T2D is the most widespread endocrine disease. In conventional stimulus secretion coupling increased blood glucose is metabolized causing an increased intracellular level of ATP and closure of the KATP channels, and this, in turn, depolarizes the cell membrane leading to the opening of voltage-gated Ca2+ channels, the influx of Ca2+ and exocytosis of insulin granules. This model has become almost a

Purpose: Fatigue is a major symptom of ABI. Greater fatigue is associated with cognitive impairment. Our aim was to systematically review, describe and analyse the literature on the extent of this relationship. Methods: Five databases were searched from inception. Studies were included where: participants had a defined clinical diagnosis of ABI which included TBI, stroke or subarachnoid haemorrhag

The current concept of social resilience, which developed from the classic definition of resilience, neglects social resilience as a social phenomenon including social experiences and practices in the face of change and adversity. I argue that framing social resilience as a capacity or ability undermines its characteristics as a complex and contextualized social phenomenon that contributes to adap

Climate change stressors, including warming and heatwaves, can alter plankton composition and dominance patterns in temperate shallow lakes, which can disrupt ecosystem function and curtail ecosystem services. Understanding how these alterations could take place under future climates is therefore important. To understand such changes, we performed a year-long mesocosm experiment with controls refl

Social work education has been subject to discussion throughout history. The competence of newly graduated social workers is questioned in facing complex social problems and new challenges in society. The purpose of this study has been to shed light on how newly graduated social workers’ theoretical knowledge and practical skills are perceived by managers in the exercise of authority who work clos

This study aimed to explore which understanding social work professionals have of sugar dating among youth under the age of 18. Furthermore, the purpose of the study was to discover which children engage in sugar dating from the perspective of professionals. We conducted six semi-structured interviews with different social work professionals. The findings from our interviews were analyzed through

Uppsatsen har som syfte att kritiskt granska försvarlighetsbedömningen och excessbedömningen som görs i nödvärnssituationer. Ett psykologiskt perspektiv används för att analysera huruvida Högsta domstolen har skapat en för långtgående skyldighet att fly istället för att försvara sig med våld. Det är endast nödvärn vid brottsligt angrepp på person som behandlas. Jag använder mig av den rättsdogmatiThe purpose of this essay is to critically examine the Supreme Court’s judgments regarding the justifiability of self-defense and excessive self-defense. A psychological perspective is applied to analyze if the Supreme Court has created a too extensive obligation to escape instead of using violence to defend oneself. This essay only covers self-defense from criminal attacks on a person. I use a le

Acoustic streaming at high acoustic energy densities Eac is studied in a microfluidic channel. It is demonstrated theoretically, numerically, and experimentally with good agreement that frictional heating can alter the streaming pattern qualitatively at high Eac above 400 J/m^3. The study shows how as a function of increasing Eac at fixed frequency, the traditional boundary-driven four streaming r

Women human rights defenders are the center of the thesis (WHRDs). The thesis is based on my three years of professional experience as a human rights defender, which have given me a thorough awareness of the challenges WHRDs encounters and the knowledge I obtained through the postgraduate course. Considering that I was unfamiliar with the exact challenges WHRDs faced, I wanted to examine problems

This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy and functional characterization of mouse and human dendritic cells (DC) from lymphoid organs and various nonlymphoid tissues. DC are sentinels of the immune system present in al

Arbetsgivaren har rätt att leda och fördela arbetet för sin verksamhet. Arbetstagaren har samtidigt en skyldighet att utföra arbete för sin arbetsgivare som arbetstagaren sedan betalas tillbaka i form av lön. Arbetsgivaren får däremot inte beordra arbetstagaren att utföra vilket arbete som helst eller omplacera en arbetstagare utanför ramen för anställningen om inte det finns godkända skäl för detThe employer has the right to direct and distribute the work for his own business. At the same time the employee has an obligation to carry out work for his employer in exchange for payment in the form of salary. On the other hand the employer may not order the employee to carry out all forms of labor or decide where the employee shall carry out the work. The essay clarifies what the employer’s wo

Layered double perovskites are currently being investigated as emerging halide-based materials for optoelectronic applications. Herein, we present the synthesis of Cs4MnxCd1−xSb2Cl12 (0 ≤ x ≤ 1) nanocrystals (NCs). X-ray powder diffraction evidences the retention of the same crystal structure for all the inspected compositions; transmission electron microscopy revealed monodisperse particles

In 2020, many in-person scientific events were canceled due to the COVID-19 pandemic, creating a vacuum in networking and knowledge exchange between scientists. To fill this void in scientific communication, a group of early career nanocrystal enthusiasts launched the virtual seminar series, News in Nanocrystals, in the summer of 2020. By the end of the year, the series had attracted over 850 part

Under början av 1700-talet förändrades Göteborg. Stadens invånare, tomter och bebyggelse kom i allt större utsträckning att bevaras inom en tidigmodern struktur. Göteborg 1713 – en visuell mikrohistoria är en bok som handlar om stadens invånare och deras möjligheter att själva definiera sin omgivning under århundradets inledande decennier. Staden i boken är en plats i förändring som i skuggan av s

The purpose of this study is to distinguish and understand the challenges of working within Swedens' National Board of Institutional Cares juvenile institutions and how the treatment assistants handle these challenges. Treatment assistants who work at SiS (Statens institutionsstyrelse) juvenile institutions are their shifts locked in with juveniles who have a wide range of norm-breaking behavi

High fidelity gridded temperature datasets are difficult to obtain for areas with sparse coverage of meteorological stations given that sparsity of stations is known to introduce uncertainty in the interpolation of climatic variables generally. Inspired by their potential for optimal results especially for small sample datasets, we assessed and compared the accuracy of interpolation results of Emp

Introduction: Etiological diagnosis of neurocognitive disorders of middle-old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results. Methods: Using a Delphi consensus method supported