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Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development.

Sphingolipids are abundant in the microvillar membrane of intestinal epithelial cells where they are essential for structural integrity and may act as receptors for toxins, virus and bacteria. Metabolism of dietary and membrane sphingolipids in the intestine generates ceramide, sphingosine, sphingosine-1-phosphate, and ceramide-1-phosphate, via the action of alkaline sphingomyelinase, neutral cera

Instrumentalized History and the Motif of Repetition in News Coverage of Japan-Taiwan Relations

Examining the coverage in seven major Japanese and Taiwanese daily newspapers of a selection of events involving both societies in the first decade of the twenty-first century, this paper investigates the phenomenon of rhetorical instrumentalization of the past for present ideological purposes. The concerns of this study are the processes of dehistorization in Japanese and Taiwanese news and publi

The development of a full-scale room fire test

A large-scale room calorimeter has been developed for testing surface lining materials as well as furniture and other fittings. Heat release rates in the fire room have been measured in various ways. The technique based on oxygen consumption was deemed to be the most suitable for a standard test. A hood has therefore been built to collect all the fire gases leaving the room; thus, the rates of pro

Collaboration between relatives of elderly patients and nurses and its relation to satisfaction with the hospital care trajectory.

BACKGROUND: Relatives are often involved in the care of frail elderly patients prior to admission and are thus important collaborative partners for nurses. They hold valuable knowledge, which may improve care planning for the benefit of the patient and the hospital care trajectory. Satisfaction among relatives may be an indicator of this. Aim: To investigate collaboration between relatives and nur

Robot-assisted laparoscopic hysterectomy in obese and morbidly obese women: surgical technique and comparison with open surgery.

Objective. Comparison of surgical results on obese patients undergoing hysterectomy by robot-assisted laparoscopy or laparotomy. Setting. University hospital. Methods. All women (n=114) with a BMI ≥30 kg/m(2) who underwent a simple hysterectomy as the main surgical procedure between November 2005 and November 2009 were identified. Robot-assisted procedures (n=50) were separated into an early (lear

Chemical sensing with laser spectroscopy

Laser spectroscopic techniques constitute powerful tools for chemical sensing. Atoms and molecules can be identified and quantified by their specific spectral signatures and the strength of the signals. A wide variety of methods for establishing spectroscopic contact with the species exist: absorption, emission, fluorescence, Raman scattering, acousto-optic, and opto-galvanic phenomena can be empl

Biological effects of a disposable, canisterless negative pressure wound therapy system.

Objective: Recent developments of negative pressure wound therapy (NPWT) systems have focused on making pumps smaller, lighter, and more portable. The recently introduced PICO system manages wound fluid through a highly breathable film within the dressing, thereby negating the need for a canister, which allows greater mobility and patient concordance. The aim of this study is to compare the biolog

On some Nonlinear Aspects of Wave Motion

In the first part of this thesis we consider the governing equations for capillary water waves given by the Euler equations with a free surface under the influence of surface tension over a flat bottom. We look for two-dimensional steady periodic waves. The problem is first transformed to a nonlinear elliptic equation in a rectangle. Using bifurcation and degree theory we then prove the existence

Cancer risk in patients hospitalized with polymyalgia rheumatica and giant cell arteritis: a follow-up study in Sweden.

Objectives. Studies reporting cancer risk after PMR and GCA are few, but it remains an issue of both concern and controversy. We examined the overall and specific cancer risks among Swedish subjects following hospitalization for these diseases. Methods. PMR and GCA patients were identified from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. Follow-up of patie

Against Truthmaker Necessitarianism

This paper is an argument against Truthmaker Necessitarianism — the doctrine that the existence of a truthmaker necessitates the truth of the proposition it makes true. Armstrong’s sufficiency argument for necessitarianism is examined and shown to be question begging. It is then argued in detail that truthmaking is a matter of grounding truth and that grounding is a dependency relation that neithe

Impact of Human Papillomavirus (HPV)-6/11/16/18 Vaccine on All HPV-Associated Genital Diseases in Young Women.

Background The impact of the prophylactic vaccine against human papillomavirus (HPV) types 6, 11, 16, and 18 (HPV6/11/16/18) on all HPV-associated genital disease was investigated in a population that approximates sexually naive women in that they were "negative to 14 HPV types" and in a mixed population of HPV-exposed and -unexposed women (intention-to-treat group). Methods This analysis studied

Mapping of deletion breakpoints at the CDKN2A locus in melanoma: detection of MTAP-ANRIL fusion transcripts.

Genomic locus at chromosome 9p21 that contains the CDKN2A and CDKN2B tumor suppressor genes is inactivated through mutations, deletions and promoter methylation in multiple human cancers. Additionally, the locus encodes an anti-sense RNA (ANRIL). Both hemizygous and homozygous deletions at the locus targeting multiple genes are fairly common in different cancers. We in this study investigated brea