Proteins are large, complex molecules that play many critical roles in the body and are required for the structure, function, and regulation of the body’s tissues and organs. In very simple terms, a protein can be defined as a linear chain of subunits called amino acid residues. The individual amino acid residues are sequentially bonded together by peptide bonds. There are 20 standard amino acids This work is primarily about the development, validation and application of computer simulation models for intrinsically disordered proteins, both in solution and in the presence of uniformly charged, ideal surfaces. The models in question are either coarse-grained or atomistic in nature, and their applications are dependent on the specific purpose of each study. Both, Metropolis Monte Carlo and m

Change Impact Analysis (CIA) during software evolution of safety-critical systems is a labor-intensive task. Several authors have proposed tool support for CIA, but very few tools were evaluated in industry. We present a case study on ImpRec, a recommendation System for Software Engineering (RSSE), tailored for CIA at a process automation company. ImpRec builds on assisted tracing, using informati

Quantitative data comes with enormous possibilities for presenting key characteristics of the data in a very compressed form. Basic descriptive statistics, like mean and standard deviation, comprise thousands or millions of data points into single numbers. In contrast, qualitative data, with its focus on descriptions, words, and phrases does not come with such powerful tools, leading to wordy desc

Background The relationship between meniscal tears and other joint pathologies with patient-reported symptoms is not clear. We investigated associations between structural knee pathologies identified at surgery with preoperative knee pain and function in patients undergoing arthroscopic meniscal surgery. Methods This study included 443 patients from the Knee Arthroscopy Cohort Southern Denmark (KA

Continual environmental degradation and an unfair distribution of environmental burdens and benefits are two great challenges for humanity. Economic growth is often taken for granted when planning for the future. However, it is often argued that maintaining economic growth conflicts with keeping human activities adjusted to ecological boundaries and finite resources, at least for the more-develope

Background and aims Little information is available on real-life occurrence of oral thrush in COPD patients treated with ICS. We investigated oral thrush incidence in COPD patients prescribed FDC ICS/LABA therapies and assessed whether it is modulated by the ICS type, dose, and delivery device. Methods We conducted a historical, observational, matched cohort study (one baseline year before and one

We experimentally subliminally prime subjects prior to charity donation decisions by showing words that have connotations of pro-social values for a very brief time (17 ms). Our main finding is that, compared to a baseline condition, the pro-social prime increases donations by approximately 10–17 % among subjects with strong pro-social preferences (universalism values). We find a similar effect wh

The evaluation of emergency, disaster and crisis management exercises supports both individual and organisational learning, facilitates the development of response capabilities, and helps to determine whether the current level of preparedness is good enough. Nevertheless, despite its importance in the field of disaster risk management, there is a lack of a comprehensive overview of research in the

I denna artikel redovisas en sammanställning av ett stort antal broprojekt mellan den japanska huvudön Honchu och den söder därom belägna ön Shikoku. Först ges en bakgrund vad gäller andra stora hängbroar och snedkabelbroar i världen. Därefter belyses och specifieras de aktuella japanska broarna i detalj. Sammantaget är brosystemen mellan Honchu och Shikoku imponerande inte bara vad gäller spännvi

The Sahara Desert is one of the largest land-based barriers on the Earth, crossed twice each year by billions of birds on migration. Here we investigate how common swifts migrating between breeding sites in Sweden and wintering areas in sub-Saharan Africa perform the desert crossing with respect to route choice, winds, timing and speed of migration by analysing 72 geolocator tracks recording migra

Med anledning av avhandlingen "High-performance and self-compacting concrete in house building: field tests and theoretical studies of possibilities and difficulties."