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Snowpack fluxes of methane and carbon dioxide from high Arctic tundra

Measurements of the land-atmosphere exchange of the greenhouse gases methane (CH4) and carbon dioxide (CO2) in high Arctic tundra ecosystems are particularly difficult in the cold season, resulting in large uncertainty on flux magnitudes and their controlling factors during this long, frozen period. We conducted snowpack measurements of these gases at permafrost-underlain wetland sites in Zackenbe

Roscoe Owen Brady, MD : Remembrances of co-investigators and colleagues

To celebrate the research visions and accomplishments of the late Roscoe O. Brady (1923-2016), remembrance commentaries were requested from several of his postdoctoral research fellows and colleagues. These commentaries not only reflect on the accomplishments of Dr. Brady, but they also share some of the backstories and experiences working in the Brady laboratory. They provide insights and perspec

Occupational Choices for People with Psychiatric Disabilities : Comparing Attendees and Non-Attendees at Community-Based Day Centers

Research has shown that people with psychiatric disabilities who attend a day center rate their satisfaction with daily occupations equally in comparison with non-attendees. The current study investigates which occupations the target group performs and also differences in occupational choices between attendees and non-attendees. Reported occupations were analyzed with content analysis. Day center

RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE> 100 for the repeated d

Assessment of value for resource allocation in cancer care

There has been an increased interest in ways of measuring the value of new therapeutic options in oncology. An example of this in a European context is the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS). The purpose of this study is to analyse how the value scales, exemplified with ESMO-MCBS, developed mainly to assist decisions by physicians, relate to other measures of clinical benefit and

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

Systems approaches for the study of immune signaling pathways have been traditionally based on purified cells or cultured lines. However, in vivo responses involve the coordinated action of multiple cell types, which interact to establish an inflammatory microenvironment. We employed standardized whole-blood stimulation systems to test the hypothesis that responses to Toll-like receptor ligands or

High genetic variability of vagrant polar bears illustrates importance of population connectivity in fragmented sea ice habitats

Projections by the Intergovernmental Panel on Climate Change (IPCC) and sea ice forecasts suggest that Arctic sea ice will decline markedly in coming decades. Expected effects on the entire ecosystem include a contraction of suitable polar bear habitat into one or few refugia. Such large-scale habitat decline and fragmentation could lead to reduced genetic diversity. Here we compare genetic variab

Evaluation of a temperature model for an Interior Permanent Magnet Synchronous Machine for parallel hybrid electric heavy vehicles

This paper presents a simulation model of the temperature's influence on the electromagnetic characteristics of an Interior Permanent Magnet Synchronous Machine (IPMSM). Simulation results of an IPMSM traction machine is presented, and experimental measurements verify the accuracy of the model; no load measurements provide the induced voltage as function of temperature and dynamic tests evaluate t

Organizational Image

Organizational image is a contested concept in interdisciplinary research, drawing upon organizational communication, corporate communication, organization, marketing, and public relations studies. As such, organizational image is seen as the impression of an organization that exists among both external stakeholders as well as organizational members themselves as “construed external images” and “d

PID synthesis under probabilistic parametric uncertainty

In many system identification methods, process model parameters are considered stochastic variables. Several methods do not only yield expectations of these, but in addition their variance, and sometimes higher moments. This paper proposes a method for robust synthesis of the proportional-integral-derivative (PID) controller, taking parametric process model uncertainty explicitly into account. The

On the diagnostic analysis of IEEE 1687 networks

The IEEE 1687 standard describes reconfigurable structures allowing to flexibly access the instruments existing within devices (e.g., to support test, diagnosis, calibration, etc.), by using configuration modules which act as controllable switches. The increasing adoption of this standard requires the availability of algorithms and tools to automate its usage. The resulting networks might be affec

Compressor design for silicon debug

The objective of this paper is to design a compressor for silicon debug that is suitable in an industrial Nexus environment. The compressor must operate in real-time and must be lossless. Important for the compressor is high compression ratio, low hardware cost and high throughput. We implemented the compression on an FPGA and we compared our implementation in terms of throughput and hardware cost

Perlecan domain V of Drosophila melanogaster : Sequence, recombinant analysis and tissue expression

The C-terminal domain V of the basement membrane proteoglycan perlecan was previously shown to play a major role in extracellular matrix and cell interactions. A homologous sequence of 708 amino-acid residues from Drosophila has now been shown to be 33% identical to mouse perlecan domain V. It consists of three laminin G-type (LG) and epidermal growth factor-like (EG) modules but lacks the EG3 mod

Litterära fabrikationer : JT LeRoy och Araki Yasusada - både lögn och fiktion

Litterära fabrikationer – det litterära fenomen som vanligen kallas ”bluff” eller ”bedrägeri” – har de senaste decennierna gett upphov till en moralisk och tolkningsteoretisk debatt av starkt polariserad karaktär. I centrum för problematiken står de omtvistade betydelserna av författarens identitet och intention, grundläggande litteraturteoretiska frågor som ställs på sin spets av texter som redan

Genomics, transcriptomics, and peptidomics of Daphnia pulex neuropeptides and protein hormones

We report 43 novel genes in the water flea Daphnia pulex encoding 73 predicted neuropeptide and protein hormones as partly confirmed by RT-PCR. MALDI-TOF mass spectrometry identified 40 neuropeptides by mass matches and 30 neuropeptides by fragmentation sequencing. Single genes encode adipokinetic hormone, allatostatin-A, allatostatin-B, allatotropin, Ala(7)-CCAP, CCHamide, Arg(7)-corazonin, DENam

Drosophila stardust is a partner of Crumbs in the control of epithelial cell polarity

The polarized architecture of epithelial cells depends on the highly stereotypic distribution of cellular junctions and other membrane-associated protein complexes. In epithelial cells of the Drosophila embryo, three distinct domains subdivide the lateral plasma membrane. The most apical one comprises the subapical complex (SAC). It is followed by the zonula adherens (ZA) and, further basally, by