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Kinetic Studies of Amino Acid-Based Surfactant Binding to DNA

In this work, the binding kinetics of amino acid-based surfactants, presenting different linkers and head groups, with calf thymus (CT)-DNA was studied using stopped-flow fluorescence spectroscopy. The kinetic studies were carried out as a function of Na+ concentration and surfactant-to-DNA charge ratio. The surfactant binding on DNA took place in two consecutive steps, for which the corresponding

Varying Virtue : Mythological Paragons of Wifely Virtues in Roman Elegy

This dissertation investigates references to five mythological characters (Penelope, Laodamia, Andromache, Alcestis and Euadne) used as paragons of wifely virtues in Roman elegy. Providing extensive close readings, it discusses the usage of these five characters in the works of Propertius and Tibullus, and in the elegiac works of Ovid, with special reference to issues of narratology, intertextuali

Global Cambrian trilobite palaeobiogeography assessed using parsimony analysis of endemicity

Palaeobiogeographical data on Cambrian trilobites obtained during the twentieth century are combined in this paper to evaluate palaeoceanographic links through c. 30 myr, once these arthropods biomineralized. Worldwide major tectonostratigraphic units are characterized at series intervals of Cambrian time and datasets of trilobite genera (629 for Cambrian Series 2, 965 for Cambrian Series 3, and 8

Coherence as a heuristic

The impossibility results of Bovens and Hartmann (2003) and Olsson (2005) call into question the strength of the connection between coherence and truth. As part of the inquiry into this alleged link, I define a notion of degree of truth-conduciveness, relevant for measuring the usefulness of coherence measures as rules-of-thumb for assigning probabilities in situations of partial knowledge. I use

Temperature-Corrected Oxygen Detection Based on Multi-Mode Diode Laser Correlation Spectroscopy

Temperature-corrected oxygen measurements were performed by using multi-mode diode laser correlation spectroscopy at temperatures ranging between 300 and 473 K. The experiments simulate in situ monitoring of oxygen in coal-combustion exhaust gases at the tail of the flue. A linear relationship with a correlation coefficient of -0.999 was found between the evaluated concentration and the gas temper

Synthesis of amorphous Mg(BH4)(2) from MgB2 and H-2 at room temperature

Due to its high hydrogen content and its favourable overall thermodynamics magnesium tetrahydroborate has been considered interesting for hydrogen storage applications. In this work we show that unsolvated amorphous magnesium tetrahydroborate can be obtained by reactive ball milling of commercial MgB2 under 100 bar hydrogen atmosphere. The material was characterized by solid-state NMR which showed

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database.

The clinical classification of hereditary sequence variants identified in disease-related genes directly affects clinical management of patients and their relatives. The International Society for Gastrointestinal Hereditary Tumours (InSiGHT) undertook a collaborative effort to develop, test and apply a standardized classification scheme to constitutional variants in the Lynch syndrome-associated g

Catalytic dehydrogenation of cyclooctane and triethylamine using aliphatic iridium pincer complexes

The majority of the known pincer iridium based catalysts for dehydrogenation of alkanes has arene-based backbones. Here, the catalytic activity of aliphatic iridium pincer complexes, viz, the cyclohexane-based phosphine complex (PCyP)IrHCl (4) (PCyP = {cis-1,3-bis-[(di-tert-butylphosphino)methyl]cyclohexane}(-)) and the 2-methylpropane-based phosphinite complex (POCOP)IrHCl (5) (POCOP = 1,3-bis-(d

Aspects of T cell development contributing to autoimmunity.

Popular Abstract in Swedish Autoimmuna sjukdomar, såsom typ 1 diabetes, uppstår till följd av en obalans i immunsystemet där immunceller ser kroppens egna vävnader som ett hot och angriper dem. Vid typ 1 diabetes är det de insulin-producerande β-cellerna i bukspottskörteln som förstörs, vilket leder till att man resten av livet får tillföra kroppen insulin genom injektioner. Anledningen till varföAutoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. The work presented in this thesis was aiming at unravelling some of those aspects. We have investi

Search for the associated production of the Higgs boson with a top quark pair in multilepton final states with the ATLAS detector

A search for the associated production of the Higgs boson with a top quark pair is performed in multilepton final states using 20.3 fb(-1) of proton-proton collision data recorded by the ATLAS experiment at root s = 8 TeVat the Large Hadron Collider. Five final states, targeting the decays H -> WW*, tau tau, and ZZ*, are examined for the presence of the Standard Model (SM) Higgs boson: two same-ch

Performance and wear mechanisms of whisker-reinforced alumina, coated and uncoated PCBN tools when high-speed turning aged Inconel 718

Abstract in UndeterminedInconel 718, an efficient superalloy for energy and aerospace applications, is currently machined with cemented carbide tools at low speed (vc≈60 m/min) due to its unfavorable mechanical and thermal properties. The article presents results of a study of superalloy machinability with whisker reinforced alumina, uncoated and coated PCBN tools. Turning of age hardened Inconel

Design of a Web-based individual coping and alcohol-intervention program (web-ICAIP) for children of parents with alcohol problems: study protocol for a randomized controlled trial

Background: It has been estimated that approximately 20% of all Swedish children grow up with parents having alcohol problems, which may result in negative outcomes among these children. Therefore, most Swedish municipalities provide resources for support, but at the same time figures reveal that not even 2% receive support, mainly due to difficulties in identifying and recruiting these children i

Preparation and characterization of nanometer-thin freestanding polymer foils for laser-ion acceleration

We report on the production and characterization of polymer-based ultra-thin (sub 10 nm) foils suited for experiments on laser-ion acceleration in the regime of radiation pressure acceleration. Beside the remarkable mechanical stability compared with commonly used diamond-like-carbon foils, a very homogeneous layer thickness and a small surface roughness have been achieved. We describe the technic

Towards an understanding of fatigue in Parkinson's disease.

OBJECTIVES: To gain an improved understanding of fatigue in Parkinson's disease (PD) by exploring possible predictors among a wide range of motor and non-motor aspects of PD. METHODS: 118 consecutive PD patients (54% men; mean age, 64 years) were assessed regarding fatigue, demographics and a range of non-motor and motor symptoms. Variables significantly associated with fatigue scores in bivariate

Search for one large extra dimension with the DELPHI detector at LEP

Single photons detected by the DELPHI experiment at LEP2 in the years 1997-2000 are reanalysed to investigate the existence of a single extra dimension in a modified ADD scenario with slightly warped large extra dimensions. The data collected at centre-of-mass energies between 180 and 209 GeV for an integrated luminosity of similar to 650 pb(-1) agree with the predictions of the Standard Model and

Yu-Shiba-Rusinov states in phase-biased superconductor-quantum dot-superconductor junctions

We study the effects of a phase difference on Yu-Shiba-Rusinov (YSR) states in a spinful Coulomb-blockaded quantum dot contacted by a superconducting loop. In the limit where charging energy is larger than the superconducting gap, we determine the subgap excitation spectrum, the corresponding supercurrent, and the differential conductance as measured by a normal-metal tunnel probe. In absence of a