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Patients with frontotemporal dementia often lack the ability to empathize. A study at Lund University and Karolinska Institutet has now shown that these patients do not show the same brain activity as healthy individuals when they witness the pain of others, a finding that it is hoped will increase understanding of this specific dementia disease. This is an important piece of the puzzle now fallin

https://www.multipark.lu.se/article/new-study-shows-how-dementia-affects-brains-ability-empathise - 2025-12-07

A team of international researchers led by Professor Johan Jakobsson at Lund University has secured a 52 million SEK grant from the Aligning Science Across Parkinson’s (ASAP) initiative, in partnership with the Michael J Fox Foundation to investigate how mobile genetic elements —commonly referred to as "jumping genes"—contribute to neuroinflammation and the progression of Parkinson’s disease. Jump

https://www.multipark.lu.se/article/52-million-sek-goes-uncovering-genetic-drivers-parkinsons-disease - 2025-12-07

Dear colleagues and collaborators,As we approach the end of 2024, I believe that we can look back with pride on the many things that we have achieved together this year. We would like to thank all of you for your vital contributions to our research environment, encompassing diverse roles and capacities. Next year is poised to be a particularly eventful year for MultiPark. On December 12, the Swedi

https://www.multipark.lu.se/article/seasons-greetings-multipark - 2025-12-07

Dear colleagues and collaborators,Welcome to a new year with MultiPark!Our Management group has now resumed its activities at full pace, and we are happy to share some fresh information as follows:(i) The dates for this year´s meetings of the MultiPark Board and Steering group have been set and posted under this link https://www.multipark.lu.se/about-multipark/management. We welcome Oxana Klementi

https://www.multipark.lu.se/article/kicking-year-packed-program-ahead - 2025-12-07

Don't miss the latest episode of MultiPark's podcast Meet our scientists. MultiPark's newest research group leader, Henrik Ahlenius, shares his expertise about stem cells in aging and neurodegenerative diseases. In this episode, Henrik explains the fascinating interplay between aging, neurodegenerative diseases and stem cells - critical areas of study that Henrik Ahlenius has passionately pursued

https://www.multipark.lu.se/article/meet-our-scientists-podcast-henrik-ahlenius-about-stem-cells-aging-and-neurodegeneration - 2025-12-07

This week marked the kickoff of MultiPark's Advanced Neuroscience Course. In this exclusive program, students from around the world unite to explore neuroscience and the complexities of neurodegenerative diseases. During the Advanced Neuroscience Course, students gain insights from leading researchers and get hands-on lab experience, working closely with labs that match their interests. The course

https://www.multipark.lu.se/article/advanced-neuroscience-course-future-neuroscientists - 2025-12-07

A study at Lund University reveals that traumatic brain injury alters the small vessels in the brain, resulting in an accumulation of amyloid beta — a hallmark of Alzheimer’s disease. The findings suggest that vascular dysfunction could be an early driver in neurodegenerative disorders rather than being caused by neuronal damage. The study is published in Acta Neuropathologica. An increased risk o

https://www.multipark.lu.se/article/cracking-alzheimers-code-how-brain-trauma-triggers-disease - 2025-12-07

This year, MultiPark has the pleasure of welcoming two new research groups. The Mackenzie Lab aims to decode the neurobiological underpinnings of emotion through experimental studies in animal models. Jacob Vogel’s team uses AI to analyze clinical data for improved understanding as well as patient-tailored diagnosis and care of neurodegenerative disease patients. Say hello to Åsa Mackenzie and Jac

https://www.multipark.lu.se/article/multipark-grows-new-research-groups - 2025-12-07

What role does an inflammatory protein have in disease development? Which neuronal circuits cause different symptoms? How may diabetes affect Parkinson’s disease? Can motor signs be identifies early in individuals at risk for the disease? And how should patients in very advanced disease stages be treated to maintain their quality of life? These questions may soon have answers thanks to several ong

https://www.multipark.lu.se/article/molecule-patient-six-promising-projects-advance-parkinsons-research - 2025-12-07

Researchers at Lund University and Washington University have identified a blood marker that reflects the amount of Alzheimer’s pathology in the brain. This discovery may play a key role in determining who is most likely to benefit from the new Alzheimer’s drugs. In brief:A newly discovered blood marker, MTBR-tau243, can reveal how much Alzheimer’s disease pathology is present in the brain. The hi

https://www.multipark.lu.se/article/new-reliable-blood-marker-reveals-extent-alzheimers-pathology-brain - 2025-12-07

A simpler method of analysing blood samples for Alzheimer’s disease has been tested in a large multicentre study, led by Lund University in Sweden. “This is a major step in bringing simple blood tests for Alzheimer’s disease into the healthcare system globally,” say the researchers behind the study. In brief:The blood-based marker (P-tau217) may start to change several years before the onset of Al

https://www.multipark.lu.se/article/more-opportunities-test-alzheimers-using-new-analytical-method - 2025-12-07

Meet our scientist Gesine Paul-Visse to learn what happens at the interface where the brain and the body meet: the blood-brain barrier. Here, a very specialized cell, the pericyte, protects the brain and responds strongly to disease. Gesine Paul-Visse leads Translational Neurology, one of MultiPark’s research groups. As both a neurologist and a researcher, she has focused on neurodegeneration for

https://www.multipark.lu.se/article/meet-our-scientists-podcast-gesine-paul-visse-about-brains-frontline - 2025-12-07

Researchers at MultiPark have uncovered in mice how the protein TDP-43, known for its role in several neurodegenerative diseases, disrupts the hypothalamus, the brain’s key center for metabolic control. Their study sheds new light on the role of TDP-43 in metabolic and psychiatric symptoms shared across frontotemporal dementia, Huntington’s disease, and ALS – findings that could support the develo

https://www.multipark.lu.se/article/protein-mismanagement-brains-control-center-fuels-early-symptoms-neurodegenerative-diseases - 2025-12-07

An experimental study from Lund University reveals for the first time that different Parkinson’s medications affect brain activity in distinct ways. This could explain why some patients develop impulsive and compulsive behaviors as a result of their treatment. The findings have been published in NPJ Parkinson’s Disease. Upon receiving treatment for their motor symptoms, many patients with Parkinso

https://www.multipark.lu.se/article/brain-activation-pattern-behind-impulsivity-parkinsons-treatment-discovered - 2025-12-07

Meet our scientist, Dr. Niklas Mattsson-Carlgren! He explains why studying biomarkers is essential to advancing Alzheimer’s research. Niklas Mattsson-Carlgren is part of the Clinical Memory Research group, a leading centre in the development and evaluation of novel biomarkers for Alzheimer’s disease. In this podcast episode, he discusses why biomarker research is key not only to detecting but also

https://www.multipark.lu.se/article/meet-our-scientists-podcast-niklas-mattsson-carlgren-about-biomarkers-and-future-alzheimers - 2025-12-07

With over 15 research groups dedicated to Alzheimer’s disease research, MultiPark’s goal is to understand the origins of the disease, develop early diagnostics, and improve treatments. The multidisciplinary approach sheds light on the disease from several angles, bridging basic research with clinical investigations. Here are five projects. September is World Alzheimer’s Month. Globally, around 40

https://www.multipark.lu.se/article/alzheimers-awareness-five-research-projects-shaping-future-understanding-diagnosis-and-care - 2025-12-07

For decades, large stretches of human DNA were dismissed as ‘junk’ and considered to serve no real purpose. In a new study in Cell Genomics, researchers at Lund University in Sweden show that the repetitive part of the human genome plays an active role during early brain development and may also be relevant for understanding brain diseases. DNA carries the complete set of instructions an organism

https://www.multipark.lu.se/article/why-repetitive-dna-matters-human-brain-evolution-and-disease - 2025-12-07

Enormous amounts of data about Alzheimer’s Disease have been generated from clinical studies so far. Still, the molecular drivers of Alzheimer’s Disease are largely unknown. With the TAU-TIME project, Jacob Vogel aims to advance knowledge by developing an AI tool that brings together known biological mechanisms with data from patients with the disease. Recent funding from the European Research Cou

https://www.multipark.lu.se/article/time-unite-lab-and-clinic-15-million-eu-build-ai-model-alzheimers-disease - 2025-12-07

Early diagnosis is key to receiving proper care and advancing research on future therapies for neurodegenerative diseases such as Parkinson’s and dementia with Lewy bodies. New research from Skåne University Hospital and Lund University shows that combining a simple smell test with advanced spinal fluid analysis can predict these diseases with high accuracy, while sparing nearly half of patients f

https://www.multipark.lu.se/article/smell-test-cuts-need-invasive-parkinsons-screening - 2025-12-07

Researchers at Lund University in Sweden have developed a digital cognitive test for diagnosing Alzheimer's disease that is intended for use in primary care. “This digital test, which patients perform on their own with minimal involvement from healthcare personnel, improves the primary care physician's ability to determine who should be further examined by blood tests for Alzheimer's pathology ear

https://www.multipark.lu.se/article/new-digital-cognitive-test-diagnosing-alzheimers-disease - 2025-12-07