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TNF-alpha-induced self expression in human lung endothelial cells is inhibited by native and oxidized alpha 1-antitrypsin

Endothelial cells are among the main physiological targets of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). In endothelial cells TNF-alpha elicits a broad spectrum of biological effects including differentiation, proliferation and apoptosis. alpha 1-antitrypsin (AAT), an endogenous inhibitor of serine proteases plays a vital role in protecting host tissue from proteolytic

How to form planetesimals from mm-sized chondrules and chondrule aggregates

The size distribution of asteroids and Kuiper belt objects in the solar system is difficult to reconcile with a bottom-up formation scenario due to the observed scarcity of objects smaller than similar to 100 km in size. Instead, planetesimals appear to form top-down, with large 100 1000 km bodies forming from the rapid gravitational collapse of dense clumps of small solid particles. In this paper

Skandinavien och första världskriget

The centenary of the outbreak of the First World War in 1914 has spurred a lively popular and academic debate about the conflict's role in shaping the twentieth century and the European present. This article examines the war from a slightly different perspective, taking as its point of departure the impact of the war on neutral Scandinavia and its place in contemporary Scandinavian historical cons

Models and Methodology for Optimal Vehicle Maneuvers Applied to a Hairpin Turn

There is currently a strongly growing interest in obtaining optimal control solutions for vehicle maneuvers, both in order to understand optimal vehicle behavior and to devise improved safety systems, either by direct deployment of the solutions or by including mimicked driving techniques of professional drivers. However, it is nontrivial to find the right mix of models, formulations, and optimiza

"This is what we did last time". Uncertainty over landscape analysis and its procurement in the Swedish road planning process

In some European countries, landscape analysis has long been used in support of large-scale planning or major projects such as new trunk roads and mainline rail routes, in line with both the UN's Convention on Environmental Impact Assessment and the European Landscape Convention. Some countries, however, lack a regulatory framework for what should be analysed, how a landscape analysis should be co

Röde Orms många liv

Artikel om mottagandet av Röde Orm från 1940-talet till våra dagar samt en analys av romanens mediering, det vill säga de nya gestaltningar som den fått i form av till exempel spelfilm och tecknad serie.

The MAXIII storage ring

One of the primary goals of the 700MeV MAX III synchrotron radiation source is to test and gain experience with new magnet and accelerator technology. Each magnet cell is machined out of two solid iron blocks that are then sandwiched together after coil and quadrupole installation. The MAX III ring makes extensive use of combined function magnets to obtain a compact lattice. In order to obtain fle

Between Peptides and Bile Acids: Self-Assembly of Phenylalanine Substituted Cholic Acids

Biocompatible molecules that undergo self-assembly are of high importance in biological and medical applications of nanoscience. Peptides and bile acids are among the most investigated due to their ability to self-organize into many different, often stimuli-sensitive, supramolecular structures. With the aim of preparing molecules mixing the aggregation properties of bile acid and amino acid-based

Measuring Temperature Gradients over Nanometer Length Scales.

When a quantum dot is subjected to a thermal gradient, the temperature of electrons entering the dot can be determined from the dot's thermocurrent if the conductance spectrum and background temperature are known. We demonstrate this technique by measuring the temperature difference across a 15 nm quantum dot embedded in a nanowire. This technique can be used when the dot's energy states are separ

Beyond Compassion: Replacing a Blame Culture With Proper Emotional Support and Management Comment on "Why and How Is Compassion Necessary to Provide Good Quality Healthcare?".

The absence of compassion, argues the author, is not the cause of healthcare failures but rather a symptom of deeper systemic failures. The clinical encounter arouses strong emotions of anxiety, fear, and anger in patients which are often projected onto the clinicians. Attempts to protect clinicians through various bureaucratic devices and depersonalization of the patient, constitute as Menzies no

A high pressure X-ray photoelectron spectroscopy study of oxidation and reduction of Rh(100) and Rh nanoparticles

We have studied the oxidation and reduction of Rh(100) and SiO2 supported Rh particles using high pressure X-ray photoelectron spectroscopy. We show that the formation and reduction of Rh bulk oxide can be followed in situ in O-2 and CO pressures in the range of 0.1 Torr. In general, the oxidation/reduction processes are similar on Rh(100) and the nanoparticles, but there are significant differenc

Quantum mechanical approach to probing the birth of attosecond pulses using a two-colour field

We investigate the generation of even and odd harmonics using an intense laser and a weak second harmonic field. Our theoretical approach is based on solving the saddle-point equations within the strong field approximation. The phase of the even harmonic oscillation as a function of the delay between the fundamental and second harmonic field is calculated and its variation with energy is found to

Projective Least-Squares: Global Solutions with Local Optimization

Recent work in multiple view geometry has focused on obtaining globally optimal solutions at the price of computational time efficiency. On the other hand, traditional bundle adjustment algorithms have been found to provide good solutions even though there may be multiple local minima. In this paper we justify this observation by giving a simple sufficient condition for global optimality that can

From ‘Less Landfilling’ to ‘Wasting Less’: Societal narratives, socio-materiality, and organizations

Abstract in UndeterminedPurpose - The purpose of this paper is to show that organizational change depends on societal narratives - narratives about the character, history, or envisioned future of societies. Design/methodology/approach - A case study of a Swedish municipal waste management company serves as an illustration. Findings - Swedish waste governance is powered by two main narratives: "les