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Elderly individuals with diabetes and foot ulcer have a probability for healing despite extensive comorbidity and dependency

Background: Limited scientific evidence for prevention and treatment of diabetic foot ulcers in elderly with comorbidities. Aim: To explore patient-related factors and outcomes in patients ≥75 years with diabetes and a foot ulcer. Method: Sub-analysis of consecutively presenting patients ≥75 years (N = 1008) from a previous study on 2,480 patients with diabetic foot ulcer treated in a multidiscipl

Expression of peritumoral SPARC during distal cholangiocarcinoma progression and correlation with outcome

Objectives: Distal cholangiocarcinoma (dCCA) is a malignancy with a dismal prognosis. One of the hallmarks is the presence of a rich desmoplastic stroma believed to contribute to tumor progression and treatment resistance. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein implicated in tumor-stroma interaction with prognostic correlation across several malignanci

The impact of initial treatment strategy and survival time on quality of end-of-life care among patients with oesophageal and gastric cancer : A population-based cohort study

BACKGROUND: Oesophageal and gastric cancer are highly lethal malignancies with a 5-year survival rate of 15-29%. More knowledge is needed about the quality of end-of-life care in order to understand the burden of the illness and the ability of the current health care system to deliver timely and appropriate end-of-life care. The aim of this study was to describe the impact of initial treatment str

Sofiero park : A historic building renovation with optimising photovoltaics according to hourly load profile

Retrofitting historical buildings was neglected for many years, as common systems could not be used. Now that technology has evolved, retrofitting buildings worth preserving is getting more common and can play a significant role in reaching climate targets by reducing the energy use. In order to produce equally much or more energy as the respective buildings use renewably and on site, the exploita

Compressively-strained GaSb nanowires with core-shell heterostructures

GaSb-based nanowires in a gate-all-around geometry are good candidates for binary p-type transistors, however they require the introduction of compressive strain to enhance the transport properties. Here, we for the first time demonstrate epitaxial GaSb-GaAsxSb1−x core-shell nanowires with a compressively strained core. Both axial and hydrostatic strain in GaSb core have been measured by X-ray dif

Fracture characteristics of acetylated young Scots pine

A study on the fracture characteristics of unmodified and chemically modified Scots pine (Pinus sylvestris) is presented. The investigated material consisted of small-dimension sawn timber originating from young logs (thinnings), aged 30–40 years. The modified samples were acetylated with acetic anhydride in an industrial scale process without the use of any catalyst, reaching an acetyl content of

Probabilistic Quantification Of Bias to Combine the Strengths Of Population-Based Register Data and Clinical Cohorts - Studying Mortality in Osteoarthritis

We propose to combine population-based register data, with a nested clinical cohort to correct misclassification and unmeasured confounding through probabilistic quantification of bias. We illustrate this approach by estimating the association between knee osteoarthritis and mortality. We used the Swedish Population Register to include all persons resident in the Skåne region in 2008 and assessed

The Latin and the Swedish Versions of J. Widekindi’s Historia Belli Sveco-Moscovitici Decennalis: the Nature of the Differences

Johannes Widekindi (c. 1620–78) was a Swedish historiographer of the Realm. His main work Historia Belli Sveco-Moscovitici Decennalis was published both in Latin and in Swedish (as Thet Swenska i Ryssland Tijo åhrs Krijgz-Historie). Although the Swedish edition appeared one year earlier than the Latin one, the latter is in no way a translation of the former. The textological relationship between t

Predictors and mediators of outcome in cognitive behavioral therapy for chronic pain: The contributions of psychological flexibility

There is now a consensus in the literature that future improvements in outcomes obtained from cognitive behavioral therapy (CBT) for chronic pain will requireresearch to identify patient and treatment variables that help explain outcomes. The frst aim of this study was to assess whether pre-treatment scores on measures of psychological (in)fexibility, acceptance, committed action, cognitive(de)fus

Polymer electrolyte fuel cell modeling - A comparison of two models with different levels of complexity

The modeling of fuel cells requires the coupling of fluid transport with electro-chemical reactions. There are two approaches commonly used. Firstly, the electrodes can be treated as two planes, where the potential gradient can be considered as being locally one-dimensional. In this case a two dimensional current density distribution is obtained. Secondly, the two electrode layers can be spatially

Hepcidin is a relevant iron status indicator in infancy : results from a randomized trial of early vs. delayed cord clamping

Background: We aimed to evaluate whether serum hepcidin is a useful indicator of iron status in infants. Methods: Term infants (n = 400) were randomized to delayed (≥180 s) or early (≤10 s) cord clamping (CC). Iron status was assessed at 4 and 12 months. In all cases with iron depletion or iron deficiency (ID) (as defined in “Methods”) (n = 30) and 97 randomly selected iron-replete infants, we ana

Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system

Fluid transport in the perivascular space by the glia-lymphatic (glymphatic) system is important for the removal of solutes from the brain parenchyma, including peptides such as amyloid-beta which are implicated in the pathogenesis of Alzheimer’s disease. The glymphatic system is highly active in the sleep state and under the influence of certain of anaesthetics, while it is suppressed in the awak

Loss of Cxcr5 alters neuroblast proliferation and migration in the aged brain

Neurogenesis, the production of new neurons from neural stem cells, dramatically decreases during aging concomitantly with increased inflammation both systemically and in the brain. However, the precise role of inflammation and whether local or systemic factors drive the neurogenic decline during aging is poorly understood. Here, we identify CXCR5/5/CXCL13 signaling as a novel regulator of neuroge

Finding Belonging, Finding Agency : Unaccompanied Refugee Minors Converting to Christianity in the Church of Sweden

The arrival 44,617 unaccompanied refugee minors (URM) to Sweden between 2014 and 2016 was met by a large number of civil society volunteers responding to their needs and assisting them in the early stages of their asylum processes, among them the Church of Sweden (CoS). What was not expected was that thousands of these Muslim-background young people would decide to convert to Christianity. Drawing

The road towards autonomous driving – A differentiated view of institutional agency in path transformation

The purpose of the article is to contribute to conceptual and empirical understandings of institutional agency in path transformation. Previous studies of links between institutional change and industrial transformation have focused mainly on the institutionalization of new practices and influence of territorially defined institutional preconditions, leaving a need to disentangle different types o

Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study

OBJECTIVE: The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second-appearing autoantibody and further progression to clinical disease in the Environmental Determinants of Diabetes in the Young study.RESEARCH DESIGN AND METHODS: Eligible children with increased HLA-DR-DQ genetic risk for T1

Conspiracy Beliefs Are Associated with Lower Knowledge and Higher Anxiety Levels Regarding COVID-19 among Students at the University of Jordan

The world has been afflicted heavily by the burden of coronavirus disease 2019 (COVID-19) that overwhelmed health care systems and caused severe economic and educational deficits, in addition to anxiety among the public. The main aim of this study was to evaluate the mutual effects of belief that the pandemic was the result of a conspiracy on knowledge and anxiety levels among students at the Univ

Word length effects on pictorial memory encoding in 5- to 7-year-old children: An eye-tracking study

How speech coding is used for visual material is critical to understanding the link between language and memory development. Using eye-tracking, the present study examined whether the number of syllables of pictured objects’ names, monosyllabic versus multisyllabic, predicts looking time at the stimuli-objects in the context of a memory task, thereby indicating verbal recoding. The children’s (N =