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Genetic variation in caveolin-1 correlates with long-term pancreas transplant function

Pancreas transplantation is a successful treatment for a selected group of people with type 1 diabetes. Continued insulin production can decrease over time and identifying predictors of long-term graft function is key to improving survival. The aim of this study was to screen subjects for variation in the Caveolin-1 gene (Cav1), previously shown to correlate with long-term kidney transplant functi

Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease

BACKGROUND: Chronic kidney disease (CKD) is associated with accelerated cardiovascular disease and heart failure. Endothelial nitric oxide synthase (eNOS) Glu298Asp single nucleotide polymorphism (SNP) genotype has been associated with a worse phenotype amongst patients with established heart failure and in patients with progression of their renal disease. The association of a cardiac functional d

Liquid crystal phantom for validation of microscopic diffusion anisotropy measurements on clinical MRI systems.

PURPOSE:To develop a phantom for validating MRI pulse sequences and data processing methods to quantify microscopic diffusion anisotropy in the human brain.METHODS:Using a liquid crystal consisting of water, detergent, and hydrocarbon, we designed a 0.5-L spherical phantom showing the theoretically highest possible degree of microscopic anisotropy. Data were acquired on the Connectome scanner usin

Impact of month of birth on the development of autoimmune thyroid disease in the United Kingdom and Europe

CONTEXT: Viral/bacterial infection is proposed as a trigger for the autoimmune thyroid diseases (AITD): Graves' disease (GD) and Hashimoto's thyroiditis (HT). Previous studies in European Caucasian AITD subjects found higher birth rates in the autumn/winter, suggesting those born in the autumn/winter experience increased viral/bacterial exposure after birth, impacting upon immune system developmen

Optimal pulse compression via sequential filamentation

We demonstrate theoretically and experimentally a robust method based on sequential filamentation to optimize compression of high-energy pulses in gases. We gain insight into this process by comparing compression dynamics for linear- and circularly-polarized pulses.

Attosecond electron interferometry

Attosecond extreme ultraviolet light pulses have the potential to resolve the ultrafast electron dynamics that govern basic properties of atoms, molecules, and solids. Here we present three different interferometric pump-probe methods aiming to access not only the temporal dynamics, but also state specific phase information after excitation/ionization using attosecond pulses.

The high intensity HHG beamline at lund laser

We will present the new Lund HHG beamline designed for high photon flux, delivering pulse energies of more than 4 μJ per pulse in the spectral range from 20 eV to 45 eV. Focused XUV intensities above 1014 W/cm2 should become possible.

Few-cycle and phase stable OPCPA systems with high repetition rate

We present different approaches for high repetition rate, few-cycle pulse generation with μJ-level energy from compact OPCPA systems. The sources are based on octave spanning Ti:Sa oscillators with all-optical synchronization to state-of-the-art Ytterbium based amplifiers.

Compact, few-cycle OPCPA system with ultralow CEP noise

A compact, high-repetition rate OPCPA system with CEP-stable 6.3 fs pulses duration and 10 μJ of pulse energy is presented together with results from numerical simulations. First results of high harmonic generation will be shown.

Probing electron correlation on the attosecond time scale

We present experimental measurements and theoretical calculations of single and double ionization time delays in various noble gases using an interferometric method. The measured delays allow us to extract information on the electron correlation.

Femtosecond pump-probe photoelectron spectroscopy of predissociative Rydberg states in acetylene

We employ a pump-probe approach to molecular photoionization to study fast dissociation of Rydberg states in acetylene. By using time-resolved photoelectron spectroscopy to study the electronic state of the resulting ions we are able to monitor the system continuously during dissociation or rearrangement. We find that the predissociative lifetime for the 3R‴ (v′2 = 1) Rydberg state is about 150 fs