The use of mono-crystalline silicon microstructures for high-speed and high sensitivity protein mapping and protein identification is presented as an important contribution within the field of proteomics. The various approaches for handling minute amounts of protein sample are described. Piezoelectric dispensing units developed in-house are being used for sample-handling and the generation of 60-p

We used a simple discrete-time population model to investigate how temporally structured density-dependence influences a population's response to loss due to harvesting. We assumed that reproduction is a relative discrete event in time, followed by density-dependent mortality and then harvesting, or followed by harvesting and then density-dependent mortality. Such an ordering of events in time may

I denna rapport redovisas teoretiska beräkningar av energibehov till uppvärmning, tappvarmvatten och hushållselektricitet, energitransporter genom småhusens grunder och energiflöden genom köldbryggor. Beräkningarna omfattar 26 småhus på Bo 92 i Örebro med olika typer av grundläggning, värmeisolering, fönster, värme- och ventilationssystem. Beräkningarna har utförts med datorprogrammen ENORM, CRAWL

Vanadate and peroxovanadate (pV), potent inhibitors of tyrosine phosphatases, mimic several of the metabolic actions of insulin. Here we compare the mechanisms for the anti-lipolytic action of insulin, vanadate and pV in rat adipocytes. Vanadate (5 mM) and pV (0.01 mM) inhibited lipolysis induced by 0.01-1 microM isoprenaline, vanadate being more and pV less efficient than insulin (1 nM). A loss o

The sound values of /z/ and /r/ in proto-Nordic are discussed. It is suggested that the modern Swedish [r] and [R] are different results in different areas of the merger between /z/ and /r/ in Old Swedish, depending on the distribution of stress in polysyllabic words. The article is a shorter version of Teleman, U. (2005), Om r-fonemets historia i Svenskan (Nordlund 5). Insittutionen för nordiska

Vascular smooth muscle cells (VSMCs) in the intact vascular wall are differentiated for contraction, whereas the response to vascular injury involves transition towards a synthetic phenotype, with increased tendency for proliferation. Platelet-derived growth factor (PDGF) is thought to be important for this process. We investigated expression and functional coupling of PDGF receptors (PDGFRs) alph

Status of three natural groups of xanthorioid lichens (Teloschistaceae), namely Xanthomendoza ulophyllodes, Xanthoria elegans and Teloschistes villosus groups is revised. Their status is elevated to the generic level. They are segregated from other hitherto accepted groups, namely Oxneria (with type species Oxneria alfredii (S. Kondr. & Poelt) S. Kondratyuk & Karnefelt) from Xanthomendoza,

Superdeformation, i.e. elongated shapes with the longest axis approximately twice as long as the shorter axes, has provided many new insights in nuclear structure. In this dissertation the possibility of forming superdeformed states related to two connected spheres, having a more or less pronounced neck, is investigated. Detailed Nilsson-Strutinsky calculations with the cranked Woods-Saxon potenti

In order to identify biological processes relevant for cell death and survival in the brain following stroke, the postischemic brain transcriptome was studied by a large-scale cDNA array analysis of three peri-infarct brain regions at eight time points during the first 24 h of reperfusion following middle cerebral artery occlusion in the rat. K-means cluster analysis revealed two distinct biphasic

The role of the DEK protein, involved in the leukemia-associated fusion protein DEK-CAN, is not yet known. In this study, we show a higher expression of DEK mRNA in immature cells than in mature cells. Furthermore, a correlation between DEK expression and cell proliferation was demonstrated, suggesting that DEK plays a role in the proliferation of hematopoietic cells and raising the question of wh

The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our under

We demonstrate how to generalize two of the most well-known random graph models, the classic random graph, and random graphs with a given degree distribution, by the introduction of hidden variables in the form of extra degrees of freedom, color, applied to vertices or stubs (half-edges). The color is assumed unobservable, but is allowed to affect edge probabilities. This serves as a convenient me

Endo-beta-1,4-D-mannanase is the key depolymerizing enzyme for beta-1,4-mannan polymers present in the cell walls of plants and some algae, as well as in some types of plant seeds. Endo-1,4-beta-mannanase from blue mussel Mytilus edulis (MeMan5A) belongs to the glycoside hydrolase (GH) family 5 enzymes. The MeMan5A structure has been determined to 1.6 angstrom resolution using the multiple-wavelen

There are several ways to implement and work with the Balanced Scorecard (BSC). The company Ericsson Data AB was one of the pioneers in employing the BSC in Sweden. As early adopters, they were interested in obtaining an evaluation performed by external researchers. We were fortunate to have that opportunity. During the autumn of 1998, Majvor Karlsson and Ellen Sharma had full access to the develo