Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen presentation, generate new tumor-specific T cells, and activate tumor-infiltrating myeloid cells to remodel the tumor microenvironment, represent a prom

Increasing tree growth and mortality rates in Europe are still poorly understood and have been attributed to a variety of drivers. This study explored the role of climate drivers, management and age structure in driving changes in tree mortality rates in six Central European countries from 1985 to 2010, using the process-based vegetation model LPJ-GUESS. Simulations show a strong positive trend in

Osteoarthritis (OA) and chronic low back pain (CLBP) are common musculoskeletal disorders with substantial patient and societal burden. Nordic administrative registers offer a unique opportunity to study the impact of these conditions in the real-world setting. The Burden of Disease and Management of Osteoarthritis and Chronic Low Back Pain: Health Care Utilization and Sick Leave in Sweden, Norway

Monocytes are key players in innate immunity, with their ability to regulate inflammatory responses and combat invading pathogens. There is a growing body of evidence indicating that long non-coding RNA (lncRNA) participate in various cellular biological processes, including the innate immune response. The immunoregulatory properties of numerous lncRNAs discovered in monocytes remain largely unexp

A prediction model based on artificial neural networks is adapted to forecast the acoustic performance of airborne sound insulation of various lightweight wooden façade walls. A total of 100 insulation curves were used to develop the prediction model. The data are laboratory measurements of façade walls in one-third-octave bands (50 Hz–5 kHz). For each façade wall, geometric and physical informati

Tensions between migration enforcement and migrants’ health and rights have gained renewed urgency during the COVID-19 pandemic. This article critically analyses how the pandemic has affected detained and deportable people in Sweden. Building on an activist methodological approach and collaboration, based on a survey conducted inside Swedish detention centres during the pandemic and the authors’ r

Near surface geophysics are gaining widespread use in major infrastructure projects with respect to geotechnical and engineering applications. The development of data acquisition, processing tools and interpretation methods have optimized survey production, reduced logistics costs and increase results reliability of seismic surveys during the last decades. However, the use of geophysical methods u

A substantial portion of molecules in an organism are involved in regulation of a wide spectrum of biological processes. Several models have been presented for various forms of biological regulation, including gene expression regulation and physiological regulation; however, a generic model is missing. Recently a new unifying theory in biology, poikilosis, was presented. Poikilosis indicates that

Detta kapitel har för avsikt att inspirera till metoder för ett alternativt sätt att bedriva forskning och antirasistiskt socialt arbete. Med avstamp i Lena Dominellis analys av hur vi är fångade i en rasistisk och patriarkal världsordning och hur detta drabbar väldigt många människor och samhällen, diskuterar vi med Asylkommissionen som exempel våra erfarenheter av en forskningspraktik med antira

Background: An understudied variant of Alzheimer's disease (AD), the behavioral/dysexecutive variant of AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), a

The need for increaseding accuracy and reduced ambiguities in the inversion results has resulted in focus on the development of more advanced inversion methods of geophysical data. Over the past few years more advanced inversion techniques have been developed to improve the results. Real 3D-inversion is time consuming and therefore often not the best solution in a cost-efficient perspective. This

Parkinson’s disease (PD) is a complex, chronic, and progressive neurodegenerative disease that is characterized by irreversible dopaminergic neuronal loss in the substantia nigra. Alpha-synuclein is normally a synaptic protein that plays a key role in PD due to pathological accumulation as oligomers or fibrils. Clustered alpha-synuclein binds to the Toll-like receptors and activates the microglia,

Multi-component reflection methods have gained acceptance for near surface mapping during recent years. Two case studies from Denmark employing shear wave reflection at different survey scales are presented. The first case study is a small site scale investigation to image the near surface lithology of a contaminated site. Here the S-wave reflection mapping was employed to update the Conceptual SiMulti-component reflection methods have gained acceptance for near surface mapping during recent years. Two case studies from Denmark employing shear wave reflection at different survey scales are presented. The first case study is a small site scale investigation to image the near surface lithology of a contaminated site. Here the S-wave reflection mapping was employed to update the Conceptual Si

Detailed simulations for terahertz quantum cascade lasers based on two-well designs are presented. We reproduce the maximal operation temperatures observed and attribute the degradation with temperature to the occupation of parasitic levels and thermal backfilling. Furthermore, we demonstrate that the current injection can be conveniently studied by using states, which combine energy selectivity a

The influence of tab size and location on the flow structure, distribution of pressures on the surface, and heat transfer in the separation region behind the backward-facing step at Reynolds number Re = 4000 was experimentally investigated. The effect of tabs on the distribution of the local pressure and heat transfer coefficients in the longitudinal and transversal directions was studied. The pre

Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC) cause gastrointestinal infection and, in severe cases, hemolytic uremic syndrome which may lead to death. There is, to-date, no therapy for this infection. Stx induces ATP release from host cells and ATP signaling mediates its cytotoxic effects. Apyrase cleaves and neutralizes ATP and its effect on Stx and EHEC infection was the