Evolution of Bioengineered Lung Models : Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology
Mechanical stretch under both physiological (breathing) and pathophysiological (ventilator-induced) conditions is known to significantly impact all cellular compartments in the lung, thereby playing a pivotal role in lung growth, regeneration and disease development. In order to evaluate the impact of mechanical forces on the cellular level, in vitro models using lung cells on stretchable membrane