Sepsis is one of leading cause of death despite aggressive surgical intervention and antibiotic therapies. Excessive neutrophil recruitment is a major feature in early phase with immune system dysfunction at later phase. Lung is the most vulnerable, critical and sensitive organ during sepsis process. The aim of thesis was to prevent excessive neutrophil accumulation in lung parenchyma on one hand,

A neutron transport system for the planned imaging instrument ODIN at the future European Spallation Source (ESS) based on neutron optical components was designed and optimized. Different ways of prompt pulse suppression were studied. The spectral performance of the optimal neutron guide configuration is presented. In addition, the influence of the gaps in the guide system needed for the required

The aim of this study was to ascertain whether there is a relationship between plant species richness and plant-available N, P and water in an environment subject to little anthropogenic disturbance. To accomplish this we studied the vegetation in matorral shrub-lands in northern Patagonia, Argentina. Due to the variation in slope, precipitation and aspect between the sites water status was determ

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia that presents early in infancy. The main hematopoietic symptoms include macrocytic anemia with reticulocytopenia and selective absence of erythroid precursors in a normocellular bone marrow. In addition to the hematopoietic symptoms, DBA is characterized by the presence of physical abnormalities and cancer predisposition. Mutations

Monitoring and evaluation of malaria control in pregnancy is essential for assessing the efficacy and effectiveness of health interventions aimed at reducing the major burden of this disease on women living in endemic areas. Yet there is no currently integrated strategic approach on how this should be achieved. Malaria control in pregnancy is formulated in relation to epidemiological patterns of e

A method of separately quantifying organic and inorganic 14C compounds present in spent ion-exchange resins and process water from nuclear power reactors has been developed. Extraction of carbon compounds is accomplished by means of acid stripping (inorganic 14C) and subsequent wet oxidation (organic 14C) or by N2 purging in combination with a catalytic furnace (oxidized and reduced gaseous compou

Antalet cirkulationsplatser fortsätter att öka. Personer med synskada uppger att det är svårt för dem att korsa gatan vid cirkulationsplatser och det finns idag inte tillräckligt med kunskap för att lösa tillgänglighetsproblemen. Den forskning som finns idag studerar enbart blinda personer, trots att den stora majoriteten synskadade har synrester. Syftet med denna studie var att fastställa hur cirAntalet cirkulationsplatser fortsätter att öka. Personer med synskada uppger att det är svårt för dem att korsa gatan vid cirkulationsplatser och det finns idag inte tillräckligt med kunskap för att lösa tillgänglighetsproblemen. Den forskning som finns idag studerar enbart blinda personer, trots att den stora majoriteten synskadade har synrester. Syftet med denna studie var att fastställa hur cir

A phase-field based topology optimization approach is considered for the maximum stiffness or minimum compliance problem. The objective functional to be minimized consists in addition to the compliance a cost for gray solutions and a cost for interfaces between void and full material. Since the interfaces between void and full material are penalized via a volume integral in the original phase-fiel

The exchange of persistent organic pollutants (POPS) between different compartments of a typical mature boreal forest was investigated. The study focused on fluxes of polychlorinated biphenyls (PCBs) between the atmosphere, vegetation and soil, and within the soil to assess whether this type of forest acts as a final sink-or temporary repository for POPs. The study, at a Swedish site, suggested to

Screening mammography plays a key role in the early detection of breast cancer, however, estimates of sensitivities (48-88%) and specificities (82-98%) suggest that the diagnostic accuracy can be improved (1, 2, 3). Breast tomosynthesis (BT) is a 3D technique that is expected to improve breast cancer detection compared to screen-film and digital mammography DM). This work presents two clinical obs

Väl fungerande bytespunkter är viktiga för kollektivtrafikens konkurrenskraft. Själva bytet, som är en del av varje resa, kan upplevas som en stor del av reskedjan, varför det är viktigt att bytestiden minimeras men även att bytespunkten erbjuder så hög komfort- och servicenivå som möjligt. Grunden för projektet är konstaterandet att våra kunskaper är bristfälliga när det gäller hur viktig bytespu

Popular Abstract in Swedish Det övergripande syftet med denna avhandling är att visa hur elever i sina bilder berättar om hur det är att vara elev i skolan idag, och att visa reflektioner och samtal som bilderna ger upphov till hos lärare och lärarstudenter. En utgångspunkt har varit att bilder bär på kunskap, mening och betydelse som inte alltid kommer fram i det talade och skrivna språket. AvhanThe overall aim of this thesis is to examine how pupils in their pictures depict what it means to be a pupil in school today, and to explore the reflections and discussions that the images give rise to among teachers and student teachers. A starting point is the assumption that images are carriers of aspects of knowledge, meaning and sense that cannot always be presented through spoken or written

Sustainability, resilience and safety are features of a society that are more affected by sound environments than is generally acknowledged, even if other environmental threats may appear more prominent. But when noise levels reach the limits of sustainability in society, it´s resilience to destructive processes of many kinds will be challenged. In an interdisciplinary symposium in 2014 arranged b

Several deep Greenland ice cores have been retrieved, however, capturing the Eemian period has been problematic due to stratigraphic disturbances in the ice. The new Greenland deep ice core from the NEEM site (77.45°N, 51.06°W, 2450 m.a.s.l) recovered a relatively complete Eemian record. Here we discuss the cosmogenic (10)Be isotope record from this core. The results show Eemian average (10)Be con

The study implements the Schumpeterian notion of creative reaction to articulate and test the hypothesis that the shift to the knowledge economy in advanced economies is the result of the creative reaction of firms, caught in out-of-equilibrium conditions by the fast globalization of product and factor markets since the last decade of the 20th century. Advanced countries specialized in the generat

Although the complement system, a pivotal component of innate immunty, is centrally involved in host defense against pathogens, its overactivation or deregulation may excessively amplify inflammation and contribute to immunopathology. Periodontitis, an oral infection-driven chronic inflammatory disease, has been linked with complement disruption by periodontal bacteria, resulting in inflammation a

The structure of charge-stabilized colloidal dispersions has been studied through a one-component model using a Yukawa potential with density-dependent parameters examined with integral equation theory and Monte Carlo simulations. Partial thermodynamic consistency was guaranteed by considering the osmotic pressure of the dispersion from the approximate mean-field renormalized jellium and Poisson-B