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Objectives: To describe a nationwide system for postmarketing follow up of new antirheumatic drugs in Sweden, and to analyse safety and effectiveness in an etanercept treated patient cohort. Methods: Etanercept became available in Sweden for prescribing on a named patient basis in 1999. All patients treated were included in a follow up of intensified adverse event reporting and recording of clinic
Over a period of three years, at least three different males of Common Redstarts Phoenicurus phoenicurus in southern Sweden mimicked the song of Scarlet Rosefinch Carpodacus erythrinus. At least two of the Redstarts were second calendar year birds that were heard to mimic Rosefinch song in spring long before the arrival of the local breeding population of Scarlet Rosefinch. Since Redstarts and Ros
Squid cranial cartilage has been found to contain three different proteoglycan populations, two of which form aggregates (Vynios, D.H. and Tsiganos, C. P., Biochim. Biophys. Acta 1033: 139-147, 1990). The aggregation involves interaction of their protein cores as assessed by electron microscopy and biochemical data. Aggregating oligopeptides were isolated after mild trypsin digestion which inhibit
This thesis concerns the numerical approximation of the solutions to hyperbolic conservation laws. In particular the research work focuses on reconstruction techniques; the reconstruction being the key ingredient in modern finite volume schemes aiming to increase spatial order of accuracy. To better conform to the nature of the solutions to the hyperbolic problems, the reconstructing fu
OBJECTIVES: To study the epidemiology of optic nerve hypoplasia. DESIGN AND METHODS: Children with optic nerve hypoplasia and visual impairment were identified through the Swedish Register of Visually Impaired Children. Pre- and perinatal characteristics were obtained from the Medical Birth Registry and by scrutinizing pregnancy and delivery records. Clinical characteristics of children with optic
The effect of mixing time on gluten formation was studied for four commercial flour mixtures. The gluten phase was separated from dough using a nondestructive ultracentrifugation method. Small I deformation dynamic theological measurements and light and scanning electron microscopy were used. The recovered gluten was relatively pure with a small amount of starch granules embedded. The protein matr
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Abstract is not available
The cAMP-elevating pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates insulin release in pancreatic B-cells. Here, we have investigated its potentiating action in rat insulinoma INS-1 cells. In intact cells, PACAP-27 (100 nM) stimulated glucose-induced insulin secretion by >60%. Using the patch-clamp technique with single-cell exocytosis monitored as increases in cell capacitanc
HIV-1 Nef has previously been shown to bind to Src homology-3 (SH3) domains of a subset of Src family tyrosine kinases. In addition, Nef has been reported to coprecipitate with a serine/threonine kinase activity termed NAK (for Nef-associated kinase). The identity of NAK remains uncertain, but it has been suggested to represent a novel member of the p21-activated kinase (PAK) family. We report her
Presents a method to use linear analysis to capture the frequency coupling of nonlinear and time-varying components. System stability is analyzed by connecting the harmonic transfer functions of the different component models. This facilitates an object-oriented approach to modeling, which supports reuse of models. An analysis of the complete railway system is, of course, difficult. Several locomo
Popular Abstract in Swedish Käkförsedda havsborstmaskar (polychaeter) var artrika och vanliga i de tidigpaleozoiska haven. Maskarnas käkar, benämda scolecodonter i den vetenskapliga litteraturen, är mycket vanliga mikrofossil i sedimentära bergarter, främst kalkstenar av denna ålder. Mycket pekar därför på att de ofta utgjorde en väsentlig del av bottenfaunan. Trots mångfalden av scolecodonter harJawed polychaete annelid worms were abundant and diverse in the early Palaeozoic seas and their jaws (scolecodonts) are common microfossils in sedimentary rocks of that age. Despite their abundance, relatively little work has been focused on these fossils. One reason for this is that their taxonomy has been, and to some extent still is, in a state of disorder, mainly because of a parataxonomic tre
In this report, numerical analyses of very narrow journal bearings are presented. The pressure distribution was determined for a number of different width-diameter ratios and eccentricities. For each combination, a number of relevant dimensionless design quantities were computed. The next step was to obtain curve-fitted functions for the variation in each design quantity. The functions are intende
