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Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy

Objectives There is an epidemic of Mesoamerican nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case-control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN was conducted with the aim of char

Coping strategies among patients with malignant lymphoma– a qualitative study from the perspectives of Swedish patients

PURPOSE: There is a dearth of research on coping strategies of patients with malignant lymphoma. The aim of this article is to explore how these patients cope with cancer in everyday life.METHOD: Semi-structured interviews were conducted with nine patients in Sweden. A thematic analysis was made, inspired by Antonovsky’s theory of sense of coherence. The SRQR checklist was used. RESULTS: Patient’sPurposeThere is a dearth of research on coping strategies of patients with malignant lymphoma. The aim of this article is to explore how these patients cope with cancer in everyday life.MethodSemi-structured interviews were conducted with nine patients in Sweden. A thematic analysis was made, inspired by Antonovsky's theory of sense of coherence. The SRQR checklist was used.ResultsPatient's coping

Railway network design and regional labour markets in Sweden

Investment in railways, and transport infrastructure in general, are often motivated because they are believed to improve peoples’ accessibility to jobs. By linking together and increasing the size of labour markets, the matching between individuals and jobs is improved, and the productivity increases. Communities and municipalities lobby for investments that lead to higher accessibility and those

Age-resolved chemistry of red giants in the solar neighbourhood

In the age of high-resolution spectroscopic stellar surveys of the Milky Way, the number of stars with detailed abundances of multiple elements is rapidly increasing. These elemental abundances are directly influenced by the evolutionary history of the Galaxy, but this can be difficult to interpret without an absolute timeline of the abundance enrichment. We present age-abundance trends for [M/H],

Determining Ages of APOGEE Giants with Known Distances

We present a sample of 705 local giant stars observed using the New Mexico State University 1 m telescope with the Sloan Digital Sky Survey-III/Apache Point Observatory Galactic Evolution Experiment (APOGEE) spectrograph, for which we estimate stellar ages and the local star formation history (SFH). The high-resolution (R ̃ 22,500), near infrared (1.51-1.7 μm) APOGEE spectra provide measurements o

Selective Cytotoxicity of Damsin Derivatives in Breast Cancer Cells

Cancer is the leading cause of death worldwide, and there is a constant need for new treatmentstrategies. Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways.

Evidence of climate shift for temperature and precipitation extremes across Gansu Province in China

Temperature and precipitation extremes are the dominant causes of natural disasters. In this study, seven indices of extreme temperature and precipitation events in Gansu Province, China, were analysed for the period 1961–2017. An abrupt climate shift was recorded during 1980–1981. Thus, the study period was divided into a preshift (before the climate shift) period 1961–1980 and an aftshift (after

Activism and participation among people of migrant background : discourses and practices of inclusiveness in four italian cities

As interest in the processes of integration of immigrants and ethnic minorities grows among European scholars, the role of multiple actors in shaping civic and political participation by people of migrant background needs to be further examined. Building on the literature on migration, this study addresses the following research question: What accounts for differences in forms of civic and politic

Interactions between extreme climate and urban morphology : Investigating the evolution of extreme wind speeds from mesoscale to microscale

This paper investigates the interactions between urban morphology indicators and extreme weather variables. In this regard, variations of wind speed and air temperature at the urban microscale are studied for three urban morphologies by means of numerical simulations. Each urban model contains ninety-nine calculation points at different locations and heights to assess the variations during two 24-

Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1/rhIGFBP-3 in extremely preterm infants

Objective: Steady state insulin-like growth factor-1 (IGF-1) levels vary significantly during continuous intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1/rhIGFBP-3) in the first weeks of life in extremely preterm infants. We evaluated interleukin-6 (IL-6) and insulin-like growth factor binding protein-1 (

Measuring the effects of energy transition : A structural decomposition analysis of the change in renewable energy use between 2000 and 2014

This study investigates the growth in global renewable energy use between 2000 and 2014. To identify its main contributors and their geographical distribution, a structural decomposition analysis is applied to global multi-regional input-output tables. A new variant of this type of analysis is developed that introduces energy transition (i.e. the substitution of non-renewable energy by renewable e

Rural supply chain management: a multidimensional framework for future research in Europe

Innovations affect urban and rural areas differently. Although thesupply chain management (SCM) literature recognises the interaction betweenurban and rural areas in terms of flow of products, people and communication,the rural perspective is clearly missing. An inductive approach was appliedusing an interdisciplinary panel of international experts to explore challengesand opportunities in the int

Functional Screening Identifies MicroRNA Regulators of Corin Activity and Atrial Natriuretic Peptide Biogenesis

Atrial natriuretic peptide (ANP) represents an attractive therapeutic target in hypertension and heart failure. The biologically active form of ANP is produced by the cardiac serine protease corin, and modulation of its activity might therefore represent a novel approach for ANP augmentation. MicroRNAs (miRNAs) are pervasive regulators of gene expression, but their potential role in regulating cor

Progression in Glaucoma

The treatment of glaucoma is focused on reducing the intraocular pressure to a level at which progression is impeded. A diagnosis of glaucoma is not considered certain until progression is confirmed, and thus detecting progression is a central aspect in both the diagnosing and the monitoring of glaucoma patients. Progression can be identified either through examination of either functional changes