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Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation, a potentially curative therapy for hematologic diseases. It has long been thought that murine bone marrow-derived T cells do not mediate severe GVHD because of their quantity and/or phenotype. During the course of experiments testing the impact of housing temperatures on GVHD, we discovered

Granzyme B (GzmB) has previously been shown to be critical for CD8(+) T cell-mediated graft-versus-host disease (GVHD) but dispensable for GVHD mediated by CD4(+) T cells. However, previous studies used high doses of CD4(+) T cells in MHC-mismatched models that caused rapid and lethal GVHD. Because of the hyperacute lethality, it is possible that the role of GzmB was concealed by the system. There

Traditional treatments, including a variety of thermal therapies have been known since ancient times to provide relief from rheumatoid arthritis (RA) symptoms. However, a general absence of information on how heating affects molecular or immunological targets relevant to RA has limited heat treatment (HT) to the category of treatments known as "alternative therapies". In this study, we evaluated t

Toll-like receptor (TLR) mediated recognition of pathogen associated molecular patterns allows the immune system to rapidly respond to a pathogenic insult. The "danger context" elicited by TLR agonists allows an initially non-immunogenic antigen to become immunogenic. This ability to alter environment is highly relevant in tumor immunity, since it is inherently difficult for the immune system to r

Allogeneic hematopoietic cell transplantation is an established treatment for hematologic and other malignancies. Donor-derived immune cells can identify and attack host tumor cells, producing a graft-versus-tumor (GVT) effect that is crucial to the treatment. Using multiple tumor models and diverse donor-host combinations, we have studied the role of granzyme B (GzmB) in GVT effect. We first conf

Allogeneic hematopoietic cell transplantation is an established treatment for hematologic and nonhematologic malignancies. Donor-derived immune cells can identify and attack host tumor cells, producing a graft-versus-tumor (GVT) effect that is crucial to the effectiveness of the transplantation therapy. CBLB502 is a novel agonist for TLR5 derived from Salmonella flagellin. On the basis of TLR5-med

The article explores the relationship between emotions, collective identity and mobilisation in conservative social movements through an analysis of the World Congress of Families’ (WCF) 13th international conference, held in Verona in March 2019. WCF promotes Christian family values and brings together anti-gay, anti-feminist and anti-abortion activists, religious leaders, and politicians from ar

This article explores the paradox of corporations using social and environmental justice concerns to market products that are themselves made in conditions of environmental and social injustice, most often in the Global South. The effects of the fashion industry on people is two-pronged: 1) the unsafe and exploitative conditions under which many garment workers operate, and 2) the severe and harmf

Computational methods gained a widespread use in drug discovery. Understanding conformational dynamics of protein and mechanisms of protein-ligand binding are two major areas in drug discovery. Molecular dynamics (MD) simulation have been routinely used to study conformational dynamics of protein and mechanisms of protein-ligand binding. In classical MD simulation, the system often remains stuck i

Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P < 5 × 10-8) loci with 68 independent single nucleotide polymorphisms. Analysis of risk estimates across geographical regions and host factors suggests the acral melanoma sub

BACKGROUND: Tremor is a cardinal symptom of Parkinson's disease (PD) that may cause severe disability. As such, objective methods to determine the exact characteristics of the tremor may improve the evaluation of therapy. This methodology study aims to validate the utility of two objective technical methods of recording Parkinsonian tremor and evaluate their ability to determine the effects of Dee

The presence of paralytic shellfish poisoning toxins (PSTs) in drinking water resources has urged the development of simple and fast screening tools for drinking water surveillance. This article aims to validatea quick test kit for freshwater PSTs detection. Preliminary estimates of the limit of detection (LODs)were done for 5 PSPs variants, namely C1 toxin (a “C” toxin); GTX5(a Gonyautoxin); and

This article investigates how regulation related to maintaining state registration and tax beneficial status affects professionalisation, covering paid staff and volunteers with specialist skills, of political parties, advocacy groups and service providing organisations. The article fills a gap in the literature which until now has been mainly concerned with the influence of state funding on profe

The paper discusses the underlying characteristics of Macedonian illiberal politics during the 11-year rule of the centre-right party VMRO-DPMNE (2006–2017) focusing on two aspects: institutional and symbolic. We argue that the unfair political competition was enabled by the weakness of pre-existing institutions and the population’s clientelist preferences, which were systematically exploited and