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Combination of the proliferation marker cyclin A, histological grade, and estrogen receptor status in a new variable with high prognostic impact in breast cancer.

Global gene expression profiles, consisting mainly of genes associated with proliferation, have been shown to subdivide histological grade 2 breast cancers into groups with different prognosis. We raised the question whether this subdivision could be done using a single proliferation marker, cyclin A. Furthermore, we combined cyclin A (CA), histological grade (G), and estrogen receptor-ER (E) into

Imaging in gynecological disease (5): clinical and ultrasound characteristics in fibroma and fibrothecoma of the ovary

Objectives To describe the clinical and ultrasound features of fibroma and fibrothecoma of the ovary. Methods Sixty-eight women with a histological diagnosis of fibroma or fibrothecoma of the ovary who had undergone a preoperative ultrasound examination between 1999 and 2007 were identified from the databases of four ultrasound centers. The tumors were characterized on the basis of ultrasound imag

Centrality dependence of low-momentum direct-photon production in Au plus Au collisions at root s(NN)=200 GeV

The PHENIX experiment at RHIC has measured the centrality dependence of the direct photon yield from Au + Au collisions at root s(NN) = 200 GeV down to pT = 0.4 GeV/c. Photons are detected via photon conversions to e(+)e(-) pairs and an improved technique is applied that minimizes the systematic uncertainties that usually limit direct photon measurements, in particular at low pT. We find an excess

The perceptions of danish physiotherapists on the ethical issues related to the physiotherapist-patient relationship during the first session: a phenomenological approach

Background: In the course of the last four decades, the profession of physiotherapy has progressively expanded its scope of responsibility and its focus on professional autonomy and evidence-based clinical practice. To preserve professional autonomy, it is crucial for the physiotherapy profession to meet society's expectations and demands of professional competence as well as ethical competence. S

Caspase 8 inhibits programmed necrosis by processing CYLD

Caspase 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner caspase 3 (ref. 1). However, the dominant function of caspase 8 is to transmit a pro-survival signal that suppresses programmed necrosis (or necroptosis) mediated by RIPK1 and RIPK3 (refs 2-6) during embryogenesis and haematopoiesis(7-9). Suppression of necrotic cell death by c

Partnering relationships in construction: A literature review

There is no unified view as to what partnering relationships are in the construction industry. The purpose of this paper is to examine the literature in order to identify the main assumptions about partnering relationships in construction research and practice. The literature is compared to the Construction Industry Institute's (CII, 1991) frequently cited definition of partnering as a long-term c

A folded and immunogenic IgE-hyporeactive variant of the major allergen Phl p 1 produced in Escherichia coli.

Group 1 grass pollen allergens are a major cause of allergic disease. Specific immunotherapy involving controlled administration of allergens can be used as a disease-modifying treatment for such disease. Recombinant allergen variants with reduced IgE binding capacity may be used as component in such vaccines, as they may induce fewer treatment side effects than materials currently in use. A mutat

Att analysera Sanningens rörlighet. Objektivitet, politik och fält.

I den här artikeln argumenteras för att etnologin har viktig forskningsuppgift i att studera Sanningens rörlighet i termer av kulturella processer, närmare bestämt att besvara frågorna hur, var, när, vem och varför. För att föra det ser författaren ett fruktbart analytiskt angreppssätt i att kombinera diskursteoretiska begrepp och sociologiska och hämtar inspiration från såväl Laclau och Mouffe oc

Changes in experienced value of everyday occupations after nature-based vocational rehabilitation

Objective: The aim of this study was to describe and assess changes in participants' experiences of everyday occupations after nature-based vocational rehabilitation (NBVR), to assess changes regarding symptoms of severe stress and the rate of return to work and possible association with experiencing the occupational value of everyday occupations. Methods: The NBVR was carried out by a transdiscip

Search for massive long-lived highly ionising particles with the ATLAS detector at the LHC

A search is made for massive highly ionising particles with lifetimes in excess of 100 ns, with the ATLAS experiment at the Large Hadron Collider, using 3.1 pb(-1) of pp collision data taken at root s = 7 TeV. The signature of energy loss in the ATLAS inner detector and electromagnetic calorimeter is used. No such particles are found and limits on the production cross section for electric charges

Macrophages and Neutrophils in ANCA Associated Vasculitis

Autoimmune diseases are diseases where the immune system attacks the body itself. They are commonly complex diseases with no clear aetiology, a fact that complicates treatment and the study of these diseases. This thesis focuses on the rare group of autoimmune diseases ANCA associated vasculitides (AAV) that are characterized by the presence of anti-neutrophil cytoplasmic antibodies (ANCA) direct

Façade Fires in Swedish School Buildings

Fires outside school buildings caused by arson are a major problem in Sweden. The initial fire source can involve rubbish or other types of combustibles that can be found at or sometimes brought to the school. As the external fire develops the flames will extend along the façade. If the building is a one-story building, which is a common construction in Swedish school buildings, the fire can sprea

Weakly Deformed Oblate Structures in 198Os

Gamma rays de-exciting isomeric states in the neutron-rich nucleus Os-198(76)122 have been observed following relativistic projectile fragmentation of a 1 GeV per nucleon Pb-208 beam. The ground-state band has properties compatible with oblate deformation. The evolution of the structure of Os isotopes characterized by sudden prolate-oblate shape change is discussed and contrasted with the smooth c

On the Analytical Representation of Chip Area and Tool Geometry when Oblique Turning with Round Tools. Part 1: Chip Area Parameters under Variation of Side and Back Rake Angle

Chip area parameters, such as undeformed chip thickness, equivalent chip thickness, contact edge length, etc., along with tool angles are among defining for the mechanical and thermal conditions of the cutting process. This paper considers the case of external turning with a round insert under variation, in wide range, of back and side rake angles and their influence on the main chip area and surf

Racist dreams and municipal budgets: women representing a culturally racist party in local politics

The welfare and migration regime of Sweden are undergoing substantial changes, as neo-liberal restructuring is rapidly increasing inequalities, and multicultural policies are in retreat as neo-assimilationist policies are growing. In 2014, the Sweden Democrats, a party conceptualised as culturally racist, was re-elected with 13% of the votes, with a presence in almost all municipalities. While sch

Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease.

Chronic obstructive pulmonary disease (COPD) independently associates with an increased risk of coronary artery disease (CAD), but it has not been fully investigated whether this co-morbidity involves shared pathophysiological mechanisms. To identify potential common pathways across the two diseases, we tested all recently published single nucleotide polymorphisms (SNPs) associated with human lung