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Constrained optimization of gradient waveforms for generalized diffusion encoding.

Diffusion MRI is a useful probe of tissue microstructure. The conventional diffusion encoding sequence, the single pulsed field gradient, has recently been challenged as more general gradient waveforms have been introduced. Out of these, we focus on q-space trajectory imaging, which generalizes the scalar b-value to a tensor valued entity. To take full advantage of its capabilities, it is imperati

Genome Sequence of Moraxella catarrhalis RH4, an Isolate of Seroresistant Lineage

Here we report the annotated genome sequence of Moraxella catarrhalis strain RH4, a seroresistant-lineage strain isolated from the blood of an infected patient. This genome sequence will allow us to gain further insight into the genetic diversity of clinical M. catarrhalis isolates and will facilitate study of M. catarrhalis pathogenesis.

Quantification of Human Kallikrein-2 in Clinical Samples by Selected Reaction Monitoring

Recently, the number of mass spectrometry-based quantification assays has been increased, partly due to the global efforts of chromosome-centric human proteome project (C-HPP). Our goal at the Chromosome 19 Consortium is to provide novel selected reaction monitoring (SRM) assays of proteins coded on chromosome 19. We have selected the two most useful signature peptides (NSQVWLGR and HNLFEPEDTGQR)

Continuous monitoring of summer surface water vapor isotopic composition above the Greenland Ice Sheet

We present here surface water vapor isotopic measurements conducted from June to August 2010 at the NEEM (North Greenland Eemian Drilling Project) camp, NW Greenland (77.45 degrees N, 51.05 degrees W, 2484 m a.s.l.). Measurements were conducted at 9 different heights from 0.1m to 13.5m above the snow surface using two different types of cavity-enhanced near-infrared absorption spectroscopy analyze

Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson's Disease.

Considerable progress has been made in generating fully functional and transplantable dopamine neurons from human embryonic stem cells (hESCs). Before these cells can be used for cell replacement therapy in Parkinson's disease (PD), it is important to verify their functional properties and efficacy in animal models. Here we provide a comprehensive preclinical assessment of hESC-derived midbrain do

A numerical study on flow and convective heat transfer of aviation kerosene in a vertical mini-tube at supercritical pressures

Convective heat transfer of aviation kerosene at supercritical pressures in a vertical upward tube with inner diameter 1.8 mm was numerically studied using RNG k-? turbulence model with enhanced wall treatment. The thermo-physical and transport properties of the aviation kerosene at various temperatures were obtained by a 10-species surrogate and the NIST Supertrapp software. The grid independence

A BIM-info delivery protocol

Today, with many of the technological issues of integrated information management resolved (perhaps excluding the matter of interoperability), defining the content and status of BIM information deliveries remains both a practical and a theoretical problem. New BIM tools and new design processes and procedures have led to a certain confusion of what information is needed for particular BIM uses. Th

Development of a real-time capacitive biosensor for cyclic cyanotoxic peptides based on Adda-specific antibodies.

The harmful effects of cyanotoxins in surface waters have led to increasing demands for accurate early warning methods. This study proposes a capacitive immunosensor for broad-spectrum detection of the group of toxic cyclic peptides called microcystins (∼80 congeners) at very low concentration levels. The novel analytical platform offers significant advances compared to the existing methods. Monoc

Scandinavian gender and pancake sentences : A reply to Hans-Olav Enger

In a recent NJL article (Enger 2013), Hans-Olav Enger argues against some analyses of gender and ‘pancake sentences’, in particular against Josefsson (2009). In this short contribution, I will discuss what I take to be misunderstandings in Enger (2013). In addition I will discuss some data not included in Enger’s (2013) analysis, which I will show to be crucial for the comparison between the diffe

On icing and icing mitigation of wind turbine blades in cold climate

A review on icing physics, ice detection, anti-icing and de-icing techniques for wind turbines in cold climate has been performed. Typical physical properties of atmospheric icing and the corresponding meteorological parameters are presented. For computational modeling of ice accretion on turbine blades, the LEWINT code was adopted to simulate ice accretion on an aerofoil for a 2 MW wind turbine.

The Effect and Duration of Prophylactic Platelet Transfusions Before Insertion of a Central Venous Catheter in Patients with Bone Marrow Failure Evaluated with Point-of-Care Methods and Flow Cytometry.

Patients with bone marrow failure and severe thrombocytopenia are frequently given prophylactic platelet transfusion before interventions. The clinical effects of such transfusions, however, are poorly defined. We performed a prospective observational study on patients with bone marrow failure scheduled for prophylactic platelet transfusion before the insertion of a central venous catheter. The ob

Outer membrane vesicles shield Moraxella catarrhalis β-lactamase from neutralization by serum IgG.

OBJECTIVES: The aim of this study was to detect the presence of IgG against Moraxella catarrhalis β-lactamase in healthy adults, and to determine whether outer membrane vesicles (OMVs) could protect the enzyme from inhibition by anti-β-lactamase IgG. METHODS: Transmission electron microscopy was used to detect the presence of β-lactamase in OMVs. Sera were examined by ELISA for specific IgG direct

Automatic ultrarapid activation and inhibition of cortical motor systems in spoken word comprehension

To address the hotly debated question of motor system involvement in language comprehension, we recorded neuromagnetic responses elicited in the human brain by unattended action-related spoken verbs and nouns and scrutinized their timecourse and neuroanatomical substrates. We found that already very early on, from similar to 80 ms after disambiguation point when the words could be identified from

Effects of ionic strength and ion pairing on (plant-wide) modelling of anaerobic digestion.

Plant-wide models of wastewater treatment (such as the Benchmark Simulation Model No. 2 or BSM2) are gaining popularity for use in holistic virtual studies of treatment plant control and operations. The objective of this study is to show the influence of ionic strength (as activity corrections) and ion pairing on modelling of anaerobic digestion processes in such plant-wide models of wastewater tr

Haemophilus influenzae surface fibril (Hsf) is a unique twisted hairpin-like trimeric autotransporter

The Haemophilus surface fibril (Hsf) is an extraordinary large (2413 amino acids) trimeric autotransporter, present in all encapsulated Haemophilus influenzae. It contributes to virulence by directly functioning as an adhesin. Furthermore, Hsf recruits the host factor vitronectin thereby inhibiting the host innate immune response resulting in enhanced survival in serum. Here we observed by electro

Laser therapy for refractory discoid lupus erythematosus when everything else has failed

Background: Discoid lupus erythematosus (DLE) is restricted to the skin, mostly the face, often chronic and disfiguring. Standard medical therapies include topical corticosteroids and antimalarials. This is a retrospective long-term follow-up of refractory DLE treated with different lasers and intense pulsed light (IPL). Methods and materials : Sixteen patients with histologically confirmed DLE pa