) of cardiovascular disease. Such associations may provide insights into underlying etiologic mechanisms. METHODS: In this multicentre case-control study, we included eCIS patient
We address discrete-time consensus on the Euclidean unit sphere. For this purpose we consider a distributed algorithm comprising the iterative projection of a conical combination of neighboring states. Neighborhoods are represented by a strongly connected directed graph, and the conical combinations are represented by a (non-negative) weight matrix with a zero structure corresponding to the graph.
The conservation community sorely lacks a global indicator of change in insect populations. Given widespread insect declines, addressing this gap is key for conservation and policy targets. We suggest that butterfly monitoring programs can serve as the foundation for an effective global network of insect monitoring. To assess this potential, we bring together an international consortium and calcul
Increasing frequency and intensity of droughts threaten grassland ecosystems. Semi-natural grasslands vary in age from ancient to younger sites established on former arable land. While species richness and composition are known to affect drought resilience, little is known about how grassland age shapes drought responses through eco-evolutionary processes at the plant population level. We explored
Chemical communication is the oldest and most widespread form of signalling among and within organisms. Among the many compounds involved in such communication, pyrazines – nitrogen-containing heterocyclic molecules – are especially intriguing due to their widespread occurrence across the tree of life, from bacteria and fungi to insects and mammals. In this review, we focus on the role of pyrazine
Methacrylated Pluronic triblock copolymers are widely used as photo-cross-linkable hydrogels, yet the effect of terminal methacrylation on self-assembly and thermoreversible gelation prior to cross-linking remains poorly understood. Here, we systematically investigate how the degree of methacrylation influences micellization, micelle packing, and gelation in Pluronic F127 using differential scanni
Technological advances in computed tomography (CT) have highlighted limitations of traditional dose descriptors such as computed tomography dose indexvol and dose-length product, particularly for wide-beam and modulated acquisitions. This study investigates a CT-specific, operational air kerma–area product derived from time-resolved measurements using small solid-state dosemeters mounted at the ga
