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Validity of polymyalgia rheumatica diagnoses and classification criteria in primary health care

Objectives: PMR is an inflammatory disease with prominent morning stiffness and muscular tenderness, usually diagnosed in primary health care (PHC). The objectives were to examine the validity of PMR diagnoses in PHC and to validate the use of classification criteria for PMR.Methods: Medical records for patients with a registered PMR diagnosis at two PHC facilities were reviewed. Patients were cla

Guilt-tripping : On the relation between ethical decisions, climate change and the built environment

The curiosity of how the built environment, implicitly and explicitly, affects how citizens and users make choices in their everyday life related to climate change is on the rise. If there is a nicely designed bike lane, the choice to bike to work is much more easily taken than if the only option is a densely trafficked road. But which responsibility does the built environment have for citizens to

Tumor‐associated humoral cytotoxicity in patients with acute myelogenous leukemia before and after chemotherapy

Sera of eight unselected adult patients with acute myelogenous leukemia obtained before and after chemotherapy were repeatedly tested for specific complement‐dependent cytotoxicity against autochthonous peripheral white blood cells from the acute leukemia stage and from the remission stage, respectively. Complement‐dependent cytotoxicity against white blood cells from the acute leukemia stage was

“The Great Initiate of God’s Grace” : A Kontakion on Saint Nicholas by Pseudo-Romanos [translated with Thomas Arentzen] with an introduction by Uffe H. Eriksen

During the ninth and tenth centuries, St Nicholas of Myra became increasingly popular as a saint, eventually rising to rank of the apostles in veneration. This article presents an investigation into the monastic piety which brought St Nicholas onto the stage of the Byzantine liturgical storyworld as one of the most important saints. Through a closer examination of how he was presented from the nin

Sibling correlation in risk attitudes : evidence from Burkina Faso

This study uses sibling correlation to provide novel descriptive evidence of parental and household characteristics on three different risk domains collected in a nationally representative survey from Burkina Faso. The sibling correlations are between 0.51 and 0.83. The correlations are higher in the general risk domain compared to risk taking in financial matters and traffic. Moreover, the siblin

The Pahlavis and the Other Side of the Coins

It was with great interest that I read “Political Power of Iranian Hierocracies” by János Jany published in Comparative Civilizations Review. Writing about Iranian history is not an easy task because historical points of view have been highly politicized. Such is particularly the case when discussing the Pahlavi dynasty, particularly its founder, Reza Shah Pahlavi, and his successor, Mohammed Reza

New Kids on the Block : The Emerging Role of YAP/TAZ in Vascular Cell Mechanotransduction

YAP and TAZ are transcriptional coactivators controlled by the Hippo signaling pathway and by actin dynamics, and that are critical for cell growth and organ size control. YAP and TAZ are exquisitely sensitive to mechanical cues, such as substrate stiffness and shear stress, and the realization is growing that they play roles in arterial remodeling and aneurysm formation. This chapter discusses ho

How to detect late-onset inborn errors of metabolism in patients with movement disorders - A modern diagnostic approach

We propose a modern approach to assist clinicians to recognize and diagnose inborn errors of metabolism (IEMs) in adolescents and adults that present with a movement disorder. IEMs presenting in adults are still largely unexplored. These disorders receive little attention in neurological training and daily practice, and are considered complicated by many neurologists. Adult-onset presentations of

The genus eriastichus la salle (Hymenoptera, eulophidae, tetrastichinae) in the neotropical region, introducing 48 new species

Our knowledge of the recently described genus Eriastichus La Salle is greatly enhanced with the addition of 48 new species: E. acribis sp. nov., E. aphritis sp. nov., E. cluridis sp. nov., E. coelotis sp. nov., E. co-lenis sp. nov., E. copalensis sp. nov., E. daptilis sp. nov., E. decoris sp. nov., E. denotatis sp. nov., E. derilis sp. nov., E. diadrys sp. nov., E. dotaensis sp. nov., E. drupis sp

The exercise of discretion in international law – why constraining criteria have a proper place in the analysis of legal decision-making

In international law, the exercise of legal discretion is constrained by criteria, such as the abuse of rights doctrine and the principle of legal certainty. The hitherto research of these criteria gives reason to take up a discussion on the appropriate way of conceptualising discretion and constraining criteria. This article, in contrast to the belief of other scholars, makes a case for the under

Street Artivism on Athenian Walls : A cognitive semiotic analysis of metaphor and narrative in street art

The thesis is a collection of four papers on Greek street art (specifically situated in the city of Athens) with a focus on metaphors and narratives. The overall aim guiding this thesis is to explore how street art in times of crisis can represent sociopolitical issues and in what ways these messages can be conveyed. By using the perspective of cognitive semiotics to address this, a parallel aim i

Sleep duration is associated with protein biomarkers for cardiometabolic health : A large-scale population study

Sleep problems and short sleep duration have been linked to adverse health effects, such as cardiovascular disease and diabetes, but the mechanisms are not fully understood. Finding biomarkers could explain mechanistic pathways and help in understanding relationships between sleep and cardiometabolic health. The aim was to assess if sleep duration and sleep quality affect the cardiometabolic-relat

Single-cell sequencing in translational cancer research and challenges to meet clinical diagnostic needs

The ability to capture alterations in the genome or transcriptome by next-generation sequencing has provided critical insight into molecular changes and programs underlying cancer biology. With the rapid technological development in single-cell sequencing, it has become possible to study individual cells at the transcriptional, genetic, epigenetic, and protein level. Using single-cell analysis, an

Planning for 1000 Years : The Råängen Experiment

While traditional forms of urban planning are oriented towards the future, the recent turn towards experimental and challenge-led urban developments is characterized by an overarching presentism. We explore in this article how an experimental approach to urban planning can consider the long-term through setting-up ‘conversations with a future situation.’ In doing so, we draw on a unique experiment

Putative ligand binding sites of two functionally characterized bark beetle odorant receptors

Background: Bark beetles are major pests of conifer forests, and their behavior is primarily mediated via olfaction. Targeting the odorant receptors (ORs) may thus provide avenues towards improved pest control. Such an approach requires information on the function of ORs and their interactions with ligands, which is also essential for understanding the functional evolution of these receptors. Henc