Tyrosine kinase inhibitors targeting the BCR-ABL oncoprotein in chronic myeloid leukemia (CML) are remarkably effective inducing deep molecular remission in most patients. However, they are less effective to eradicate the leukemic stem cells (LSC), resulting in disease persistence. Therefore, there is great need to develop novel therapeutic strategies to specifically target the LSC. In an experime

The opportunity of integrating pervaporation within the concept of waste water treatment to recover organic compounds has been widely recognized. Within this paper a process simulation is developed as a design tool to analyse and optimize the process of hydrophobic pervaporation. In the simulation the mass transfer through the membrane and concentration boundary layer are described using a resista

Background: When discontinuation in COPD randomized controlled trials (RCTs) is unevenly distributed between treatments (differential dropout), the capacity to demonstrate treatment effects may be reduced. We investigated the impact of the time of differential dropout on exacerbation outcomes in RCTs, in relation to study duration and COPD severity. Methods: A post hoc analysis of 2,345 patients f

Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were i

Most reductionist accounts of intentional joint action include a condition that it must be common knowledge between participants that they have certain intentions and beliefs that cause and coordinate the joint action. However, this condition has typically simply been taken for granted rather than argued for. The condition is not necessary for ensuring that participants are jointly responsible for

This article presents two formerly unedited travelaccounts, transcribed from the Swedish manuscripts and translated into English, narrating visits to Herculaneum, the Herculanense Museum and Pompeii, by Georg Fröman, Royal maçon, and Johan Tobias Sergel, sculptor, respectively. The texts are commented and put in historical context. Sergel's thorough accout of the Museum is read in parallel with th

Most chemistry, including chemistry where relativistic effects are important, occurs in an environment, and in many cases, this environment has a significant effect on the chemistry. In nonrelativistic quantum chemistry, a lot of progress has been achieved with respect to including environments such as a solvent or protein in the calculations, and now is the time to extend the possibilities for al

The distributions of transverse momentum and longitudinal momentum fraction of charged particles in jets are measured in Pb+Pb and pp collisions with the ATLAS detector at the LHC. The distributions are measured as a function of jet transverse momentum and rapidity. The analysis utilises an integrated luminosity of 0.14 nb- 1 of Pb+Pb data and 4.0 pb- 1 of pp data collected in 2011 and 2013, respe

Recent studies of THAP1 (DYT6) have pointed out that late-onset focal dystonia can have a genetic basis. Familial late-onset primary dystonia has not been described in African- Americans. Six members of an African American family were affected by focal or segmental dystonia with a mean age at onset of 47 years (range, 45-50). Two additional individuals with milder clinical signs were classified as

In recent years, much attention has been focused on the hydrogenolysis of biodiesel derived glycerol to other high value products for the sustainable development and efficient valorization strategies. In the present work, alumina-supported Ir catalyst was prepared by the incipient wetness impregnation method and tested in the glycerol hydrogenolysis reaction. The synthesized catalyst was character

Pervaporation is a membrane separation process with considerable innovative possibilities in the area of biotechnology. Above all, the combination of bioreactor and pervaporation has potential in the longer term as an alternative to conventional batch processes. This article considers the state of the art of pervaporation/bioreactor hybrid processes. The possible applications of such hybrid proces

There are many different frequency bands above 6 GHz and into the mm-wave range above 30 GHz that are possible candidates for use in future 5G cellular systems. In this paper, we present some results for wireless channels at 15 and 28 GHz in an indoor scenario. The results are based on both measurements and ray tracing simulations. Basic comparisons of measured and simulated power-delay profiles,

A measurement of the inclusive pp→tt+X production cross section in the τ+jets final state using only the hadronic decays of the τ lepton is presented. The measurement is performed using 20.2 fb-1 of proton-proton collision data recorded at a center-of-mass energy of s=8 TeV with the ATLAS detector at the Large Hadron Collider. The cross section is measured via a counting experiment by imposing a s

The production of two prompt J/ ψ mesons, each with transverse momenta pT> 8.5 GeV and rapidity |y| < 2.1 , is studied using a sample of proton-proton collisions at s=8 TeV, corresponding to an integrated luminosity of 11.4 fb- 1 collected in 2012 with the ATLAS detector at the LHC. The differential cross-section, assuming unpolarised J/ ψ production, is measured as a function of the transverse mo

An increasing number of older people in the population will bring new challenges for the society and care coordination. One of the most important questions in care coordination is the employees’ work performance. The overall aim of this study was to examine care employees’ experience of factors that rule how they allocate their time and tasks in the care work. The study was qualitative and consist