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The deposition of α-synuclein fibrils is one hallmark of Parkinson's disease. Here, we investigate how ganglioside lipids, present in high amounts in neurons and exosomes, influence the aggregation kinetics of α-synuclein. Gangliosides, as well as, other anionic lipid species with small or large headgroups were found to induce conformational changes of α-synuclein monomers and catalyse their aggre
We examine how the gender of a sibling affects labor market outcomes and family formation. Identification is complicated by parental preferences: if parents prefer certain sex compositions over others, children’ s gender affects not only the outcomes of other children but also the existence of potential additional children. We employ two empirical strategies that both address this problem. First,
The objective of this study was to characterize the effects of silver nanoparticles on Pseudomonas aeruginosa. Their interactions with several conventional antibiotics and ability to induce a stress response were examined. Interactions between silver nanoparticles (AgNPs) and antibiotics against free-living cells and biofilm of P. aeruginosa were studied using the chequerboard method and time-kill
This study assesses the short and medium-term impact of extreme temperatures on population health and health-related costs in Germany. For 1999 to 2008, we link the universe of 170 million hospital admissions and all 8 million deaths with weather and pollution data at the day-county level. Extreme heat significantly and immediately increases hospitalizations and deaths. This finding holds irrespec
We explore the multiphase structure of the circumgalactic medium (CGM) probed by synthetic spectra through a cosmological zoom-in galaxy formation simulation. We employ a Bayesian method for modelling a combination of absorption lines to derive physical properties of absorbers with a formal treatment of detections, including saturated systems, and non-detections in a uniform manner. We find that i
This paper reports a numerical investigation on the effect of cavity geometry on fuel transport and mixing processes in a scramjet combustor with a single rear-wall-expansion cavity. The numerical solver and the LES methods were validated against available experimental data and the numerical results were shown in good agreement with the experiments. Effect of the cavity rear wall height on the non
Den reformation som inleddes för 500 år sedan kom att innebära betydande förändringar av gudstjänstfirandet i Sverige. I årets volym av Svenskt Gudstjänstliv utforskar vi motiven, förloppen och konsekvenserna.Gudstjänstreformernas motiv behandlas av Ragnar Holte och Thomas Girmalm. Holte tecknar den allmänna bakgrunden i en artikel om Luther och Melanchthon och deras mest kända skrifter. Thomas Gi
In various environments new agents may base their decisions on observations of actions taken by a few other agents in the past. In this paper we analyze a broad class of such social learning processes, and study under what circumstances the initial behavior of the population has a lasting effect. Our results show that this question strongly depends on the expected number of actions observed by new
Background: Late health consequences of treatment for childhood leukemia are well documented. Although individuals with Down syndrome (DS) have a substantially increased risk of leukemia, information on late effects in this group is almost nonexistent. The aim of this study was to evaluate the mortality and morbidity among 5-year leukemia survivors with DS. Procedure: We compared 5-year leukemia s
Trots allt prat om sekularisering är predikan ännu den i särklass vanligaste formen av offentligt tal i vårt land. Predikanter träder bokstavligen upp ”i tid och otid” (2 Tim. 4:2), liksom de har gjort genom hela kyrkans historia. De sex artiklarna i denna årsbok handlar om predikan både historiskt (”i tid”) och principiellt (”i otid”).Katarina Hallqvist och Erik Claeson har hämtat upp texter ur d
The first Cistercian monastery in medieval Sweden was Alvastra, founded in 1143. Its library is almost completely lost, only three manuscripts remain. One of these, ms. C 37 in Uppsala University Library, contains a collection of 32 complete and three incomplete sermons.The writing in the sermon collection belongs to the first half of the thirteenth century. No direct source has been found. It is
This chapter provides an overview of antisemitism in modern Russia, not necessarily chronological, but a short survey of the different ways by which antisemitism appeared over the course of the twentieth century. Zvi Gitelman has famously characterized twentieth-century Jewish-Russian relations as a “century of ambivalence” during which periods of friendly co-existence were disrupted by violent co
The invention of computers revolutionized the way of doing science and in particular the field of mathematics. Computers were faster than any human mind in doing calculations and they did not make mistakes opening a wide range of possibilities that earlier where in practice uncomputable. Scientists observe the behavior of nature and find mathematical equations that model the different phenomena. IThe efficient simulation of thermal interaction between fluids and structures is crucial in the design of many industrial products, e.g. turbine blades or rocket nozzles. The main goal of this work is to present a high order time adaptive multirate parallel partitioned coupled method for the efficient numerical solution of two parabolic problems with strong jumps in the material coefficients that
Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflamma
