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Post-mortem analysis of brains from Parkinson's disease (PD) patients strongly supports microglia activation and adaptive immunity as factors contributing to disease progression. Such responses may be triggered by alpha-synuclein (alpha-syn), which is known to be the main constituent of the aggregated proteins found in Lewy bodies in the brains of PD patients. To investigate this we used a recombi

The sensitivity of agricultural crops to climate change is a major area for climate impact studies. The relationship between climate and three key phenolic compounds in grape skins important to premium wine quality (anthocyanins, tannins, and total phenolics) has not been well-studied. Here we conducted a three-year field study to collect and analyze berry samples from Pinot noir vineyards in the

Background and Objective: Total tumor resection in patients with glioblastoma multiforme (GBM) is difficult to achieve due to the tumor's infiltrative way of growing and morphological similarity to the surrounding functioning brain tissue. The diagnosis is usually subjectively performed using a surgical microscope. The objective of this study was to develop and evaluate a hand-held optical touch p

Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. Previous work showed that glucose activates the transcription factor Nuclear Factor of Activated T cells (NFAT) in arteries ex vivo. NF

Myeloid leukemia of Down syndrome has a better prognosis than sporadic pediatric acute myeloid leukemia. Most cases of myeloid leukemia of Down syndrome are characterized by additional cytogenetic changes besides the constitutional trisomy 21, but their potential prognostic impact is not known. We, therefore, conducted an international retrospective study of clinical characteristics, cytogenetics,

In this article, I will apply parts of the method introduced by Linda Hutcheon in her recently reedited book A Theory of Adaptation (2010) and try to answer the question “why” an adaptation is made. I will particularly study three complex cases of adaptation, which might even put into question the definition of adaptation itself, but I will concentrate on aspects related to immersion and self-refe

Folkhögskola 2.0 är ett kompetensutvecklingsprojekt i Skåne inom ramen för Europeiska socialfondens programområde 1. Projektet är på många sätt ett omfattande projekt. Det har ett brett, övergripande syfte som spänner över flera områden. I projektet är aktörer från flera folkhögskolor inblandade i ledningsarbetet och det berör ett stort antal medarbetare från olika yrkeskategorier. Projektet har p

Objectives - To investigate whether there is a relationship between the clinical occurrence of migraine and biliary tract disorders (BTD) and to study whether there is a genetic influence on such an association. Materials and Methods - The near lifetime morbidity for migraine and BTD was examined in two Swedish twin-samples: OCTO-Twin (149 MZ and 202 DZ pairs; 234 men, 468 women; 80 years of age o

Background: Older persons' right to exercise self-determination in daily life is supported by several laws. Research shows that older persons' self-determination is not fully respected within the healthcare sector. In order to enable and enhance older persons' self-determination, extensive knowledge of older persons' self-determination is needed. The aim of this study was to explore experiences of

Current nitrogen (N) deposition rates are considerably higher than during pre- industrial times and the growing interest in forest fertilisation requires better understanding of how the N and carbon (C) cycles interact. This study is based on experimental data showing how Scots pine (Pinus sylvestris L.) forests respond to single or consecutive pulse doses of N. The data were used to support the i

Investigation of optimized spatial precision for surface temperature measurements is performed. The temperature is measured by means of two-color ratio imaging with ICCD cameras, using the thermographic phosphor BAM. The precision in temperature is put in relation to the spatial resolution, two quantities which involve a trade-off in this case: the more spatial smoothing the better precision, but

Background: Distal radius fracture is a common injury and may result in substantial dysfunction and pain. The purpose was to investigate the relationship between distal radius fracture malunion and arm-related disability. Methods: The prospective population-based cohort study included 143 consecutive patients above 18 years with an acute distal radius fracture treated with closed reduction and eit

The mystacocarid crustacean Derocheilocaris typica has two microvillar organs, one new, the other previously unappreciated in crustacean literature. The first is situated on the head-shield and consists of three pairs of cells: one with microvilli and a ballooned nucleus; one smaller and without special features; the third large and investing the other two and extending down to the foregut. We cal

Popular Abstract in Swedish De ökande kraven på högre datahastigheter inom trådlös kommunikation ställer allt högre krav på både radiosändare och mottagare, då dessa behöver utnyttja fler frekvensband med större bandbredd vid högre frekvenser. Fokus i denna avhandling ligger på högfrekvensdelen av radiomottagaren, som består av lågbrusförstärkare, blandare, och oscillatorer vid mikrovågsfrekvenserThe increasing demand for high data rates in wireless communication systems is increasing the requirements on the transceiver front-ends, as they are pushed to utilize more and wider bands at higher frequencies. The work in this thesis is focused on receiver front-ends composed of Low Noise Amplifiers (LNAs), Mixers, and Voltage Controlled Oscillators (VCOs) operating at microwave frequencies. Tra

Forests are generally considered to be net sinks of atmospheric methane (CH4) because of oxidation by methanotrophic bacteria in well-aerated forests soils. However, emissions from wet forest soils, and sometimes canopy fluxes, are often neglected when quantifying the CH4 budget of a forest. We used a modified Bowen ratio method and combined eddy covariance and gradient methods to estimate net CH4