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The transcription factor 7-like 2 (TCF7L2) gene has the strongest genetic association with type 2 diabetes. TCF7L2 also associates with latent autoimmune diabetes in adults, which often presents with a single islet autoantibody, but not with classical type 1 diabetes.
Epidemiological data on statins and breast cancer risk have been inconclusive. The aim of this study was to clarify the role of statins in breast cancer risk by studying their effect on mammographic density.
During the last decade, the interest of the international community in the concepts of disaster risk reduction and climate change adaptation has been growing immensely. Even though an increasing number of scholars seem to view these concepts as two sides of the same coin (at least when not considering the potentially positive effects of climate change), in practice the two concepts have developed
BACKGROUND: Cellular prion-related protein (PrP(c)) is a cell-surface protein that is ubiquitously expressed in the human body. The multifunctionality of PrP(c), and presence of an exposed cationic and heparin-binding N-terminus, a feature characterizing many antimicrobial peptides, made us hypothesize that PrP(c) could exert antimicrobial activity. METHODOLOGY AND PRINCIPAL FINDINGS: Intact recom
Abstract in UndeterminedAgricultural systems continuously evolve and are forced to change as a result of a range of global and local driving forces. Agricultural technologies and agricultural, environmental and rural development policies are increasingly designed to contribute to the sustainability of agricultural systems and to enhance contributions of agricultural systems to sustainable developm
Abstract The Tree Theme Method (TTM), based on occupational therapy, creative activities and life storytelling, implies that the client draws and paints trees representing certain periods in their life. The paintings are used as a starting point for the client to tell their life story with focus on everyday occupations (occupational storytelling) and shaping plans for their future (occupational st
This paper concerns scattering of an electromagnetic wave by a bounded object located inside a parallel plate waveguide. The exciting field in the waveguide is either an arbitrary source located at a finite distance from the obstacle or a plane wave generated in the far zone. In the latter case, the generating field corresponds to the lowest propagating mode (TEM) in the waveguide. The analytic tr
Om Karl Oskar Krantz (1867-1933), grundare av Lunds andra permanenta biograf och stadens första filmproducent (bl a av de första karnevalsfilmerna).
Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. The aim of this study was to search for t
Purpose - Even though noticeable improvements have been made in global health in recent years, the distribution is uneven throughout the world and many developing and low-income countries lack access to required medicine and vaccines. Thus, a model to strategically source vaccines for these nations can contribute a great deal. This paper presents an extensive review of strategic sourcing literatur
Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected f
Parasites exert important top-down control of their host populations. The host-parasite system formed by Alexandrium minutum (Dinophyceae) and Parvilucifera sinerae (Perkinsozoa) offers an opportunity to advance our knowledge of parasitism in planktonic communities. In this study, DNA extracted from 73 clonal strains of P. sinerae, from 10 different locations along the Atlantic and Mediterranean c
Whole wheat pasta offers improved nutritional value compared with regular pasta but lacks appeal to many consumers owing to its negative organoleptic properties, such as texture and taste. Various approaches have been studied to improve these properties in whole wheat products. Optimizing bran particle size showed its potential in noodles, but studies of its effects in pasta are scarce. Therefore,
Embryonic stem cells (ESCs) represent a promising source of midbrain dopaminergic (DA) neurons for applications in Parkinson disease. However, ESC-based transplantation paradigms carry a risk of introducing inappropriate or tumorigenic cells. Cell purification before transplantation may alleviate these concerns and enable identification of the specific DA neuron stage most suitable for cell therap
The reserves, production from mines, supply of aluminium to society and mass fluxes of aluminium in society was assessed using an integrated systems dynamics model (ALUMINIUM) in order to reconstruct the past and investigate potential future scenarios. The investigations for input data show that the mine- able aluminium reserves are large, but finite. We get an average value for the ultimately rec
Background: Sustainable and economically viable manufacturing of bioethanol from lignocellulose raw material is dependent on the availability of a robust ethanol producing microorganism, able to ferment all sugars present in the feedstock, including the pentose sugars L-arabinose and D-xylose. Saccharomyces cerevisiae is a robust ethanol producer, but needs to be engineered to achieve pentose suga
A search for the Standard Model Higgs boson in the decay channel H -> ZZ(()*()) l(+)l(-)l'l'(-), where l = e, mu, is presented. Proton-proton collision data at root s = 7 TeV recorded with the ATLAS detector and corresponding to an average integrated luminosity of 2.1 fb(-1) are compared to the Standard Model expectations. Upper limits on the production cross section of a Standard Model Higgs boso
