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AIM: To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.MATERIALS & METHODS: Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged
Deep neural network architectures have recently produced excellent results in a variety of areas in artificial intelligence and visual recognition, well surpassing traditional shallow architectures trained using hand-designed features. The power of deep networks stems both from their ability to perform local computations followed by pointwise non-linearities over increasingly larger receptive fiel
Secretory leukocyte protease inhibitor (SLPI) is a well-known protease inhibitor. Its function is thought to be protease/protease-inhibitor balance. Free proteolytic activity, mainly pancreatic elastase, anionic trypsin and granulocytic elastase, has been demonstrated in faecal extracts from patients with ulcerative colitis. We wanted to verify that SLPI is actually secreted from normal human colo
Disasters and climate change impacts, as well as increased water demand, pose serious risks to the provision of sustainable urban water services, e.g., drinking water, sanitation, and safe drainage, especially in cities. These challenges call for a transition toward improved water management, including considerations of “resilience.” However, because the resilience concept has multidisciplinary or
Background: The aim of this paper was to investigate the role of SLPI in patients with allergic rhinitis. From this point of view, we also examined leukocyte elastase, α1-antitrypsin, and albumin. SLPI is an inhibitor of serine proteases such as leukocyte elastase, cathepsin G, and mast-cell chymase. Since chymase is considered to participate in mast-cell degranulation and histamine release, SLPI
This paper explores the current role of mindfulness in sustainability science, practice, and teaching. Based on a qualitative literature review that is complemented by an experimental learning lab, we sketch the patterns and core conceptual trajectories of the mindfulness–sustainability relationship. In addition, we assess this relationship within the field of climate change adaptation and risk re
Ten ileal T-cannulated pigs (19.26 ± 1.06 kg) were used to evaluate the effects of a novel Buttiauxella phytase on apparent ileal digestibility (AID) of AA and apparent total tract digestibility (ATTD) and hindgut disappearance of DM, GE, CP, crude fiber, NDF, and ADF as well as minerals balance. Pigs were fed in a duplicated 5 × 4 incomplete Latin square design (5 diets with 4 periods). Each peri
China and India, two countries with skewed sex ratios in favor of males, have introduced a wide range of policies over the past few decades to prevent couples from deselecting daughters, including criminalizing sex-selective abortion through legal jurisdiction. This article aims to analyze how such policies are situated within the bio-politics of population control and how some of the outcomes ref
Delvenne et al. present theoretical considerations about the pedagogy of technology assessment (TA) in general and the summer school format in particular, which was chosen as a platform for teaching TA in the PACITA project. The PACITA summer school programme was designed to encourage the uptake and use of TA rationale and methods by various types of professionals involved in science, technology o
In the paper we introduce an optimization framework for traffic restoration in optical wireless networks. As such networks experience multiple partial link failures, we introduce a generic extension of restoration strategies developed for wired networks (that assume total link failures) which enables handling partial link failures as well. The particular traffic restoration strategy studied in the
The kinetics and mechanism for the overall reaction (i) (X = Cl or Br) have been studied at 25.0 °C using stopped-flow spectrophotometry. 3[AuX4]–+ 7SCN–+ 4H2O → 3[Au(SCN)2]–+ HSO4–+ HCN + 12X–+ 6H+ (i), The reaction takes place in two kinetically well separated steps. The initial, rapid process can be identified as stepwise ligand substitutions (ii) (n= 0–3) which take place via direct ligand disThe kinetics and mechanism for the overall reaction (i) (X = Cl or Br) have been studied at 25.0 °C using stopped-flow spectrophotometry. 3[AuX4]–+ 7SCN–+ 4H2O → 3[Au(SCN)2]–+ HSO4–+ HCN + 12X–+ 6H+ (i) The reaction takes place in two kinetically well separated steps. The initial, rapid process can be identified as stepwise ligand substitutions (ii) (n= 0–3) which take place via direct ligand disp
BACKGROUND: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.METHODS: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between
Review of Avner Offer & Gabriel Söderberg, The Nobel Factor
Recently interest has been focused on secretory leucocyte protease inhibitor (SLPI) and its role in immediate hypersensitive reactions, possibly by inhibiting mast cell chymase. The purpose of this investigation was to show whether or not SLPI is produced in mast cells. Double-immunolabelling revealed that SLPI coexists with mast cell tryptase (60%) and chymase (37%). On the other hand, in situ hy
The kinetics for the reactions between the complexes PtCln(H2O)4-n 2−n, n = 0,1,2,3,4, (including cis- and trans-isomers for n=2) and ethene have been studied. In the case of trans-PtCl2(H2O)2, product analysis shows that both the chloride ligand and the aqua ligand are substituted by ethene in two parallel paths, differing in rate by a factor of only 1.5. The experiments show that ethene, and proThe kinetics for the reactions between the complexes PtCln(H2O)4-n 2−n, n = 0,1,2,3,4, (including cis- and trans-isomers for n = 2) and ethene have been studied. In the case of trans-PtCl2(H2O)2, product analysis shows that both the chloride ligand and the aqua ligand are substituted by ethene in two parallel paths, differing in rate by a factor of 1.5 only. The experiments show that ethene, and p
