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Systematic study of azimuthal anisotropy in Cu plus Cu and Au plus Au collisions at root s(NN)=62.4 and 200 GeV

We have studied the dependence of azimuthal anisotropy nu(2) for inclusive and identified charged hadrons in Au + Au and Cu + Cu collisions on collision energy, species, and centrality. The values of nu(2) as a function of transverse momentum pT and centrality in Au + Au collisions at root s(NN) = 200 and 62.4 GeV are the same within uncertainties. However, in Cu + Cu collisions we observe a decre

Common sequence variants on 20q11.22 confer melanoma susceptibility

We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger assoc

Low-lying states in near-magic odd-odd nuclei and the effective interaction

The iterative quasiparticle random-phase approximation (QRPA) method we previously developed [Phys. Rev. C 81, 034312 (2010); 86, 024303 (2012); 86, 014307 (2012)] to accurately calculate properties of individual nuclear states is extended so that it can be applied for nuclei with odd numbers of neutrons and protons. The approach is based on the proton-neutron QRPA (pnQRPA) and uses an iterative n

Rao-Blackwellized Auxiliary Particle Filters for Mixed Linear/Nonlinear Gaussian models

The Auxiliary Particle Filter is a variant of the common particle filter which attempts to incorporate information from the next measurement to improve the proposal distribution in the update step. This paper studies how this can be done for Mixed Linear/Nonlinear Gaussian models, it builds on a previously suggested method and introduces two new variants which tries to improve the performance by u

Batch- and continuous propionic acid production from glycerol using free and immobilized cells of Propionibacterium acidipropionici

Propionicacid production from glycerol was studied using Propionibacterium acidipropionici DSM 4900 cells immobilized on polyethylenimine-treated Poraver (PEI-Poraver) and Luffa (PEI-Luffa), respectively. Using PEI-Luffa, the average productivity, yield and concentration of propionicacid from 40 g.L-1 glycerol were 0.29 g.L-1.h-1, 0.74 mol.mol-1 and 20.09 g.L-1, respectively, after four consecutiv

Human Chemokines as Antimicrobial Peptides with Direct Parasiticidal Effect on Leishmania mexicana In Vitro.

Chemokines and chemokine receptor-mediated effects are important mediators of the immunological response and cure in human leishmaniasis. However, in addition to their signalling properties for leukocytes, many chemokines have also been shown to act directly as antimicrobial peptides on bacteria and fungi. We screened ten human chemokines (CXCL2, CXCL6, CXCL8, CXCL9, CXCL10, CCL2, CCL3, CCL20, CCL

Theoretical considerations for understanding a Purkinje cell timing mechanism

In classical conditioning, cerebellar Purkinje cells learn an adaptively timed pause in spontaneous firing. This pause reaches its maximum near the end of the interstimulus interval. While it was thought that this timing was due to temporal patterns in the input signal and selective engagement of changes in synapse strength, we have shown Purkinje cells learn timed responses even when the conditio

Photoelectrochemical Communication between Thylakoid Membranes and Gold Electrodes through Different Quinone Derivatives

Photosynthesis is a sustainable process for the conversion of light energy into chemical energy. Thylakoids in energy-transducing photosynthetic membranes are unique in biological membranes because of their distinguished structure and composition. The quantum trapping efficiency of thylakoid membranes is appealing in photobioelectrochemical research. In this study, thylakoid membranes extracted fr

Heterogeneous genetic profiles in soft tissue myoepitheliomas

Myoepithelioma, mixed tumor and parachordoma are uncommon soft tissue tumors thought to represent morphological variants of a single tumor type. The genetic basis of these neoplasms is poorly understood. However, they morphologically resemble mixed tumor of the salivary glands (also known as pleomorphic adenoma), a tumor characterized by deregulated expression of PLAG1 or HMGA2. To evaluate a poss

Thought-Images: The Quest for Visualisation of the Mental around 1900

This article examines the ever-actual desire to visualise and materialise thought-images in a historical perspective. The interest for research into thought imagery,and of visual proof production of thoughts, coincided with the invention of the camera and culminated somewhere around 1900. Together with other scientific circumstances that appeared up to 1900, such as the experimental psychology mod

Feedbacks and Interactions: From the Arctic Cryosphere to the Climate System

Changes in the Arctic's climate are a result of complex interactions between the cryosphere, atmosphere, ocean, and biosphere. More feedbacks from the cryosphere to climate warming are positive and result in further warming than are negative, resulting in a reduced rate of warming or cooling. Feedbacks operate at different spatial scales; many, such as those operating through albedo and evapotrans

Self-powered wireless carbohydrate/oxygen sensitive biodevice based on radio signal transmission.

Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell ge

Reaching beyond HIV/HCV: nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus

Drug repurposing or re-profiling has become an effective strategy to identify novel indications for already-approved drugs. In this study, peptidomimetic FDA-approved HIV/HCV inhibitors were explored for their potential to be repurposed for the inhibition of the replication of dengue (DENV) and chikungunya virus (CHIKV) by targeting the NS2B-NS3 and NSP2 protease, respectively. MM/GBSA-based bindi

A synthetic globotriaosylceramide analogue inhibits HIV-1 infection in vitro by two mechanisms

Previously, it was shown that the cell-membrane-expressed glycosphingolipid, globotriaosylceramide (Gb(3)/P-k/CD77), protects against HIV-1 infection and may be a newly described natural resistance factor against HIV infection. We have now investigated the potential of a novel, water soluble, non-toxic and completely synthetic analogue of Gb(3)/P-k (FSL-Gb(3)) to inhibit HIV-1 infection in vitro.