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Background: A pilot study investigating proteomic profiles from 78 patients from the Target Temperature Management after Out-of-hospital Cardiac arrest (TTM) trial revealed 35 proteins associated to functional outcome, and six proteins associated to targeted temperature management at 33 °C. We present the protocol for a study investigating proteomic profiles in the full cohort of the TTM-trial bio

We study the geometric significance of Leinster’s magnitude invariant. For closed manifolds we find a precise relation with Brylinski’s beta function and therefore with classical invariants of knots and submanifolds. In the special case of compact homogeneous spaces we obtain an elementary proof that the residues of the beta function contain the same geometric information as the asymptotic expansi

Let G be a group. Then S⊆G is an invariable generating set of G if every subset S′ obtained from S by replacing each element with a conjugate is also a generating set of G. We investigate invariable generation among key examples of branch groups. In particular, we prove that all generating sets of the torsion Grigorchuk groups, of the branch Grigorchuk-Gupta-Sidki groups and of the torsion multi-E

Background: The mitral valve is essential for proper heart function. Patient-specific simulations may provide insights into valve function and provide hemodynamic information for treatment planning. This study presents a framework for patient-specific mitral valve hemodynamic prediction and the validation of the simulation model against echocardiographic and MRI data. Methods: Ten healthy voluntee

Nitrogen removal from wastewater with anammox saves energy and resources. Partial denitrification-anammox (PDA) is a promising process alternative for municipal wastewater treatment, given that the understanding about how to control the microbiome and its activity reach sufficient level. Here, two moving bed biofilm reactors were fed with either acetate or propionate to study the role of organic c

This article develops an argument that in hybrid regimes, different levels of party competition incentivize incumbents to subvert the police in distinct ways, resulting in more corrupt or more repressive policing practices. In competing-pyramid hybrid regimes, such as Ukraine (2013–2019), elites have stronger incentives to preserve police corruption as a tool for immediate resource extraction amid

The formation of platoons, where groups of vehicles follow each other at close distances, has the potential to increase road capacity. In this paper, a decentralized control approach is presented that extends the well-known constant headway vehicle following approach to the two-dimensional case, i.e., lateral control is included in addition to the longitudinal control. The presented control scheme

Segmental gain of chromosome 17q is the most common genetic aberration in high-risk neuroblastoma, but its role in disease progression is poorly understood. This study aims to address the contribution of 17q gain to neuroblastoma malignancy. We analyzed the genetic and transcriptional landscape of 417 neuroblastoma patients across various risk groups and clinical stages using multi-omic approaches

OBJECTIVES: To investigate hip dysplasia as a risk factor for clinically relevant and incident radiographic hip OA.METHODS: From a prospective cohort (CHECK) of 1002 middle-aged, new consulters for hip and/or knee pain, 468 hips (251 individuals) were selected based on hip pain, available lateral center edge angle (LCEA) and absence of definite radiographic hip OA (Kellgren and Lawrence [KL] grade

The relationship between degree of coronary artery stenosis and its effect on myocardial perfusion is complex and constitutes a clinical challenge. The aim of this study was to assess diagnostic accuracy of visual assessment of invasive coronary angiography (ICA) for detecting reduced myocardial perfusion determined by quantitative first-pass perfusion (qFPP) cardiac magnetic resonance (CMR) in pa

In this work we investigate the development of functionally graded cemented carbides, featuring macro gradients on the millimeter scale, where Fe, or Ni is the binder phase. Two composites, WC-Ni and WC-Fe with 20 % binder by volume were produced by addition of TiC on the surface of the samples before sintering at 1475 °C for 1 h. The sintered samples were analyzed using electron microscopy and mi

Many women are occupationally active during pregnancy. The aim of this study was to investigate associations between exposure to chemicals during pregnancy and the risk of gestational diabetes or preeclampsia. The cohort included singleton births in Sweden between 1994 and 2014. The cohort was limited to low-educated mothers to reduce potential confounding from unidentified life-style associated f

Despite the importance of mineral-associated organic matter (MAOM) in long-term soil carbon (C) and nitrogen (N) persistence, and the significant contribution of fungal necromass to this pool, the factors controlling the formation of fungal-derived MAOM remain unclear. This study investigated how fungal necromass chemistry, specifically melanin, interacts with soil mineral properties and microbial

In this paper, we present a framework to identify discrete-time, single-input/single-output, switched linear systems (SISO-SLSs) from input–output data measurements. Continuous state is not assumed to be measured. The key step is a deadbeat observer-based transformation of the SLS model to a switched auto-regressive with exogenous input (SARX) model. Discrete states are estimated by a three-stage

Climate anxiety is gaining increasing attention but how it is related to both impairment and climate change activism through the use of emotion-focused coping strategies is still poorly understood. We conducted two studies to help understand psychological predictors for climate anxiety-related impairment (Study 1) and gain insights into the roles of trait mindfulness and emotion regulation for dif

Soil erosion is a critical process influencing the global carbon cycle. However, erosion-induced carbon changes remain inadequately understood, particularly for soil inorganic carbon (SIC). There is also limited knowledge about the factors influencing soil carbon dynamics during erosion processes. Here we quantify the global translocation of soil organic carbon (SOC) and SIC due to soil erosion us

Quantifying the spatial and temporal patterns of drought characteristics is crucial, given the increasing frequency and intensity of drought events over the past 20 years in China. However, the patterns of drought frequency and duration in different regions and their differences remain unclear. Traditional indices for detecting and quantifying droughts, such as the Standardized Precipitation Evapo

The power extracted by reverse electrodialysis (RED) is often limited by the high resistance of low concentration compartment. This work aims to address this issue by demonstrating a reverse electrodeionization (REDI) design that can facilitate the ion transport and alleviate so called spacer shadow effects. In total, three different stack designs were assembled by substituting the conventional sp

An adaptive controller is proposed and analyzed for the class of infinite-horizon optimal control problems in positive linear systems presented in (Ohlin et al., 2024b). This controller is derived from the solution of a “data-driven algebraic equation” constructed using the model-free Bellman equation from Q-learning. The equation is driven by data correlation matrices that do not scale with the n

This paper presents a novel adaptive autotuning strategy for controlling the pH in microalgae raceway reactors, a critical variable in optimizing biomass productivity under dynamic environmental conditions. The method expands on existing relay-based autotuning principles, tailored to suit the seasonally variable dynamics of microalgae cultivation systems influenced by CO2 injection and photosynthe