Typing of amyloidosis by mass spectrometry (MS) based proteomic analysis contribute to the diagnosis of amyloidosis. For MS analysis, laser microdissection (LMD) is used for amyloid specific sampling. This study aimed to establish a method for selectively extracting amyloids from formalin-fixed, paraffin-embedded (FFPE) specimens by organic solvent instead of LMD. The extracts using dimethyl sulfo

Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer’s disease (AD), where the ApoE4 variant is the highest genetic risk factor for this disease. ApoE is commonly found in amyloid deposits of different origins, and its interaction with amyloid-β peptide (Aβ), the hallmark of AD, is well known. However, studies on the interaction of A

Purpose: Disability affects upwards of one billion people worldwide, the majority of whom live in low- and middle-income countries. Based on survey data from Bangladesh, the aim of the study is to contribute to an improved understanding of the experiences of people with disabilities in terms of discrimination, health, and sociodemographic indicators. Method: A descriptive analysis of data is prese

In this paper, we discuss the exclusive photoproduction of ground and excited states of ψ(1S,2S) and ϒ(1S,2S) in ultraperipheral collisions (UPCs). Using the potential model in order to obtain the vector meson wave function, we find a good agreement of our calculations with data from the LHC and HERA colliders for J/ψ(1S,2S) and ϒ(1S) in γp collisions. We extend the calculations to the nuclear tar

Background and aims: Dipeptidyl peptidase 4 (DPP-4) inhibitors have anti-inflammatory and atheroprotective effects. We evaluated the effects of the DPP-4 inhibitor linagliptin on atherosclerotic plaque and hepatic inflammation using histology and 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG), a positron emission tomography tracer of inflammation, in a mouse model of hypercholesterolemia and type 2 di

Research on ontological security in world politics has mushroomed since the early 2000s but seems to have reached an impasse. Ontological security is a conceptual lens for understanding subjectivity that focuses on the management of anxiety in self-constitution. Building especially on Giddens, IR scholars have emphasized how this translates to a need for cognitive consistency and biographical cont

Aim: The aim of this observational study was to investigate relationships between physiological levels of glucometabolic biomarkers and cognitive test results in a population-based setting. Methods: Cross-sectional data were obtained from the Swedish population-based Malmö Diet and Cancer Study Re-examination 2007–2012 comprising 3001 older people (mean age 72 years). Through oral glucose toleranc

Wealth is highly correlated between parents and their children; however, little is known about the extent to which these relationships are genetic or determined by environmental factors. We use administrative data on the net wealth of a large sample of Swedish adoptees merged with similar information for their biological and adoptive parents. Comparing the relationship between the wealth of adopte

This paper is intended to introduce the technology to solve some of the deficiencies of the direct digital radiology. Nowadays, digital radiology is the latest progression in dental imaging, which has become an essential part of dentistry. There are two main parts of the direct digital radiology comprised of an intraoral X-ray machine and a sensor (digital image receptor). The dentists and the den

The misfolding and aberrant aggregation of proteins into fibrillar structures is a key factor in some of the most prevalent human diseases, including diabetes and dementia. Low molecular weight oligomers are thought to be a central factor in the pathology of these diseases, as well as critical intermediates in the fibril formation process, and as such have received much recent attention. Moreover,

This study illuminates how 25 in-patients who were treated for anorexia nervosa in a highly specialized clinic for eating disturbances in Sweden experienced the treatment program. The program included structured eating, medication, restrictions in physical activity and supportive dialogues. Patients were also offered semi-standardized NADA ear acupuncture as a complement to relieve stress, anxiety

Purpose: To examine the feasibility of automatic data extraction from clinical radiation therapy (RT) databases at four hospitals to investigate the impact of mean lung dose (MLD) and age on the risk of early respiratory-related death and early overall death for patients treated with RT for non-small-cell lung cancer (NSCLC). Material and methods: We included adult patients with NSCLC receiving cu

The Neptunian satellite system is unusual, comprising Triton, a large (∼2700 km) moon on a close-in, circular, yet retrograde orbit, flanked by Nereid, the largest irregular satellite (∼300 km) on a highly eccentric orbit. Capture origins have been previously suggested for both moons. Here we explore an alternative in situ formation model where the two satellites accreted in the circum-Neptunian d

Introduction: Targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) has been recommended in international guidelines since 2005. The TTM-trial published in 2013 showed no difference in survival or neurological outcome for patients randomised to 33 °C or 36 °C, and many hospitals have changed practice. The optimal utilization of TTM is still debated. This study aimed to

High biogenic silica (BSi) concentration occurs sporadically in lake sediments throughout the world, however, the processes leading to high BSi concentrations varies. While BSi formation and preservation is expected to occur in silica-rich environments with high dissolved silicon (DSi) concentrations such as volcanic and hydrothermal inputs, the factors and mechanisms explaining high DSi and BSi c

Sunlight consists of beams of light of broad wavelength ranges, including infrared, visible, and ultraviolet (UV) radiation; X-rays; and γ-rays. Although the UV content of sunlight is relatively low, the human body, especially the human skin, is sensitive to UV rays. Mica is known to be effective in protecting the human skin from sunlight and reduces fine lines and pores on the skin. Mica is curre

Cloud computing, owing to its ubiquitousness, scalability and on-demand ac- cess, has transformed into many traditional sectors, such as telecommunication and manufacturing production. As the Fifth Generation Wireless Specifica- tions (5G) emerges, the demand on ubiquitous and re-configurable computing resources for handling tremendous traffic from omnipresent mobile devices has been put forward.