Genetic instrumental variable analysis: time to call mendelian randomization what it is. The example of alcohol and cardiovascular disease
Published 5 December 2019 In recent years, epidemiologists have increasingly sought to employ genetic data to identify ‘causal’ relationships between exposures of interest and various endpoints – an instrumental variable approach sometimes termed Mendelian randomization. However, this approach is subject to all of the limitations of instrumental variable analysis and to several limitations specifi