Microfluidic Stress Device to Decouple the Synergistic Effect of Shear and Interfaces on Antibody Aggregation
Protein denaturation and aggregation resulting from the effects of interfacial stress that can be enhanced by flow and shear stress pose significant challenges in the production of therapeutic proteins such as monoclonal antibodies. The influence of flow on protein stability is closely intertwined with interfacial effects. In this study, we have developed a microfluidic device capable of exposing