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Objectives: Coagulation test results may be affected by hemolysis, icterus and/or lipemia (HIL). Detailed guidelines for HIL-management are missing, both for manual and automatic HIL-checks. The aim of this survey was to provide an overview of the practical procedures for the detection and handling of HIL-samples used by laboratories in Europe in the context of coagulation testing. Methods: A Surv

Background and aims: The relationship between uncommon phenotypes, such as metabolically healthy obesity and normal weight with metabolic syndrome (MetS), and cardiovascular disease (CVD) risk, remains unclear. We investigated how different combinations of body mass index (BMI) and MetS are associated with overall and specific CVDs and how the number of MetS components influences CVD risk in indiv

Purpose: Children and youth with disabilities are at increased risk of abuse a major societal and public health problem in Cameroon. The aim was to explore the causes of abuse among children and youth with disabilities in homes and institutions in the Northwest Region of Cameroon. Methods: A qualitative study was conducted, including 50 in-depth interviews with children and youth with disabilities

Understanding the interplay between human brain structure and function is crucial to discern neural dynamics. This study explores the relation between brain structure and macroscale functional activity using subject-specific structural connectome eigenmodes, complementing prior work that focused on group-level models and geometry. Leveraging data from the Human Connectome Project, we assess accura

In this work, we revisit unweighted event generation for multi-parton tree-level processes in massless QCD. We introduce a two-step approach, in which initially unweighted events are generated at leading-colour (LC) accuracy, followed by a reweighting of these events to full-colour (FC) accuracy and applying an additional unweighting cycle. This method leverages the simple structure of LC integran

BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy

Insulin secretion from vesicles within pancreatic beta cells occurs through the rapid (≤10 ms) process of exocytosis. A crucial final step in this process is the formation of a fusion pore, which connects the insulin vesicle interior to the extracellular space and insulin secretion rate. We employed real-time single-cell amperometry (SCA) with microsensors to quantitatively and dynamically monitor

Type 1 diabetes (T1D) and other autoimmune diseases (AIDs) often co-occur in families. Leveraging data from 58,284 family trios in Finnish nationwide registers (FinRegistry), we identified that, of 50 parental AIDs examined, 15 were associated with an increased T1D risk in offspring. These identified epidemiological associations were further assessed in 470,000 genotyped Finns from the FinnGen stu

BACKGROUND: The risk of infection-related death is high in patients undergoing dialysis. This study aimed to identify the modifiable risk factors for PD-related infections in patients undergoing peritoneal dialysis.METHODS: This was a population-based retrospective cohort study conducted in Skåne, South Sweden, which included all patients receiving peritoneal dialysis (PD) between 2011 and 2020. T

An abnormal blood pressure (BP) response on standing is associated with atherosclerotic cardiovascular disease (CVD). The role of physical activity (PA) on orthostatic BP-reactions and its relation to subclinical atherosclerosis is unclear. We aimed to assess the association between PA and orthostatic BP-reactions, and whether PA modifies the relationship between orthostatic BP-reactions and subcl

This thesis analyzes the effects of technological change using the case ofelectrification in 20th-century Sweden. It begins with a systematic literaturereview that identifies gaps in the quantitative research on historical jobdisplacement before 1980. In Sweden, electrification enhanced labor andreduced income inequality. Analysis of 1930 census data shows that earlyelectricity access raised incom

Teams are dynamic systems that develop, adapt, and change as members interact and respond to their environments. Theory in organizational research emphasizes that team phenomena are multilevel, temporal, and often nonlinear. Yet, the statistical methods commonly used to study teams have lagged behind these theoretical advances, limiting empirical progress. This dissertation addresses this methodol

Longitudinal assessment of brain atrophy, particularly in the hippocampus, is a well-studied biomarker for neurodegenerative diseases, such as Alzheimer’s disease (AD). Estimating brain progression patterns can be applied to understanding the therapeutic effects of amyloid-clearing drugs in research and detecting the earliest sign of accelerated atrophy in clinical settings. However, most state-of

We propose an extended Left-Right symmetric model with an additional global U(1)X symmetry, which collapses to a residual subgroup ℤ2 after spontaneous symmetry breaking. In this model, the light active neutrino masses are generated via a double seesaw mechanism with the Dirac submatrix arising at one loop. In addition, the masses of the charged fermions of the Standard Model (SM) that are lighter

Background: We aimed to study the long-term effect of smoking on coronary atherosclerosis progression at the segmental level. Methods: Angiographic data (1989-2017) on current, former, and nonsmokers were collected from the Swedish Coronary Angiography and Angioplasty Registry. The Western Denmark Heart Registry was used to validate the results. Patients with clinically indicated angiography with

Background and objective: We established prognostic nomograms incorporating prostate-specific membrane antigen (PSMA) positron emission tomography (PET) parameters standardised by Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE; PPP1). Here, we develop an updated PPP2 risk score from a large international multicentre registry study. Methods: We included 6128 prostate cancer pati

[Background/Context] AI assistants like GitHub Copilot are transforming software engineering; several studies have highlighted productivity improvements. However, their impact on code quality, particularly in terms of maintainability, requires further investigation. [Objective/Aim] This study aims to examine the influence of AI assistants on software maintainability, specifically assessing how the