What is luminal HER2-enriched breast cancer? Breast cancer is the most common cancer amongst women worldwide. While many people think of breast cancer as a singular disease it actually represents an umbrella term covering numerous different types of tumors that are characterized by specific molecular profiles and morphologies, bearing distinct clinical implications. In this light, the adequate su

BACKGROUND: Studies have demonstrated that immunity against platelet (PLT) transfusions is dependent on recipient antigen-presenting cells (APCs) and their ability to produce nitric oxide (NO). To further analyze this, we focused on NO's major metabolite peroxynitrite (ONOO(-)) and its ability to affect PLT immunity.STUDY DESIGN AND METHODS: To address how NO and its major metabolite may mediate P

Savannas cover a wide climatic gradient across large portions of the Earth’s land surface and are an important component of the terrestrial biosphere. Savannas have been undergoing changes that alter the composition and structure of their vegetation such as the encroachment of woody vegetation and increasing land-use intensity. Monitoring the spatial and temporal dynamics of savanna ecosystem stru

In boreal forests an important part of the photo assimilates are allocated belowground to support symbiosis of ectomycorrhizal fungi (EMF). The production of EMF extramatrical mycelium can contribute to carbon (C) sequestration in soils, but the extent of this contribution depends on the composition of the EMF community. Some species can decrease soil C stocks by degrading soil organic matter (SOM

In recent decades, population increase and urban development have led to catastrophic environmental consequences. One of the principal objectives to achieve “sustainable development” is to find suitable landfills. Due to their physical characteristics, which have led to a lack of landfill sites and closeness to water bodies, agricultural fields, and residential areas, the cities of Javanrood, Pave

prevalence was reported as 1:3000-4000 worldwide, making it the main reason for blindness in the working population in industrial countries. The mutations of over 70 genes have been related to this genetic disorder, and there is generally no effective treatment, except for gene therapy for the RPE65 mutations. Hence, new molecular targets are required for novel treatment development. The signaling

Over the past decade, our understanding of brain-waste clearance underwent a revolution after the discovery of the so-called glymphatic system. The glia-lymphatic (abbreviated, glymphatic) system was first described in 2012 as a paravascular macrosystem involved in the distribution of nutrients and clearance of metabolic waste from the brain parenchyma. The main actor of the system is the cerebros

Studying migrants from Sweden to the United States, we provide new evidence on return migration during the Age of Mass Migration. Focusing on a sample of migrants and stayers observed in childhood, we document limited effects on income and occupational upgrading, but large effects on wealth. Male returnees held about twice as much wealth as stayers and about 40 percent more than staying brothers.

In this paper, we present a simple theoretical, steady-state equilibrium, predator-prey model for the joint management of marine mammals and a fish species. As an empirical case, we choose cod and grey seals in the Nordic-Baltic Sea countries, and several benefits and costs related to the latter are considered. We show that the optimal grey seal population is much lower than the actual population,