Melanoma is a highly metastatic cancer, and its incidence has increased over the past several decades. Angiogenesis is associated with melanoma metastasis and a poor prognosis. Many genetic and epigenetic factors affecting tumour vascularization and metastasis have been investigated, despite the heterogeneity of cancer cells and the complicated mechanisms involved in melanoma. Nemo-like kinase (NL

STUDY DESIGN: Retrospective study. OBJECTIVE: To describe surgical results in two and three dimensions and patient-reported outcomes of scoliosis treatment for Lenke type 1 idiopathic curves with an open anterior or posterior approach. SUMMARY OF BACKGROUND DATA: Different surgical techniques have been described to prevent curve progression and to restore spinal alignment in idiopathic scoliosis.

A few years ago, Alon et al. [ISMB 2008] gave a simple randomized O((2e)km∊−2)-time exponential-space algorithm to approximately compute the number of paths on k vertices in a graph G up to a multiplicative error of 1 ± ∊. Shortly afterwards, Alon and Gutner [IWPEC 2009, TALG 2010] gave a deterministic exponential-space algorithm with running time (2e)k+O(log3 k)m log n whenever ∊−1 = kO(1). Recen

Voices today from the eighties – constructing peaceful citizensThe increased interest for questions of survival, focused in the fear for a nuclear war, also became the start for university courses and of Action research both in public schools, in Teacher Education and in the Universities in Sweden. The article is arguing that there are roots back to the 1960s and a continuity within Peace Educatio

Production of cell-laden hydrogel droplets as miniaturized niches for 3D cell culture provides a new route for cell-based assays. Such production can be enabled by droplet microfluidics and here we present a droplet trapping system based on bulk acoustic waves for handling hydrogel droplets in a continuous flow format. The droplet trapping system consists of a glass capillary equipped with a small

We show that the permanent of an n × n matrix over any finite ring of r ≤ n elements can be computed with a deterministic 2n−Ω(nr ) time algorithm. This improves on a Las Vegas algorithm running in expected 2n−Ω(n/(r log r)) time, implicit in [Björklund, Husfeldt, and Lyckberg, IPL 2017]. For the permanent over the integers of a 0/1-matrix with exactly d ones per row and column, we provide a deter

We consider the problem of finding solutions to systems of polynomial equations over a finite field. Lokshtanov et al. [SODA'17] recently obtained the first worst-case algorithms that beat exhaustive search for this problem. In particular for degree-d equations modulo two in n variables, they gave an O∗2(1−1/(5d))n time algorithm, and for the special case d = 2 they gave an O∗20.876n time algorith

Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of motor behaviors and have also been implicated in the processing of motivational content and in higher cognitive functions. During the last two decades, electrophysiological recordings in basal ganglia circuits have shown that several disease conditions are associated with specific changes in the tempo

AIMS: Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants an

Stars formed in clusters can encounter other stars at close distances. In typical open clusters in the Solar neighbourhood containing hundreds or thousands of member stars, 10-20 per cent of Solar-mass member stars are expected to encounter another star at distances closer than 100 au. These close encounters strongly perturb the planetary systems, directly causing ejection of planets or their capt

BACKGROUND: EndoVAC hybrid therapy for infected femoral artery reconstructions consists of endovascular relining with a stent graft, surgical debridement and vacuum-assisted wound closure (VAC), and may be considered as a bailout procedure. The aim of this study was to analyze differences in risk factors of patients receiving EndoVAC compared to standard VAC therapy for perivascular infected femor

Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.

Aim: To investigate the prevalence of general and back pain in children with cerebral palsy and the relationships between scoliosis and back pain. Methods: Cross-sectional register study based on data from the Swedish Cerebral Palsy Follow-Up Programme. Descriptive analyses and logistic regression to regress age, sex, gross motor function, windswept, hip extension and source of report on the prese