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NFAT regulates neutrophil recruitment, systemic inflammation and T-cell dysfunction in abdominal sepsis.

The signaling mechanisms regulating neutrophil recruitment, systemic inflammation and T-cell dysfunction in polymicrobial sepsis are not clear. This study explored the potential involvement of the calcium/calcineurin-dependent transcription factor, nuclear factor of activated T-cells (NFAT) in abdominal sepsis. Cecal ligation and puncture (CLP) triggered NFAT-dependent transcriptional activity in

Characterization of germline mutations of MLH1 and MSH2 in unrelated south American suspected Lynch syndrome individuals

Lynch syndrome (LS) is an autosomal dominant syndrome that predisposes individuals to development of cancers early in life. These cancers are mainly the following: colorectal, endometrial, ovarian, small intestine, stomach and urinary tract cancers. LS is caused by germline mutations in DNA mismatch repair genes (MMR), mostly MLH1 and MSH2, which are responsible for more than 85% of known germline

Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: A Phase II study of AZD0837 in patients who are appropriate for but unable or unwilling to take vitamin K antagonist therapy

Background: Some patients with atrial fibrillation (AF) cannot be treated with vitamin K antagonists (VKAs) and will therefore not receive effective thromboprophylaxis. The primary objective of the present Phase II trial (NCT00623779) was to assess the feasibility of conducting a study with a novel oral anticoagulant, the direct thrombin inhibitor AZD0837, in patients with AF unable or unwilling t

Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia

Mutation status of FLT3, NPM1, CEBPA, and WT1 genes and gene expression levels of ERG, MN1, BAALC, FLT3, and WT1 have been identified as possible prognostic markers in acute myeloid leukemia (AML). We have performed a thorough prognostic evaluation of these genetic markers in patients with pediatric AML enrolled in the Nordic Society of Pediatric Hematology and Oncology (NOPHO) 1993 or NOPHO 2004

Antimicrobials in urogenital infections

Urinary tract infections (UTIs) and male genital infections are amongst the most prevalent infections. A prudent antibiotic policy therefore has a large impact on society. The clinical classification in uncomplicated cystitis, uncomplicated pyelonephritis, complicated UTI and genital infections is useful, also for the right choice of antibiotic treatment. In this regard pharmacokinetic and pharmac

Subantarctic peatlands and their potential as palaeoenvironmental and palaeoclimatic archives

Subantarctic islands are located within the Antarctic Circumpolar Current and the southern westerly wind belt, the latter called Southern Westerlies, making them unique terrestrial archives to investigate past changes in oceanic and atmospheric circulation patterns in the southern mid-latitudes. The islands are characterised by a treeless, phanerogam-poor flora in which bryophytes are of major imp

To trade or not to trade: Firm-level analysis of emissions trading in Santiago, Chile

Whether tradable permits are appropriate for use in transition and developing economies-given special social and cultural circumstances, such as the lack of institutions and lack of expertise with market-based policies-is much debated. We conducted interviews and surveyed a sample of firms subject to emissions trading programs in Santiago, Chile, one of the first cities outside the OECD that has i

Islet amyloid polypeptide triggers limited complement activation and binds complement inhibitor C4b-binding protein, which enhances fibril formation.

Islet amyloid polypeptide (IAPP) is synthesized in pancreatic β-cells and co-secreted with insulin. Aggregation and formation of IAPP-amyloid plays a critical role in β-cell death in type 2 diabetic patients. Since Aβ-fibrils in Alzheimer's disease activate the complement system, we have here investigated specific interactions between IAPP and complement factors. IAPP fibrils triggered limited act

Performance of jet substructure techniques for large-R jets in proton-proton collisions at root s=7 TeV using the ATLAS detector

This paper presents the application of a variety of techniques to study jet substructure. The performance of various modified jet algorithms, or jet grooming techniques, for several jet types and event topologies is investigated for jets with transverse momentum larger than 300 GeV. Properties of jets subjected to the mass-drop filtering, trimming, and pruning algorithms are found to have a reduce

Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo

Neurotrophic factors are secreted proteins responsible for migration, growth and survival of neurons during development, and for maintenance and plasticity of adult neurons. Here we present a novel secreted protein named Cometin which together with Meteorin defines a new evolutionary conserved protein family. During early mouse development, Cometin is found exclusively in the floor plate and from

Antioxidant secondary metabolites from Geranium lasiopus Boiss. & Heldr.

Chromatographic studies on the EtOAc soluble portion of the MeOH extract of Geranium lasiopus led to the isolation of eight flavonoids (kaempferol (1), quercetin (2), quercetin 3-O-beta-glucopyranoside (3), quercetin 3-O-beta-galactopyranoside (4), kaempferol 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (5), quercetin 3-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside (6), kaempfer

Larger tidal volume increases sevoflurane uptake in blood: a randomized clinical study

Background The rate of uptake of volatile anesthetics is dependent on alveolar concentration and ventilation, blood solubility and cardiac output. We wanted to determine whether increased tidal volume (V-T), with unchanged end-tidal carbon dioxide partial pressure (PETCO2), could affect the arterial concentration of sevoflurane. Methods Prospective, randomized, clinical study. ASA physical status

Imaging following acute knee trauma.

Joint injury has been recognized as a potent risk factor for the onset of osteoarthritis. The vast majority of studies using imaging technology for longitudinal assessment of patients following joint injury have focused on the injured knee joint, specifically in patients with anterior cruciate ligament injury and meniscus tears where a high risk for rapid onset of post-traumatic osteoarthritis is

Simultaneously non-convergent frequencies of words in different expansions

We consider expanding maps such that the unit interval can be represented as a full symbolic shift space with bounded distortion. There are already theorems about the Hausdorff dimension for sets defined by the set of accumulation points for the frequencies of words in one symbolic space at a time. We show that the dimension is preserved when such sets defined using different maps are intersected.

Dural lesions in decompression for lumbar spinal stenosis: incidence, risk factors and effect on outcome.

INTRODUCTION: Decompression for lumbar spinal stenosis is one of the most frequent operations on the spine today. The most common complication seems to be a peroperative dural lesion. There are few prospective studies on this complication regarding incidence and effect on long-term outcome; this is the background for the current study. MATERIALS AND METHODS: Swespine, the Swedish Spine Register do

A 65 nm Single Stage 28 fJ/cycle 0.12 to 1.2V Level-Shifter

A conventional level-shifter is modified to extend the operation range down to subthreshold regime. Leakage current is reduced by utilizing transistor stacking, channel stretching, and reverse body biasing. The design has a standard-cell compliant layout and is fully integrated in a conventional digital design flow. The level-shifter is manufactured in 65 nm CMOS, and functionality is verified by