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Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development

SARS-CoV-2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti-virals. Within the international Covid19-NMR consortium, we have identified binders targeting the RNA genome of SCoV2. We established protocols for the production and NMR characte

How research travels to policy: The case of Nordic peace research

How is peace research connected to practice? Observers have argued that peace research has gone from activist, political ideals about changing the world to being a methods-driven field of research that has lost all criticality. This article adds empirical substance to the debate by investigating the case of Nordic peace research and its relationship to practice. Through interview data with more th

Performing E-bookness : Remediation and Metamediality in the Ebook Edition of Mark Z. Danielewski's The Fifty Year Sword

Mark. Z Danielewski is known for his experiments with the aesthetics of print in works such as House of Leaves and The Familiar. The chapter examines what happens when the experimental book object is digitalized, focusing on the enhanced e-book version of Danielewski’s The Fifty Year Sword. Drawing on theories on remediation (Bolter and Grusin), bookishness (Pressman, Hayles) and digital materiali

Exploring networks of care in the end-of-life context through eco maps: : feminist perspectives on caregiving in between family, community, and professionals in Sweden

More complex understanding of relationality in care networks around patients with life-limiting illness and their significant others is needed. This is the case not only because care is distributed unequally along gendered lines, but also because of the changing landscape of care in welfare states where families and communities are made more self-responsible. This study examines everyday experienc

Sustainable meetings – communicating to enhance the industry’s resilience

There are many definitions of resilience, but in general it refers to the ability of a system, which may be a community, society, or economic system that are exposed to extreme disturbances, persistent stress, or hazards to resist, absorb, accommodate, adapt to, transform and recover from effects of the situation in a timely and efficient manner (PreventionWeb n.d.;). Sustainability is focused on

The functional impact of cognition in adults with autism spectrum disorders

Purpose and aim: The overall aim of this study was to examine the relationship between adaptive function and cognitive factors in young adults diagnosed with autism spectrum disorder (ASD) in adult age.Methods: The study included 30 adults (age 18-30) diagnosed with ASD in adulthood. All participants were clinically referred to an adult psychiatric clinic for assessment. Adaptive functioning was m

Land cover classification using machine-learning techniques applied to fused multi-modal satellite imagery and time series data

Land cover classification is one of the most studied topics in the field of remote sensing, involving the use of data from satellite sensors to analyze and categorize different land surface types. There are numerous satellite products available, each offering different spatial, spectral, and temporal resolutions. Consequently, several methodologies have been developed to efficiently determine land

Integrating Local Knowledge into the Spatial Analysis of Wind Power: The case study of Northern Tzoumerka, Greece

Increasing demand for incorporating renewable energy projects into the national energy mix, is associated with international and European efforts to tackle the negative effects of climate change and strengthen energy resilience. Greece, as a member country of the European Union, has acknowledged that necessity, by implementing a national program aiming to significantly reduce Green House Gas Emiss

Clique Is Hard on Average for Unary Sherali-Adams

We prove that unary Sherali-Adams requires proofs of size nΩ(d) to rule out the existence of an nΘ(1)-clique in Erdős-Rényi random graphs whose maximum clique is of size d ≤ 2 log n. This lower bound is tight up to the multiplicative constant in the exponent. We obtain this result by introducing a technique inspired by pseudo-calibration which may be of independent interest. The technique involves

Physiotherapists' training in oncology rehabilitation from entry-level to advanced education : A qualitative study

BACKGROUND AND PURPOSE: Physiotherapy is gaining a central role in oncology. However, the training and competencies needed by physiotherapists in oncology rehabilitation are still unclear. This study aims to articulate the training trajectory of physiotherapists in oncology rehabilitation from entry-level education to advanced education degrees.METHODS: Qualitative focus group study following a 'R

Wearable Devices to Improve Physical Activity and Reduce Sedentary Behaviour : An Umbrella Review

BACKGROUND: Several systematic reviews (SRs), with and without meta-analyses, have investigated the use of wearable devices to improve physical activity, and there is a need for frequent and updated syntheses on the topic.OBJECTIVE: We aimed to evaluate whether using wearable devices increased physical activity and reduced sedentary behaviour in adults.METHODS: We conducted an umbrella review sear

Shared reading för patienter med anorexia nervosa: En reflexiv tematisk analys av deltagares och läsledares upplevelser

Shared reading är en läsfrämjande metod som, inom ramen för ett forskningsprojekt, har varit en del av behandlingen dagvård för patienter med anorexia nervosa. Föreliggande studie undersökte deltagarnas och läsledarnas upplevelser av shared reading. Sju semistrukutrerade intervjuer genomfördes, fem med deltagare och två med läsledare, och analyserades med reflexiv tematisk analys. Analysen av inteShared reading is a literature-promoting method that, as part of a research project, has been incorporated into the day care treatment for patients with Anorexia nervosa. The present study explored the experiences of participants and reader leaders involved in Shared reading. Seven semi-structured interviews were conducted, five with participants and two with reader leaders, and were analyzed usin

The underlying order : Isomerism as a blueprint to control the behavior of sugar-based (bio)surfactants

Surfactants are ubiquitous in formulated products and technologies. As one of the most important commodity chemicals, their remarkable consumption leads to the necessity of finding sustainable alternatives. Although the use of renewable sources limits the available chemical space for a “Green” production, the great variety of naturally occurring precursors, i.e., fatty acids and sugars, opens a my

Superdeformation in the N = z Nucleus 36Ar : Experimental, deformed mean field, and spherical shell model descriptions

A superdeformed rotational band has been identified in 36Ar, linked to known low-spin states, and observed to its high-spin termination at Iπ = 16+. Cranked Nilsson-Strutinsky and spherical shell model calculations assign the band to a configuration in which four pf-shell orbitals are occupied, leading to a low-spin deformation β2 ≈ 0.45. Two major shells are active for both protons and neutrons,

Marital status and cause-specific mortality : A population-based prospective cohort study in southern Sweden

The aim was to investigate associations between marital status and mortality with a prospective cohort study design. A public health survey including adults aged 18–80 was conducted with a postal questionnaire in southern Sweden in 2008 (54.1% participation). The survey formed a baseline that was linked to 8.3-year follow-up all-cause, cardiovascular (CVD), cancer and other cause mortality. The pr

Sahara's surface transformation forced an abrupt hydroclimate decline and Neolithic culture transition in northern China

The remote forcing from land surface changes in the Sahara is hypothesized to play a pivotal role in modulating the intensity of the East Asian summer monsoon (EASM) through ocean-atmospheric teleconnections. This modulation has far-reaching consequences, particularly in facilitating societal shifts documented in northern China. Here, we present a well-dated lake-level record from the Daihai Lake

Workshop 1 report : Regulatory regimes: National and comparative regulation of public transport

This workshop considered whether there was a need for a fourth way (or ways) to organise and regulate public transport to complement the three existing models of classic regulation, deregulation and limited competition (including competition for the market). This was particularly viewed from the perspective of what constitutes a good (public) transport authority. The evidence was based on five sou

Enabling battery circularity : Unlocking circular business model archetypes and collaboration forms in the electric vehicle battery ecosystem

Achieving battery circularity is crucial for meeting the targets of net-zero emission vehicles by 2030 and enabling climate-neutral transportation by 2050. To facilitate this transition, firms operating in the electric vehicle (EV) battery ecosystem must reassess their value creation, capture, and delivery methods. Although EV battery second life presents a promising solution for circularity, many