Current research on Parkinson's disease (PD) pathogenesis requires relevant animal models that mimic the gradual and progressive development of neuronal dysfunction and degeneration that characterizes the disease. Polymorphisms in engrailed 1 (En1), a homeobox transcription factor that is crucial for both the development and survival of mesencephalic dopaminergic neurons, are associated with spora

To establish the occurrence, modulation and functional significance of compound exocytosis in insulin-secreting beta cells. Exocytosis was monitored in rat beta cells by electrophysiological, biochemical and optical methods. The functional assays were complemented by three-dimensional reconstruction of confocal imaging, transmission and block face scanning electron microscopy to obtain ultrastruct

Background: Reported improvements in outcome in stroke patients treated in hospital are often attributed to advances in stroke care. However, secular trends in patient characteristics that are present already on admission to hospital may also contribute to improved outcome. Methods: Time trends for baseline data (289,854 stroke admittances) in Riks-Stroke, the Swedish national quality register for

Bacterial Protein A (PrtA) and Protein G (PrtG) are widely used for affinity purification of antibodies. An understanding of how PrtA and PrtG bind to different isotypes of immunoglobulin type G (IgG) and to their corresponding Fc fragments is essential for the development of PrtA and PrtG mimetic ligands and for the establishment of generic processes for the purification of various antibodies. In

This review aims to sum up current knowledge on the sensitivity and specificity of ultrasound features suggestive of acute pelvic inflammatory disease (PID).

OBJECTIVE: To compare the neonatal outcome after a trial of labor (TOL) with that after an elective cesarean section (CS) following one previous cesarean delivery, considering the indication for the first CS. DESIGN: Population-based cohort study. SETTING: Sweden. POPULATION: Women with their first two deliveries 1992-2007 registered in the Swedish Medical Birth Registry. METHODS: The risk of low

Clubhouses are supposed to follow the International Clubhouse Standards, but they also need to make adaptations according to national and local contexts. This article compares the implementation of peer support elements in the clubhouse model in two different social contexts: the Swedish and the Japanese welfare systems. Participatory observations and interviews with members and staff at a Swedish

Sparse sums of Lorentzians can give good approximations to functions consisting of linear combination of piecewise continuous functions. To each Lorentzian, two parameters are assigned: translation and scale. These parameters can be found by using a method for complex frequency detection in the frequency domain. This method is based on an alternating projection scheme between Hankel matrices and f

This paper analyses the credibility of author anonymity that is provided by a double-blind review process. It is argued that authors have strong incentives to disseminate information about their papers before publication. A sample from two economics journals, both using double-blind review processes, provides evidence that author-revealing information of most accepted papers is available on the In

Many biting midges of the genus CulicoidesLatreille, 1809 (Diptera: Ceratopogonidae) are competent vectors of a diverse number of pathogens. The identification of their feeding behaviour and of vector-host associations is essential for understanding their transmission capacity. By applying two different nested polymerase chain reaction (PCR) assays, of which one targeted the avian cyt b gene and t

The current epidemiologic evidence suggests that men with type 2 diabetes mellitus may be at lower risk of developing prostate cancer, but little is known about its association with stage and grade of the disease. The association between self-reported diabetes mellitus at recruitment and risk of prostate cancer was examined in the European Prospective Investigation into Cancer and Nutrition (EPIC)

The solution behaviour of b-glucans in a gastrointestinal model was investigated in order to explore the mechanisms explaining the physiological effects of the soluble fibre. Asymmetrical flow field-flow fractionation was used to determine the molar mass distribution, and in-line calcofluor labelling allowed specific detection of b-glucans in complex samples. When dispersed in water, weight-averag

Background: A blunted growth hormone and prolactin response to pharmacological stress test have previously been found in depressed patients, as well as an increased cortisol response to psychosocial stress. This study investigated these hormones in response to acute exercise using an incremental bicycle test. Method: A cross-sectional comparison of cortisol, growth hormone, and prolactin in depres

Objective: The objective of this study was to investigate quality of life (QoL) in patients with Graves' disease treated with radioiodine or antithyroid drugs. Design and methods: The design of the study consists of an open, prospective, randomized multicenter trial between radioiodine and medical treatment. A total of 308 patients were included in the study group: 145 patients in the medical grou

Neurog3 is expressed transiently in pancreatic endocrine progenitors where it is responsible for activating a transcription factor cascade which eventually defines the mature endocrine cells. However, the mechanism by which Neurog3 regulates different aspects of the endocrine differentiation program is less clear. In this report we used in ovo electroporation to investigate how manipulation of Neu

Abstract in UndeterminedThis short communication presents a general overview of facts concerning wh-extraction from V2 clauses in the Scandinavian languages. While extraction from V2 clauses with a fronted non-subject is impossible in all of these languages, three classes can be distinguished with regard to extraction from subject-initial V2 clauses.

How hard are geometric vision problems with outliers? We show that for most fitting problems, a solution that minimizes the num- ber of outliers can be found with an algorithm that has polynomial time- complexity in the number of points (independent of the rate of outliers). Further, and perhaps more interestingly, other cost functions such as the truncated L2 -norm can also be handled within the

During the last 20 years a tremendous improvement in the care of patients with pituitary tumors and of hypopituitarism has been achieved. If we resolve most of the possible causes of the increased cardiovascular disease and stroke mortality a normal survival is expected in these patients. Recently, a large population based study showed a decline in the risk of non-fatal stroke and of non-fatal car

Malmo and Uppsala have been regional centres for the treatment of cleft lip and palate since the beginning of the 1950s. We have about 80 new cases every year and most patients have conventional oronasal clefts, either cleft lip and palate or isolated cleft palate. During a 10-year period we have come across four patients who have had varying degrees of midface dysplasia combined with intracranial

Attenuation-based tomosynthesis has proven to successfully resolve the glandular tissue overlap present in mammography. However, the ability of tomosynthesis to differentiate tumorous and glandular tissue remains limited, due to the small differences in X-ray attenuation in breast tissue. One possibility to overcome this limitation and to further increase the diagnostic value of tomosynthesis exam