Convergent Synthesis of the Hexasaccharide Repeating Unit of the O-Antigenic OPS of Escherichia coli O133
Synthesis of the hexasaccharide repeating unit of the O-antigen from E. coli O133 has been accomplished with rational protecting group manipulations on commercially available monosaccharides and stereoselective glycosylations through a convergent protocol. A late stage TEMPO mediated oxidation is used to install the required uronic acid moiety. Chloroacetate group is used extensively as a temporar