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Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants

Background: Lentiviral vectors hold great promise as gene transfer vectors in gene therapeutic settings. However, problems related to the risk of insertional mutagenesis, transgene silencing and positional effects have stalled the use of such vectors in the clinic. Chromatin insulators are boundary elements that can prevent enhancer-promoter interactions, if placed between these elements, and prot

The Gaia inertial reference frame and the tilting of the Milky Way disk

While the precise relationship between the Milky Way disk and the symmetry planes of the dark matter halo remains somewhat uncertain, a time-varying disk orientation with respect to an inertial reference frame seems probable. Hierarchical structure formation models predict that the dark matter halo is triaxial and tumbles with a characteristic rate of similar to 2 rad H-0(-1) (similar to 30 mu as

Laminar burning velocities of n-heptane, iso-octane, ethanol and their binary and tertiary mixtures

Measurements of the adiabatic laminar burning velocities of n-heptane, iso-octane, ethanol and their binary and tertiary mixtures are reported. Non-stretched flames were stabilized on a perforated plate burner at 1 atm. The Heat Flux method was used to determine burning velocities under conditions when the net heat loss from the flame to the burner is zero. Initial temperatures of the gas mixtures

Syntaktisk variation och förändring : En studie av subjektslösa satser i fornsvenska

The topic of this thesis is subjectless clauses in Old Swedish (1225–1526). The thesis focuses on referential subjects, and addresses the problem of why the possibilities to leave out such subjects have been reduced during the history of Swedish. The dissertation consists of three main parts, divided into eight chapters. In the first part, chapters 1–3, the aims are presented and a theoretical bac

Heavy Ion Inital States from DIPSY

A BFKL dipole model, and its event generator DIPSY, developed for pp collisions is extended to initial states of heavy ion collisions. All tuning is made for gamma*p and pp inclusive and minimum bias data, leaving the extension to heavy ions model independent. Eccentricities are calculated and compared to other common inital state models.

The Ferrum project: experimental and theoretical transition rates of forbidden [Sc II] lines and radiative lifetimes of metastable Sc II levels

Context. In many plasmas, long-lived metastable atomic levels are depopulated by collisions (quenched) before they decay radiatively. In low-density regions, however, the low collision rate may allow depopulation by electric dipole (E1) forbidden radiative transitions, so-called forbidden lines (mainly M1 and E2 transitions). If the atomic transition data are known, these lines are indicators of p

Kategoriseringar av barn i förskoleåldern : Styrning & administrativa processer

The present thesis investigates, analyses and critically discusses the manner in which children with special needs are categorised in the Swedish preschool. The emergence of the category and its construction depends on a number of “truths” concerning children, related to historical and cultural processes in society. A main focus of the thesis is to investigate how legitimacy is established for the

Search for a Standard Model Higgs boson in the mass range 200-600 GeV in the H -> ZZ -> l(+)l(-)q(q)over-bar decay channel with the ATLAS detector

A search for a heavy Standard Model Higgs boson decaying via H -> ZZ -> l(+)l(-)q (q) over bar, where l = e or mu, is presented. The search uses a data set of pp collisions at root s = 7 TeV, corresponding to an integrated luminosity of 4.7 fb(-1) collected in 2011 by the ATLAS detector at the CERN LHC. No significant excess of events above the estimated background is found. Upper limits at 95% co

A Common Prostate Cancer Risk Variant 5 ' of Microseminoprotein-beta (MSMB) Is a Strong Predictor of Circulating beta-Microseminoprotein (MSP) Levels in Multiple Populations

Background: beta-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. Methods: We examined the association between rs10993994 genotype and MSP l

Volatility Risk Premium, Risk Aversion and the Cross-Section of Stock Returns

We test if innovations in investor risk aversion are a priced factor in the stock market. Time series tests show that the new factor partly explains the strong momentum effect in stock returns. Furthermore, using 25 portfolios sorted on book-to-market and size as test assets, our new factor together with the market factor explains 64% of the variation in average returns compared to 60% for the Fam

Chemical Management Services from a Product Service System perspective: Experiences of fluid management services from Volvo Group metalworking plants

This thesis analyses fluid management services (FMS) in metalworking industry and determines environmental and economic outcomes of FMS as compared to traditional, in-house, fluid management. Fluid management services, or as it is often called chemical management services (CMS), mean that the suppliers of chemicals are also involved in managing and maintaining the fluids in the use phase. Usually

Ab initio study of the downfolded self-energy for correlated systems: Momentum dependence and effects of dynamical screening

The electronic structure of strongly correlated systems is usually calculated by using an effective model Hamiltonian with a small number of states and an effective on-site interaction. The mode, however, neglects the frequency dependence of the interaction, which emerges as a result of dynamical screening processes not included in the model. The self-energy calculated in this kind of model within

Using network pictures to study inter-organisational encounters

This paper describes and illustrates how a network picture methodology can create understandings of external parties in mergers and acquisitions (M&As). Recent studies have brought attention to the limited use of qualitative research methods and the overlooked marketing perspective in M&A studies. Network pictures refer to how individual actors in companies perceive their company's busines

Taking the environment online : issue and link networks surrounding personal green living blogs

Purpose: This article explores the construction and configuration of environmentally friendly living through making visible the link networks that surround personal greener living blogs.The following questions guide the exploration: Which types of organisations/actors structure the issue network of green living blogs as it emerges through links? How do these links contribute to carving out themati