Introduction: Atopic asthma and allergic rhinitis are common chronic inflammatory diseases affecting lower airways and nasal mucosa, respectively. Several reports demonstrated frequent co-occurrence of these two diseases, however, the exact molecular mechanism has not been described. The present study aimed to investigate if small non-coding RNA might be responsible for the co-occurrence of asthma

Lung transplantion (LTx) recipients have low long-term survival and a high incidence of bronchiolitis obliterans syndrome (BOS), an inflammation of the small airways in chronic rejection of a lung allograft. There is great clinical need for a minimally invasive biomarker of BOS. Here, 644 different proteins were analyzed to detect biomarkers that distinguish BOS grade 0 from grades 1-3. The plasma

Most scholars attribute the development and ubiquity of global value chains to economic forces, treating law as an exogenous factor, if at all. By contrast, we assert the centrality of legal regimes and private ordering mechanisms to the creation, structure, geography, distributive effects and governance of Global Value Chains (GVCs), and thereby seek to establish the study of law and GVCs as rich

The Accord on Fire and Building Safety in Bangladesh (the Accord) is generally seen as a positive development in ensuring that Bangladeshi garment industry workers have access to safe working conditions. A central structural difference between the Accord and earlier corporate social responsibility (CSR) initiatives is that the Accord takes the form of an enforceable contract that directly connects

Global value chains (‘GVCs’) have become a basic operative unit of economic production. Their development over the twentieth and twenty-first centuries has resulted in immense creation of wealth while linking together individuals, companies and economies across the world. But GVCs are also a major cause for environmental degradation, carbon emissions and human rights abuses—the ‘externalities’ of

Conceptualizing how private actors can and should control their supply chains is a tricky question with both economic and legal dimensions. The topic is of extreme importance in today's global economy. On the one hand, this importance is highlighted by events such as the catastrophic and deadly collapse of the Rana Plaza factory building in Bangladesh and the economic fiasco of the Olkiluoto 3 nuc

Contracts are used to extend governance on supply chain and platform actors in ways that could not be envisaged when the foundations of current conceptualizations of contractual privity were laid down in the 19th century. This results in a stark contradiction. Firms use contracts to extend governance on actors beyond privity when it suits their interests, for example for reasons of supplychain-wid

The public management of urban space is an everyday practice that requires development. But how is creative work done in a public context? The idea of offering outdoor offices and outdoor conferences is being implemented in an open-air museum, owned by a middle-sized city in Sweden. This chapter focuses on their ambitions to be innovative, and the practices officials engage in, to innovate. The et

Businesses are an essential driver for sustainability, yet managers struggle to make decisions about their business model that actually improve their sustainability performance. In this episode, we meet Florian Lüdeke-Freund, Henning Breuer, and Lorenzo Massa, authors of the new book called ‘Sustainable Business Model Design’. They introduce the concept of sustainable business model patterns, to s

Aberrations in glycan and lectin expression and function represent one of the earliest hallmarks of cancer. Among galectins, a conserved family of β-galactoside-binding lectins, the role of Galectin-9 in immune-tumor interactions is well-established, although its effect on cancer cell behavior remains unclear. In this study, we assayed for, and observed, an association between Galectin-9 expressio

This paper studies the relationship between income inequality and carbon emissions in the United States between 1929 and 2019. We contribute to the literature by taking a long-term perspective, which allows us to study how the relationship has varied over time. Our results show that higher inequality was associated with lower emissions during the early part of the sample and higher emissions towarThis paper studies the relationship between income inequality and carbon emissions in the United States between 1929 and 2019. We contribute to the literature by taking a long-term perspective, which allows us to study how the relationship has varied over time. Our results show that higher inequality was associated with lower emissions during the early part of the sample and higher emissions towar

Rising demand for food production poses a major threat to biodiversity by placing competing pressures on land. Diversified farming systems are one widely promoted nature-based solution to this challenge, which aim to integrate biodiversity-based ecosystem services into agricultural production. The underlying theory behind this approach is that diverse communities enhance ecosystem service provisio

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that spread around the world during the past 2 years, has infected more than 260 million people worldwide and has imposed an important burden on the healthcare system. Several risk factors associated with unfavorable outcome were identified, including elderly age, selected comorbidities, immune suppression as well as laboratory markers.