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Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of
Introduction: Central venous access devices facilitate home treatment in boys with haemophilia. These are usually fully implanted lines, referred to as ports. Caregivers are taught to manage the port using sterile techniques and maintaining patency by flushing with saline or heparin solution. National and international guidelines for the home care of ports are lacking. Aim: To evaluate if infectio
Background: The Autism Diagnostic Interview-Revised (ADI-R) is considered a first choice assessment tool in autism spectrum disorder. Nevertheless, despite its wide use in psychiatric practice and recommendations by various clinical guidelines, its interrater reliability has predominantly been confirmed in research settings by specially trained, research reliability interviewers. The reliability o
Late medieval towns have often been neglected within the urban archaeological paradigm. This article tries to discuss the medieval urbanization from the perspective of small late medieval towns in relation to other types of central places by using a regional perspective. The towns of Vimmerby and Eksjö, and the central places of Värnamo and Vetlanda in Småland are used as examples. In this region,
Denna bok är avsedd att vara en vägledning och fördjupning till utställningen Skatter i Skåneland. Boken innehåller dels en kronologisk översikt över såväl det historiska som det numismatiska skeendet i Skåneland under den tid när man där präglade mynt, och dels spännande historier kring de myntfynd som visas i utställningen. Tanken är att boken skall vara besökaren till nytta i utställningen men
This book is intended as a guide to the exhibition "Treasures in Skåneland”, providing further information. The book contains a chronological survey of general and numismatic history in Skåneland during the time when coins were minted here, as well as descriptions of the coin finds on show in the exhibition. The idea is that the book will be of use to visitors in the exhibition, while also making
Solid tumors in childhood are extremely rare entities, which are usually treated in specialized centers. Diagnosis and therapy are carried out according to a joint European protocol, whereby the pathological evaluation and therapy are carried out according to international guidelines. For the correct diagnosis and/or therapy of most tumors, analysis of specific genetic changes is mandatory; theref
We present the suggested temperature control system of the future ESS phase-reference line. The poster describes modeling, simulation, choice of hardware components, control algorithm, and measurement results from a 4.5 meter prototype developed at the Department of Automatic Control at Lund University in close collaboration with the European Spallation Source (ESS). The measurement results indica
Background: Lung cancer is the leading cause of cancer death. Little is known about whether prediagnostic nutritional factors may affect survival. We examined the associations of prediagnostic calcium intake from foods and/or supplements with lung cancer survival. Methods: The present analysis included 23,882 incident, primary lung cancer patients from 12 prospective cohort studies. Dietary calciu
Objectives. To assess the prevalences across Europe of radiological indices of degenerative inter-vertebral disc disease (DDD); and to quantify their associations with, age, sex, physical anthropometry, areal BMD (aBMD) and change in aBMD with time. Methods. In the population-based European Prospective Osteoporosis Study, 27 age-stratified samples of men and women from across the continent aged 50
Massive MIMO (MaMIMO) is a key technology for 5G wireless communication, enabling large increase in both spectral and energy efficiency at the same time. Before it can be deployed, it is important to find efficient implementation strategies. Because of the many antennas, an essential part of decreasing complexity, and further improving energy efficiency, is optimization of the digital signal proce
OBJECTIVE: Identification of the causal mutation in an African-American family with adult-onset primary dystonia. BACKGROUND: The vast majority of patients with dystonia are adults with primary focal or segmental anatomical distributions. Familial and sporadic dystonia appear to share the same genetic etiological background. Although approximately 10% of probands have at least one first- or second
Purpose: Packaging adds weight and volume to food products, thereby increasing the environmental impact of transport processes. This research examines the relative importance of transport efficient packaging in food supply chains that rely on road transport compared to other environmental requirements, such as packaging material minimization and food waste reduction.Design/methodology/approach: Sc
