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Oscillometry in Chronic Obstructive Lung Disease : In vitro and in vivo evaluation of the impulse oscillometry and tremoflo devices

Impedance, or oscillometry, measurements of the respiratory system can generate information about the function of the respiratory system not possible with traditional spirometry. There are currently several instruments on the market using different perturbations. We have compared a new respiratory oscillometry instrument, the tremoflo, with Impulse Oscillometry (IOS). Patients with a physician’s d

Ibrutinib inhibits antibody dependent cellular cytotoxicity induced by rituximab or obinutuzumab in MCL cell lines, not overcome by addition of lenalidomide

Background: The Bruton's Tyrosine Kinase (BTK)-inhibitor ibrutinib is highly active in mantle cell lymphoma (MCL) but may inhibit response to anti-CD20 antibody as previously shown in CLL models. We investigated how antibody-dependent cellular cytotoxicity (ADCC) induced by type I/II anti-CD20 antibodies was affected by treatment with ibrutinib in MCL. Furthermore, we investigated if lenalidomide,

First-principles characterization of Mg low-index surfaces : Structure, reconstructions, and surface core-level shifts

In this paper, first-principles calculations provide structural characterization of three low-index Mg surfaces - Mg(0001), Mg(1010), and Mg(1120) - and their respective surface core-level shifts (SCLSs). Inspired by the close similarities between Be and Mg surfaces, we also explore the reconstruction of Mg(1120). Through the calculation of surface energies and the use of the angular-component dec

Molecular determinants of disease severity in urinary tract infection

In the urinary tract, Escherichia coli infection may result in life-threatening disease, or asymptomatic bacterial carriage, comparable to bacterial commensalism in the gut. Pathogenic strains trigger a disease provoking host response which differs depending on the infected organ. The diversity of the response reflects the virulence repertoire of the infecting strain and by the susceptibility of t

Fossil insect eyes shed light on trilobite optics and the arthropod pigment screen

Fossilized eyes permit inferences of the visual capacity of extinct arthropods1–3. However, structural and/or chemical modifications as a result of taphonomic and diagenetic processes can alter the original features, thereby necessitating comparisons with modern species. Here we report the detailed molecular composition and microanatomy of the eyes of 54-million-year-old crane-flies, which togethe

QCD dynamic effects in the neutrino absorption by the Earth’s interior at IceCube neutrino energies and above

We investigate how the uncertainties in σνN due the different QCD dynamic models would modify the neutrino absorption while they travel across the Earth. We compare the predictions of models based on the solution of the linear DGLAP equations at small-x and large-Q2 with those which impose the Froissart bound at large energies, taking into account the unitarity effects in the neutrino - nucleon cr

Stratifying comatose postanoxic patients for somatosensory evoked potentials using routine EEG

Introduction: Multimodal neurological prognostication is recommended for comatose patients after cardiac arrest. The absence of cortical N20-potentials in a somatosensory evoked potential (SSEP) examination reliably predicts poor outcome, but presence of N20-potentials have limited prognostic value. A benign routine electroencephalogram (EEG) may identify patients with a favourable prognosis who a

Cholecystomy for acute choelcystitis

During the decade 1957 through 1966, sixty-three cholecystostomies in sixty-two patients were performed in the Surgical Department, University of Lund. Fifty-five of these sixty-two patients were followed up. The mean age was seventy-one years for both sexes. The primary mortality was 20 per cent: a third died of circulatory and respiratory insufficiency; three quarters died of peritonitis, absces

Two-Way Gaze Sharing in Remote Teaching

On-line teaching situations where a tutor and their students are remote from each other mean that contact between them is reduced compared with teaching in a classroom. We report an initial study of two-way gaze sharing between a tutor and a group of students, who were in different locations. A 45-min class consisted of an introductory lecture followed by an exercise in using two software tools, o

Linkages between N turnover and plant community structure in a tundra landscape

The spatial distribution of organic soil nitrogen (N) in alpine tundra was studied along a natural environmental gradient, covering five plant communities, at the Latnjajaure Field Station, northern Swedish Lapland. The five communities (mesic meadow, meadow snowbed, dry heath, mesic heath, and heath snowbed) are the dominant types in this region and are differentiated by soil pH. Net N mineraliza

Multiscale modeling of innate immune receptors : Endotoxin recognition and regulation by host defense peptides

The innate immune system provides a first line of defense against foreign microorganisms, and is typified by the Toll-like receptor (TLR) family. TLR4 is of particular interest, since over-stimulation of its pathway by excess lipopolysaccharide (LPS) molecules from the outer membranes of Gram-negative bacteria can result in sepsis, which causes millions of deaths each year. In this review, we outl

Correction of Fabry-Pérot interference effects in phase and amplitude pulse shapers based on liquid crystal spatial light modulators

Broadband femtosecond laser pulses manipulated by pulse shapers based on a liquid crystal spatial light modulator (LC-SLM) inevitably experience periodic spectral distortions due to Fabry-Perot interference effects within the LC-SLM. We present a method, applicable to phase and amplitude pulse shapers based on dual LC-SLMs, that enables the calibration and suppression of the undesired spectral int

Probing Stark-induced nonlinear phase variation with opto-optical modulation

We extend the recently developed technique of opto-optical modulation (OOM) to probe state-resolved ac-Stark-induced phase variations of a coherently excited ensemble of helium atoms. In a joint experimental and theoretical study, we find that the spatial redirection of the resonant emission from the OOM process is different for the low-lying 1s2p state as compared with the higher-lying Rydberg st

Emerging local solidarities? Local responses to migration to non-urban communities in the south of Sweden

In a time of harshening border control and public discourses on securitisation and “crisis” at the national as well as European levels, it is of interest to explore local responses to migration, especially in areas outside of the larger cities. Local organising in support of different migrant groups, as well as more hostile or openly racist responses, are not new phenomena. However, we argue that

Multi-particle momentum correlations extracted using covariance methods on multiple-ionization of diiodomethane molecules by soft-X-ray free-electron laser pulses

Momenta of ions from diiodomethane molecules after multiple ionization by soft-X-ray free-electron-laser pulses are measured. Correlations between the ion momenta are extracted by covariance methods formulated for the use in multiparticle momentum-resolved ion time-of-flight spectroscopy. Femtosecond dynamics of the dissociating multiply charged diiodomethane cations is discussed and interpreted b