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We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10-7); of these, 16 map outside known risk-associated loci. We make two important observations. First, only five of these signals are driven by low-frequency variants: even for these, effect sizes are modest (odds ratio ≤1.29). Se

Drainage networks are the basis for segmentation of watersheds, an essential component in hydrological modelling, biogeochemical applications, and resource management plans. With the rapidly increasing availability of topographic information as digital elevation models (DEMs), there have been many studies on DEM-based drainage network extraction algorithms. Most of traditional drainage network ext

BACKGROUND: Pre-treatment with unfractionated heparin is common in ST-segment elevation myocardial infarction (STEMI) protocols, but the effect on intracoronary thrombus burden is unknown. We studied the effect of heparin pre-treatment on intracoronary thrombus burden and Thrombolysis in Myocardial Infarction (TIMI) flow prior to percutaneous coronary intervention in patients with STEMI.METHODS: T

Cardiovascular and inflammatory biomarkers in therapeutic hypothermia have been studied in cardiac arrest, but data on patients with ST-segment elevation myocardial infarction (STEMI) treated with therapeutic hypothermia are currently unavailable. A multiplex proximity extension assay allowed us to measure 157 cardiovascular disease (CVD) and inflammatory disease-related biomarkers in patients fro

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitat

Fano interferences in nanostructures are influenced by dissipation effects as well as many-body interactions. Two-dimensional coherent spectroscopies have just begun to be applied to these systems where the spectroscopic signatures of a discrete-continuum structure are not known. In this article, we calculate the excited-state absorption contribution for different models of higher lying excited st

Background: Abdominal obesity is linked to cardiovascular diseases in type 1 diabetes (T1D). The primary aim was to explore associations between abdominal obesity and cardiovascular complications, metabolic and inflammatory factors. The secondary aim was to explore whether achieved recommended treatment targets differed between the obese and non-obese participants. Methods: Cross sectional study o

Background: Physical activity is one of the best documented activities with impacts on health in children and adults. Children born preterm show reduced physical and psychosocial function compared to children born at term. This may influence their level of physical activity. Reports on moderately preterm children's physical activities during childhood are limited. Thus, the aim of this study was t

Aims: Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here, we aimed to establish if SLEs reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D) using data from the prospective Diabetes Prediction in Skåne (DiPiS) study. Methods: Prospective questionnaire data recorded at 2 months (n = 23,187) and 2 years of age (n

Labour market integration, and the free movement of people, has been a key feature of the European Economic Area (EEA). In fact, the EEA states that the free movement of people is “perhaps the most important right for individuals, as it gives citizens of the 31 EEA countries the opportunity to live, work, establish business and study in any of these countries.” However, unless citizens within the

The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial serum metabolites and lipid species. In a randomized controlled trial with crossover design, healthy adults (n = 20) underwent a 4-week intervention with two balanced diets that va

Modern devices often include several embedded instruments, such as BIST interfaces, sensors, calibration facilities. New standards, such as IEEE Std 1687, provide vehicles to access these instruments. In approaches based on reconfigurable scan networks (RSNs), instruments are coupled with scan registers, connected into chains and interleaved with reconfigurable modules. Such modules embed reconfig

This article examines the narrative and discursive feminist labor of the Swedish 2010 Twitter-initiated #talkaboutit campaign focusing on sexual “gray areas.” The campaign sought to lessen the perceived gap between experience and discourse and work towards an adequate language encompassing difficult sexual situations presented as residing in the gray area between choice and coercion. Autobiographi

Background: Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposited in the respiratory tract. Knowledge of the underlying mechanisms behind observed symptoms is still partly lacking, although inflammation is suggested to play a central role. Th

Background: The range of onset ages within some PSEN1 families is wide, and a few cases of reduced penetrance of PSEN1 mutations have been reported. However, published data on reduced penetrance have been limited to clinical histories, often collected retrospectively and lacking biomarker information. We present a case of reduced penetrance of the PSEN1 H163Y mutation in a carrier prospectively fo

The centrality dependence of the mean charged-particle multiplicity as a function of pseudorapidity is measured in approximately 1 (Formula presented.) b (Formula presented.) of proton–lead collisions at a nucleon–nucleon centre-of-mass energy of (Formula presented.) (Formula presented.) using the ATLAS detector at the Large Hadron Collider. Charged particles with absolute pseudorapidity less than

Exploratory testing (ET) is a powerful and efficient way of testing software by integrating design, execution, and analysis of tests during a testing session. ET is often contrasted with scripted testing, and seen as a choice of either exploratory testing or not. In contrast, we pose that exploratory testing can be of varying degrees of exploration from fully exploratory to fully scripted. In line

Structural change, economic diversification and new path development feature prominently in scientific and policy debates. Against the backdrop of increasing specialization in the economy, this paper reinterprets Schumpeterian innovative entrepreneurship as a fundamental process that creates new connections between distinct fields of specialization, thereby induces path-breaking innovations and st

Environmental stresses, including ammonium (NH4 +) nourishment, can damage key mitochondrial components through the production of surplus reactive oxygen species (ROS) in the mitochondrial electron transport chain. However, alternative electron pathways are significant for efficient reductant dissipation in mitochondria during ammonium nutrition. The aim of this study was to define the role of ext

Objective: The aim of this investigation was to study differences between male and female patients with stage T1 urinary bladder cancer (UBC) regarding intravesical instillation therapy, second resection and survival. Materials and methods: This study included all patients with non-metastatic primary T1 UBC reported to the Swedish National Register of Urinary Bladder Cancer (SNRUBC) from 1997 to 2